Anatomical study of the course of the inferior alveolar nerve in craniofacial microsomia using three-dimensional computed tomography: correlation with the Pruzansky classification

Neiva, Cecilie; Dakpe, Stéphanie; Davrou, Julien; Diner, P.A.; Devauchelle, Bernard; Vazquez, M.-P.; Picard, A.; Kadlub, Natacha

doi:10.1016/j.bjoms.2015.02.006

Cited by 6 publications

(7 citation statements)

References 16 publications

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“…2 Additionally, in congenital anomalies like CFM, the IA canal is completely absent on the severely affected side of the mandible and not so on the unaffected side. 3 These observations suggest that the IA nerve may play a role in prenatal mandibular development and probably influence the shape of the mandible. However, there is currently no published literature that evaluates the possible morphological integration of the IA canal shape and the mandibular shape.…”

Section: Discussionmentioning

confidence: 89%

“…It has been observed that during mandibular embryogenesis, the centre of mandibular ossification starts around the IA nerve bifurcation 2 . Additionally, in congenital anomalies like CFM, the IA canal is completely absent on the severely affected side of the mandible and not so on the unaffected side 3 . These observations suggest that the IA nerve may play a role in prenatal mandibular development and probably influence the shape of the mandible.…”

Section: Discussionmentioning

confidence: 98%

“…During embryogenesis of mandible, the first site of ossification occurs at the bifurcation of the IA and the mental nerves 2 . Furthermore, in patients with severe craniofacial microsomia (CFM) – particularly in the Pruzansky type III – it has been shown that the IA canal (mandibular canal) was completely absent on the microsomic side 3 . These observations, taken together, suggest that the IA nerve could play a role in driving mandibular embryogenesis and establishing early mandibular shape.…”

Section: Introductionmentioning

confidence: 99%

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Morphological integration in inferior alveolar canal and mandibular shapes

Alhazmi,

Nicholas,

Vora

et al. 2023

Orthod Craniofacial Res

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ObjectiveDuring embryogenesis of mandible, the initial ossification centre begins at the bifurcation of the inferior alveolar (IA) and the mental nerves. Additionally, in congenital anomalies like craniofacial microsomia (CFM), the IA canal is completely absent on the microsomic side. These observations led us to hypothesise that there may be a morphological integration between these structures – the IA nerve and the mandibular shapes. Therefore, the primary objective of this study was to test for morphological integration between these structures and the secondary objective was to determine if there were shape variations in these structures among skeletal Classes I, II and III subjects.Setting and sample populationThe sample size of the study is 80 full‐head cone‐beam computed tomography (CBCT) scans (age 16–56 years).MethodsWe retrieved CBCT scans from our archived database using specific inclusion/exclusion criteria. In the de‐identified CBCT scans, traditional coordinate landmarks and sliding semi‐landmarks were placed on the mandible and the IA canal (proxy for IA nerve). Using geometric morphometric analyses, we tested integration between the IA canal and the mandibular shapes. We used Procrustes ANOVA to test for overall shape variations among the three skeletal classes (Classes I, II and III).ResultsThe IA canal and posterior/inferior border of mandible showed strong integration (r‐PLS = .845, P = .001). Similar strong integration was also observed between the IA canal and the overall shape of the mandible (r‐PLS = .866, P = .001). Additionally, there was a statistically significant variation in overall shape between skeletal Class I and Class II (P = .008) and Class II and Class III (P = .001).ConclusionsThe strong integration between two structures suggests that the IA nerve may play a role in establishing mandibular shape early in development. We posit this may be important in driving mandibular defects seen in CFM, which warrants further investigation.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Morphological integration in inferior alveolar canal and mandibular shapes

Alhazmi,

Nicholas,

Vora

et al. 2023

Orthod Craniofacial Res

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“…The discrepancies in sample size and the proportion of the patient types could be the possible reason for this. Besides, several studies used Pruzansky classification only 14 , 15 , but Kaban modification helps classify patients precisely according to the morphology of the ramus and the condyle, we switched to the Pruzansky–Kaban classification to further find the differences of the course were mainly in type IIb, while there was no difference in IIa, which was significant for clinical decision.…”

Section: Discussionmentioning

confidence: 99%

Morphological and quantitative study of the inferior alveolar nerve canal in hemifacial microsomia

Li,

Chen,

Zhang

et al. 2024

Sci Rep

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This study aimed to probe into the anatomic course of inferior alveolar nerve canal (IANC) in hemifacial microsomia (HFM) on a large scale, morphological observations and further quantitative study were performed. Patients were classified by Pruzansky–Kaban classification. The anatomic course of IANC was analyzed morphologically with three-dimensional (3D) imaging software among 248 patients. Seven distances between fixed landmarks on both sides were measured for 236 patients. The differences between affected and unaffected sides were compared. Significant differences were found in the entrance (P < 0.001), route (P < 0.001), and exit (P < 0.05) of IANC in type IIb and III HFM. The higher the degree of mandibular deformity was, the higher the incidence of IANC variation was (P < 0.05). The distances in the horizontal aspect of IANC including from mandibular foramen to mental foramen (P < 0.05) and from mental foramen to gonion (P < 0.05) were significantly shorter on the affected side. Abnormalities of the anatomical course of IANC exist in patients with Pruzansky–Kaban type IIb and type III HFM. The reduction of IANC on the affected side in the horizontal distance is more obvious. Three-dimensional imaging assessment is recommended before surgery.

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“…The mandibular body unit is intimately related to the development of the inferior alveolar neurovascular bundle during the developmental period. Neiva et al measured the length of inferior alveolar canal with 3D CT for hemifacial microsomia [ 28 ]. And they found no significant difference of the bony canal length between the affected and non-affected side of Pruzansky’s type I group subjects, while those of Pruzansky’s type II to be significantly different.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional functional unit analysis of hemifacial microsomia mandible—a preliminary report

Choi

Kim

et al. 2015

Maxillofac Plast Reconstr Surg

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BackgroundThe aim of this study was to present three-dimensional (3D) structural characteristics of the mandible in the hemifacial microsomia. The mandible has six distinct functional units, and its architecture is the sum of balanced growth of each functional unit and surrounding matrix.MethodsIn order to characterize the mandibular 3D architecture of hemifacial microsomia, we analyzed the mandibular functional units of four hemifacial microsomia patients using the 3D reconstructed computed tomography (CT) images. And we compared the functional unit size between affected and non-affected side.ResultsThe length of condyle and angle showed significant differences between affected and non-affected sides. However, the length of mandibular body showed insignificant differences. The size differences between affected and non-affected side were observed at the condyle, angle, and body in descending order.ConclusionsThis preliminary study suggests that the main etiopathogenic units are condyle and angle in the hemifacial microsomia mandible. Further investigation with the increased number of subjects will be helpful to establish treatment modality by etiopathogenic targeting of hemifacial microsomia.

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Anatomical study of the course of the inferior alveolar nerve in craniofacial microsomia using three-dimensional computed tomography: correlation with the Pruzansky classification

Cited by 6 publications

References 16 publications

Morphological integration in inferior alveolar canal and mandibular shapes

Morphological integration in inferior alveolar canal and mandibular shapes

Morphological and quantitative study of the inferior alveolar nerve canal in hemifacial microsomia

Three-dimensional functional unit analysis of hemifacial microsomia mandible—a preliminary report

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