Anaplastic Thyroid Carcinoma: Association With Differentiated Thyroid Cancer

Anaplastic (undifferentiated) thyroid carcinoma (ATC)

“…Anaplastic carcinomas might develop from papillary or follicular malignancies [7,16,42]. Contrary to Nishiyama et al [43], Hollinsky et al [38] and Schmid et al [16], we were not able to detect a better prognosis in patients with differentiated parts in their anaplastic tumors.…”

Aberrant L1 Cell Adhesion Molecule Affects Tumor Behavior and Chemosensitivity in Anaplastic Thyroid Carcinoma

“…In fact, previous studies reported transition zones from differentiated thyroid carcinoma to ATC in the same tumor tissue as well as tiny foci of differentiated thyroid carcinoma within ATCs (28,29). We also observed these transition zones in case 2, which exhibited moderate L1CAM expression in ATC areas compared with focal L1CAM expression in adjacent papillary structure (Supplementary Fig.…”

Frequency and degree of aneuploidy in benign and malignant thyroid neoplasms

“…It is generally accepted that undifferentiated thyroid carcinomas may arise from pre-existing well differentiated papillary and follicular carcinomas (Clark et al, 1966;Nishiyama et al, 1972;Harada et al, 1977;Spires et al, 1988). Our results indicate that progression towards undifferentiated carcinomas may be associated with a selection of highly aneuploid DNA stemlines.…”