Anaphylaxis to Intravenous Amiodarone

Fransi, S; Briedis, Juris

doi:10.1177/0310057x0403200418

Cited by 21 publications

(12 citation statements)

References 8 publications

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“…A few cases of hepatitis and one case report of anaphylaxis due to acute i.v. AD administration have been described (Agozzino et al 2002;Fransi and Briedis 2004;Bravo et al 2005). Also, in dogs, adverse effects due to chronic AD treatment include hepatopathy, anorexia, lethargy, pruritis, neutropenia and thrombocytopenia Gilbert et al 2000;Kraus et al 2005;Oyama and Prosek 2006).…”

Section: Discussionmentioning

confidence: 99%

Effects of an adapted intravenous amiodarone treatment protocol in horses with atrial fibrillation

Clercq

Loon

Baert

et al. 2007

Equine Veterinary Journal

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Section: Discussionmentioning

confidence: 99%

Effects of an adapted intravenous amiodarone treatment protocol in horses with atrial fibrillation

Clercq

Loon

Baert

et al. 2007

Equine Veterinary Journal

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“…Amiodarone is a broad-spectrum antiarrhythmic drug with unique side effects [6]. Anaphylactic shock associated with amiodarone is a rare condition [4,5]. It contains an iodine component which may be associated with anaphylactoid reactions [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Because of these side effects, generally it is not the drug of first choice in the treatment of arrhythmia and long-term usage of this drug is limited due to side effects [1]. Allergic reactions are reported with amiodarone treatment, but anaphylactic shock is a rare complication of this drug [2][3][4][5]. We hereby report a case of anaphylactic shock associated with intravenous amiodarone treatment.…”

Section: Introductionmentioning

confidence: 93%

Anaphylactic shock associated with intravenous amiodarone

Özcan

Zengin

Tatlısu

et al. 2014

Journal of Cardiology Cases

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A 64-year-old woman was admitted to our emergency department with shortness of breath and palpitation which started 2 h before her admission. She had a history of rheumatic mitral valve disease and was on drug treatment with warfarin and metoprolol. The patient was orthopneic, blood pressure was 108/68 mmHg with an irregular pulse with a heart rate of 158 beats per minute, and respiratory rate was 23 times per minute. Her electrocardiogram was consistent with atrial fibrillation with rapid ventricular response. For pharmacological cardioversion the patient was given amiodarone intravenous loading dose of 300 mg in 30 min. After 10 min of infusion the patient complained of pruritus and skin rash consistent with urticaria. At the same time the patient had dyspnea and bronchoconstriction was noted on both lung fields. The blood pressure was measured as 64/40 mmHg. The patient was taken to intensive care unit and supportive treatment for anaphylactic shock was given. Amiodarone is a class III antiarrhythmic agent frequently used in the management of atrial fibrillation. This potentially fatal complication of amiodarone should be kept in mind by clinicians and before administration patients should be questioned about previous allergic reactions including previous iodine or iodinated contrast media. Alternative agents should be considered in these conditions.

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“…Furthermore, there are only two cases in the literature describing anaphylactic reaction/shock attributed to amiodarone in humans, and their clinical course was quite different. 10,11 With these in mind, we did not proceed to further diagnostic tests for anaphylaxis (mast cells tryptase levels, skin testing).…”

Section: Case Studymentioning

confidence: 99%