Anaphylaxis to Intradermal Triamcinolone Acetonide

Context:Alopecia Areata (AA) is a common form of non-scarring hair disorder of unclear etiology. The disease may have serious psychological effect.Aims:The objective is to assess the therapeutic effect and side effects of various topical modalities for the treatment of AA.Settings and Design:Open, randomized, comparative study.Materials and Methods:For this study, 30 patients were included of all age groups and both sexes having localized (<5 patches and <25% scalp involvement) alopecia, with no underlying disease or family history, and who had not received any treatment before. They were treated sequentially with 5 different combination regimes for 3 months. The response was assessed subjectively as well as objectively by the “Severity of Alopecia Tool Score”.Statistical Analysis:Chi-square test.Results:Out of the 5 modalities studied, the Intralesional and Topical Steroids were the most effective with no significant side effects.Conclusions:Among the various topical modalities used for the treatment of AA, the most effective are the Intralesional and Topical steroids with no significant side-effects.

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“…[12] Adverse effects include pain, atrophy, headache, hyper/hypopigmentation, anaphylaxis,[13] and hemorrhage at the puncture site.…”

Section: Discussionmentioning

confidence: 99%

A Study to Evaluate the Efficacy of Various Topical Treatment Modalities for Alopecia Areata

2012

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“…Contact hypersensitivity to topical corticosteroids is rare but well recognized . Very rarely, intradermal injection of corticosteroids triggers an anaphylactic reaction …”

Section: Adverse Reactions To Drugs Used By Dermatologistsmentioning

confidence: 99%

Adverse drug reactions in dermatology

Ferner

2015

Clin Exp Dermatol

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Adverse drug reactions (ADRs) - that is, unintended and harmful responses to medicines - are important to dermatologists because many present with cutaneous signs and because dermatological treatments can cause serious ADRs. The detection of ADRs to new drugs is often delayed because they have a long latency or are rare or unexpected. This means that ADRs to newer agents emerge only slowly after marketing. ADRs are part of the differential diagnosis of unusual rashes. A good drug history that includes details of drug dose, time-course of the reaction and factors that may make the patient more susceptible, will help. For example, Stevens-Johnson syndrome with abacavir is much commoner in patients with HLA-B*5701, and has a characteristic time course. Newer agents have brought newer reactions; for example, acneiform rashes associated with epidermal growth factor receptor inhibitors such as erlotinib. Older systemic agents used to treat skin disease, including corticosteroids and methotrexate, cause important ADRs. The adverse effects of newer biological agents used in dermatology are becoming clearer; for example, hypersensitivity reactions or loss of efficacy from antibody formation and progressive multifocal leucoencephalopathy due to reactivation of latent JC (John Cunningham) virus infections during efalizumab treatment. Unusual or serious harm from medicines, including ADRs, medication errors and overdose, should be reported. The UK Yellow Card scheme is online, and patients can report their own ADRs.

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“…[16] There is a single case report of anaphylaxis in a patient receiving intralesional triamcinolone acetonide for treatment of Alopecia Areata. [17]…”

Section: Adverse Effectsmentioning

confidence: 99%

Intralesional steroids for alopecia areata

Kumaresan

2010

Int J Trichol

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Anaphylaxis to Intradermal Triamcinolone Acetonide

Cited by 31 publications

References 5 publications

A Study to Evaluate the Efficacy of Various Topical Treatment Modalities for Alopecia Areata

A Study to Evaluate the Efficacy of Various Topical Treatment Modalities for Alopecia Areata

Adverse drug reactions in dermatology

Intralesional steroids for alopecia areata

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