1969
DOI: 10.1001/archderm.1969.01610280068012
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Anaphylactic Shock Elicited by Topical Administration of Bacitracin

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Cited by 54 publications
(7 citation statements)
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“…In 35/48 patients (73%), various skin tests with incriminated substances were performed, which were reported to give positive reactions in all cases (at least one skin test was positive in cases where different skin tests were performed). Among the remaining 13/48 patients, one patient refused skin tests (3), and in one case (6), a Prausnitz‐Küstner test was performed which gave a positive result. No information on skin tests was provided for the remaining 11/48 cases (23%).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…In 35/48 patients (73%), various skin tests with incriminated substances were performed, which were reported to give positive reactions in all cases (at least one skin test was positive in cases where different skin tests were performed). Among the remaining 13/48 patients, one patient refused skin tests (3), and in one case (6), a Prausnitz‐Küstner test was performed which gave a positive result. No information on skin tests was provided for the remaining 11/48 cases (23%).…”
Section: Resultsmentioning
confidence: 99%
“…contact dermatitis, have also long been recognized as ADRs. However, drug induced anaphylaxis following topical drug application has been only rarely (1–7), and the occurrence of TEN or SJS associated with topical drug application has even less rarely been described (8–12). A systematic analysis of such cases is, thus, mainly hampered by the limited number of reports.…”
mentioning
confidence: 99%
“…Currently reported methods to test allergic reaction to bacitracin are passive transfer (Prausnitz-Kustner testing) in monkeys 5 and in a single human subject, 6 skin testing, and the levels of IgE against bacitracin using bacitracin and streptavidin ImmunoCAP testing (Phadia, Uppsalla, Sweden). 7 In 2008 Schroer et al 8 suggested that skin prick testing with an individual topical preparation was a useful and safe procedure to determine the cause of anaphylaxis in a patient who applied a topical neosporin preparation, thus confirming the findings of Saryan et al 9 However, in the present case, the integrity of the skin was lost owing to a traumatic injury, which allowed the absorption and entry of the drug into the systemic circulation.…”
Section: Anaphylaxis After Application Of Topical Bacitracin-neomycinmentioning
confidence: 99%
“…1 Although most reactions in children occur at home, harrowing accounts of fatalities in schools 3,4 highlight the need for advance preparation. Early studies found that a significant number of school-related anaphylactic reactions occur in individuals without a history of allergy 5,6 ; consequently, school districts across the country have begun to supply stock epinephrine. Stock epinephrine is a term used to refer to an unassigned supply of epinephrine that may be used to treat anyone experiencing a life-threatening reaction.…”
Section: Anaphylaxis After Application Of Topical Bacitracin-neomycinmentioning
confidence: 99%
“…D'autre part, Roupe et Stannegard [13] rapportent également le cas d'une fillette de 14 ans, ayant une dermatite atopique surinfectée, traitée par une pommade contenant de la Bacitracine, ayant présenté un choc anaphy lactique au moment même de l'application de la pommade.…”
Section: Réaction Cutanée Immédiateunclassified