Anaphylactic shock elicited by topical administration of bacitracin

Sensitization to tropical woods giving erythema multiforme‐like eruptions

“…A somewhat related complication concerns those cases of contact allergy with anaphylactic reactions observed in atopic patients. In one of these patients circulating antibodies directed against the eliciting agent were found (Roupe & Strannegaard 1969). We have not, however, seen any reports of erythema multiforme-like reactions connected with contact allergy to wood.…”

Erythema multiforme associated with contact dermatitis

“…A circulating antibody to the absorbed antigen could result in immune complex circulation and subsequent deposition in the microvasculature (8). Circulating antibodies to bacitracin were found in a patient who had anaphylaxis (type I reaction) elicited by topical administration of that antibiotic (12). Kazmierowski & Wuepper (13) and Finan & Schroeter (14) reported deposition of immunoglobulins and complement in the vessels of the papillary dermis in patients with erythema multiforme.…”

Contact urticaria provoked by balsam of Peru

“…It is well known that certain materials can precipitate urticaria. Examples are monoamylamine (Tharpe 1973), stearyl alcohol (Gaul 1969), potato (Pearson 1966), tetanus antitoxin (Sneddon 1960), 2hydroxy-4 methoxybenzophenone (Ebner 1974), sulphuric acid (Ramsay et al 1972), neomycin (Pippen 1966), penicillin (Maugher 1972, bacitracin (Roupe & Stamegari 1969), and mechlorethamine (Pippen 1966).…”

“…The phenomenon of contact urticaria is known (Calnan & Shuster 1963, Daughters et al 1973, Gaul 1969, Levene & Withers 1969, Maucher 1972, Mathews 1968, Pippen 1966, Roupe & Stamegari 1969, Sneddon 1960, Tharpe 1973. It is very rarely observed in clinical practice and fairly difficult to diagnose.…”