Anaphylactic Reaction to Lidocaine

Immunotherapy of lidocaine allergy by intravenous desensitization using IFN‐gamma from a case: Overcoming impediments using IFN‐gamma during desensitization

“…Unfortunately, there is no reliable in vitro allergy diagnostic test available for routine use . Type I hypersensitivity to lidocaine has been confirmed by demonstrating specific IgE antibodies against the drug and was reported in relatively few cases . In this report, the skin prick test was negative, but the intradermal test was strongly positive.…”

“…In the intravenous challenge test, although the patient exhibited suspected allergic responses at a lidocaine dose of 20 ng, the minimal allergy provocation dose was 30 ng, at which symptoms and signs appeared. The patient fell into anaphylaxis after the intravenous injection of 5 mg of lidocaine, and there have been reports of using the usual or full therapeutic dose of intravenous lidocaine . The precise minimal allergy provocation dose according to the intravenous provocation test was not described well, which may be because there was no established concept for desensitization at that time.…”

Immunotherapy of lidocaine allergy by intravenous desensitization using IFN‐gamma from a case: Overcoming impediments using IFN‐gamma during desensitization

“…Unfortunately, there is no reliable in vitro allergy diagnostic test available for routine use . Type I hypersensitivity to lidocaine has been confirmed by demonstrating specific IgE antibodies against the drug and was reported in relatively few cases . In this report, the skin prick test was negative, but the intradermal test was strongly positive.…”

“…In the intravenous challenge test, although the patient exhibited suspected allergic responses at a lidocaine dose of 20 ng, the minimal allergy provocation dose was 30 ng, at which symptoms and signs appeared. The patient fell into anaphylaxis after the intravenous injection of 5 mg of lidocaine, and there have been reports of using the usual or full therapeutic dose of intravenous lidocaine . The precise minimal allergy provocation dose according to the intravenous provocation test was not described well, which may be because there was no established concept for desensitization at that time.…”

Life‐threatening anaphylactic reaction after the administration of airway topical lidocaine

“…These symptoms usually develop within seconds or minutes after exposure to the inciting agent. Sometimes, however, the symptoms may not appear for several hours 11. The more rapid the onset of the anaphylaxis after exposure to an offending stimulus, as in our case (within 2 min), the more likely the reaction will be severe and life‐threatening 12…”

Delayed hypersensitivity reaction of the knee after injection of arthroscopy portals with bupivacaine (Marcaine)

“…Clinical features may include diffuse rash, nausea and vomiting, bronchospasm, hypotension, and even death. An anaphylactoid reaction is clinically indistinguishable from an anaphylactic reaction (8), except that no IgE-mediated response can be demonstrated.…”

Immunotherapy of lidocaine allergy by intravenous desensitization using IFN‐gamma from a case: Overcoming impediments using IFN‐gamma during desensitization

“…Unfortunately, there is no reliable in vitro allergy diagnostic test available for routine use . Type I hypersensitivity to lidocaine has been confirmed by demonstrating specific IgE antibodies against the drug and was reported in relatively few cases . In this report, the skin prick test was negative, but the intradermal test was strongly positive.…”

“…In the intravenous challenge test, although the patient exhibited suspected allergic responses at a lidocaine dose of 20 ng, the minimal allergy provocation dose was 30 ng, at which symptoms and signs appeared. The patient fell into anaphylaxis after the intravenous injection of 5 mg of lidocaine, and there have been reports of using the usual or full therapeutic dose of intravenous lidocaine . The precise minimal allergy provocation dose according to the intravenous provocation test was not described well, which may be because there was no established concept for desensitization at that time.…”

Life‐threatening anaphylactic reaction after the administration of airway topical lidocaine

“…These symptoms usually develop within seconds or minutes after exposure to the inciting agent. Sometimes, however, the symptoms may not appear for several hours 11. The more rapid the onset of the anaphylaxis after exposure to an offending stimulus, as in our case (within 2 min), the more likely the reaction will be severe and life‐threatening 12…”

Delayed hypersensitivity reaction of the knee after injection of arthroscopy portals with bupivacaine (Marcaine)

“…Clinical features may include diffuse rash, nausea and vomiting, bronchospasm, hypotension, and even death. An anaphylactoid reaction is clinically indistinguishable from an anaphylactic reaction (8), except that no IgE-mediated response can be demonstrated.…”

Immunotherapy of lidocaine allergy by intravenous desensitization using IFN‐gamma from a case: Overcoming impediments using IFN‐gamma during desensitization

“…Unfortunately, there is no reliable in vitro allergy diagnostic test available for routine use . Type I hypersensitivity to lidocaine has been confirmed by demonstrating specific IgE antibodies against the drug and was reported in relatively few cases . In this report, the skin prick test was negative, but the intradermal test was strongly positive.…”

“…In the intravenous challenge test, although the patient exhibited suspected allergic responses at a lidocaine dose of 20 ng, the minimal allergy provocation dose was 30 ng, at which symptoms and signs appeared. The patient fell into anaphylaxis after the intravenous injection of 5 mg of lidocaine, and there have been reports of using the usual or full therapeutic dose of intravenous lidocaine . The precise minimal allergy provocation dose according to the intravenous provocation test was not described well, which may be because there was no established concept for desensitization at that time.…”

Life‐threatening anaphylactic reaction after the administration of airway topical lidocaine

“…These symptoms usually develop within seconds or minutes after exposure to the inciting agent. Sometimes, however, the symptoms may not appear for several hours 11. The more rapid the onset of the anaphylaxis after exposure to an offending stimulus, as in our case (within 2 min), the more likely the reaction will be severe and life‐threatening 12…”

Delayed hypersensitivity reaction of the knee after injection of arthroscopy portals with bupivacaine (Marcaine)

“…Clinical features may include diffuse rash, nausea and vomiting, bronchospasm, hypotension, and even death. An anaphylactoid reaction is clinically indistinguishable from an anaphylactic reaction (8), except that no IgE-mediated response can be demonstrated.…”