Analyzing Neoadjuvant Chemotherapy Effects in HER2-Low Breast Cancer: Real World Data
Marcelo Antonini,
Andre Mattar,
Fernanda G Richter
et al.
Abstract:Purpose: Neoadjuvant chemotherapy (NAC) can be used as upfront therapy in aggressive breast cancer (BC). human epidermal growth factor receptor 2 (HER2)-low BC, defined as tumors scoring +1 or +2 on immunohistochemistry without HER2 gene amplification by in situ hybridization, lacks information on real-world data (RWD) outcomes, especially in the NAC setting. This subgroup, which does not reach the HER2 positive criteria due to its lower receptor expression, represents a distinct clinical category potentially … Show more
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