“…Recently, a rare nonsynonymous, presumed inactivating, mutation (p.Arg95Ter) in the gene encoding the orphan G-protein coupled receptor 151 (GPR151), a Gα o1 -linked GPCR, was associated with lower odds ratio for T2D, obesity and coronary artery disease 6 and with reduced body-mass index (BMI) [6][7][8] , although another recent study found no significant associations between putative loss-of-function (LOF) GPR151 variants and BMI, T2D, or other metabolic traits 9 .…”