1991
DOI: 10.1055/s-2007-1019994 View full text |Buy / Rent full text
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Abstract: The influence of calcium, resting force and temperature on the contractile behaviour in isolated demembranized ("skinned") pig papillary muscle fibers (n = 36) was analysed. Demembranisation excludes the influence of any membrane related processes on the contractile response as the myofilaments are in direct contact with the bathing medium. Resting force (1 mN-9 mN), temperature (22 degrees C or 32 degrees C) and pCa 7.0-4.3 were varied and the contractile response was analyzed by studying the time constant an… Show more

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“…Furthermore the described differences in the excitation-contraction coupling still remain intact in nonpermeabilized preparations. And additionally the calcium sensitivity is species dependent [ 21 - 24 ]. A potential correlation of sex, cardiac disease and disease progression obviously exists, but it is still not known how sex influences the signaling pathways, which impacts the contractile properties [ 2 ].…”
Section: Discussionmentioning
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“…Furthermore the described differences in the excitation-contraction coupling still remain intact in nonpermeabilized preparations. And additionally the calcium sensitivity is species dependent [ 21 - 24 ]. A potential correlation of sex, cardiac disease and disease progression obviously exists, but it is still not known how sex influences the signaling pathways, which impacts the contractile properties [ 2 ].…”
Section: Discussionmentioning
“…As one would expect, these transition regions exhibit markedly different material and mechanical properties than at either end of the transition where the tissue is 'pure' LL, CT or PM. In structure, PM resembles skeletal muscles and the cellular arrangement is markedly different from the packing exhibited by cardiac muscles, as indicated by the average sarcomere length [6][7][8]. For more information regarding comparisons of sarcomere lengths, see SI Table S1.…”
Section: Heart Tissue Organization and Cardiac Injurymentioning
“…The application of cardioplegic solution combined with external cooling of the myocardium is used in cardiac surgery, aiming to protect the myocardium intraoperatively against damage caused by ischemia during the period of aortic cross -clamping (1, 3,4,5,11,25,26 ). Basically two types of cristalloid cardioplegic solutions are currently used in clinical practice : solutions with an intracellular formulation (4, 26) and cardioplegic solutions with an extracellular formulation (5).…”
Section: Introductionmentioning