Analyzing biomechanical parameters of the cornea with glaucoma severity in open-angle glaucoma

Pillunat, Karin R; Hermann, Cosima; Spoerl, Eberhard; Pillunat, Lutz E

doi:10.1007/s00417-016-3365-3

Cited by 36 publications

(40 citation statements)

References 40 publications

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“…) and the severity of the disease (Pillunat et al. ). Recent studies with the Corvis ST showed a reduced deformability of the cornea in glaucoma patients, even after adjusting for IOP and CCT (Salvetat et al.…”

Section: Discussionmentioning

confidence: 99%

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A new biomechanical glaucoma factor to discriminate normal eyes from normal pressure glaucoma eyes

Pillunat

Herber

Spoerl

et al. 2019

Acta Ophthalmologica

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Background To test the ability of the newly calculated Dresden biomechanical glaucoma factor (DBGF) based on dynamic corneal response (DCR) deformation and corneal thickness parameters, to discriminate between healthy and normal pressure glaucoma (NPG) eyes. Methods Seventy healthy and 70 NPG patients of Caucasian origin were recruited for this multicentre cross‐sectional pilot study, which included both eyes for analysis. Logistic regression analysis with generalized estimating equation (GEE) models to account for correlations between eyes and a threefold cross‐validation were performed to determine the optimal combination of Corvis ST parameters in order to separate normal from NPG eyes. Results The DBGF was calculated using 5 Corvis ST parameters, which showed the best discrimination power: deformation amplitude ratio progression, highest concavity time, pachymetry slope, the biomechanically corrected intraocular pressure and pachymetry. In a threefold cross‐validation, the receiver operating characteristic (ROC) curve confirmed an area under the curve (AUC) of 0.814 with a sensitivity of 76% and a specificity of 77% using a logit cut‐off value of a DBGF = 0.5. Conclusion The DBGF shows to be sensitive and specific to discriminate healthy from NPG eyes. Since diagnosis of NPG is often challenging, the DBGF may help with the differential diagnosis of NPG in daily clinical practice. Therefore, it might be considered as a new possible screening method for NPG.

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Section: Discussionmentioning

confidence: 99%

“…) as well as the severity of the disease (Pillunat et al. ). The second one is the Corvis ST (Corneal visualization Scheimpflug Technology, Oculus GmbH, Weztlar, Germany), where the response of the cornea to an air pulse is monitored using an ultra‐high‐speed Scheimpflug camera.…”

Section: Introductionmentioning

confidence: 99%

A new biomechanical glaucoma factor to discriminate normal eyes from normal pressure glaucoma eyes

Pillunat

Herber

Spoerl

et al. 2019

Acta Ophthalmologica

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“…Glaucoma severity was classified as mild (MD < 6.00 dB), moderate (12 dB > MD ≥6 dB), and severe (MD ≥12 dB) based on the MD [24][25][26][27]. Therefore, POAG patients were categorized into 3 subgroups of different severity level, of which 92 were classified as mild, 56 as moderate, and 92 as severe.…”

Section: Comparison Of Clinical Parameters Of Poag Patients Stratifiementioning

confidence: 99%

Associations between Blood Cell Profiles and Primary Open-Angle Glaucoma: A Retrospective Case-Control Study

Tang

Han

et al. 2020

Ophthalmic Res

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Purpose: We aimed to evaluate whether the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune inflammation index (SII) were associated with primary open-angle glaucoma (POAG). Materials and Methods: This retrospective case-control study included 240 patients with POAG and 300 age- and sex-matched control subjects. Complete ophthalmological examination and blood count measurements were performed for all subjects. Results: The values of NLR, PLR, and SII in the POAG group were significantly increased compared with the control group (p < 0.001; p = 0.012; p < 0.001). However, the LMR value was lower in the POAG patients than in the control group (p < 0.001). When we divided the subjects into different age and gender subgroups, the NLR and SII values in the POAG patients were always higher than those in the control group. In the comparison of laboratory parameters in POAG subjects stratified according to severity, we also found that NLR and SII increased with the severity. The receiver operating characteristic (ROC) analysis revealed that the areas under the ROC curve of NLR, PLR, LMR, and SII to predict patients with POAG were found to be 0.627, 0.569, 0.382, and 0.986, respectively. The best cutoff point of NLR was 1.998 with a sensitivity of 59.8% and a specificity of 63.0%, and the SII was 947.365 with a sensitivity of 95.4% and a specificity of 95.7%. Multivariable logistic regression analysis showed that NLR was positively associated with mean deviation; moreover, NLR and SII were independent indicators correlated with POAG (OR 1.502; 95% CI 1.227–1.839; p < 0.001; OR 1.02; 95% CI 1.009–1.021; p < 0.001). Conclusion: We speculated that elevated NLR and SII might serve as readily available inflammatory predictors in POAG patients.

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“…15,16 Ayrıca, KH ve KRF'nin keratokonus hastalarında, psödofakik gözlerde, Fuchs kornea distrofisinde, primer açık açılı glokom ve normal basınçlı glokom hastalarında daha düşük olduğu gösterilmiştir. [19][20][21][22] Akromegali hastalarında korneanın biyomekanik özelliklerinin OCA ile değerlendirildiği önceki çalışmalar incelendiğinde, Özkök ve ark. ile Altınkaynak ve ark., KH ve KRF değerlerini akromegali hastalarında anlamlı olarak yüksek bulur iken; Şen ve ark., KH ve KRF değerlerini akromegali hasta grubunda daha yüksek ölçmüş, ancak aradaki farkı istatistiksel olarak anlamlı bulmamışlardır.…”

Section: Bulgularunclassified

Corneal Biomechanical Properties in Patients with Acromegaly

İnanç¹,

Şimşek²,

Beyazyıldız³

et al. 2018

Turkiye Klinikleri J Ophthalmol

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kromegali, büyüme hormonu (BH) düzeylerinde artış ile seyreden nadir görülen bir hastalıktır. Hastaların %90'ından fazlasında altta yatan hipofiz bezi tümörü mevcuttur. 1 Akromegali hastalarında bulgular fazla salgılanan BH ve/veya tümörün bası etkisine bağlı olarak karşımıza çıkabilmektedir. Yükselen BH ve buna sekonder karaciğerden salınımı artan insülin benzeri büyüme faktörü-1 [insulin-like growth factor (IGF-1)] hücre proliferasyonunu tetiklemekte, apoptozu ise inhibe etmektedir. Bunun sonucunda hastalarda akral büyüme, büyük, geniş dudak ve burun Turkiye Klinikleri J Ophthalmol 2018;27(4):279-83 279 Akromegali Hastalarında Korneal Biyomekanik Özellikler Ö ÖZ ZE ET T A Am ma aç ç: : Akromegali tanısıyla izlenen hastalarda korneanın biyomekanik özelliklerinin oküler cevap analizörü (OCA) ile belirlenmesi ve sağlıklı kontrol grubu ile karşılaştırılmasıdır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya 32 akromegali hastası ile yaş ve cinsiyeti eşleştirilmiş 30 kontrol vakası dâhil edildi. Korneal histerez (KH), korneal rezistans faktör (KRF), Goldmann korele göz içi basıncı (GİBg) ve korneal kompanze edilmiş göz içi basıncı (GİBkk) değerleri OCA ile ölçüldü. Santral kornea kalınlıkları (SKK) ultrasonik pakimetre ile belirlendi ve gruplar arası farklar karşılaştırıldı. B Bu ul lg gu ul la ar r: : Akromegalik gözler ile sağlıklı gözlerde bakılan OCA değerleri sırasıyla; KH için 10,35±1,65 mmHg ve 9,17±1,51 mmHg, KRF için 10,35±2,01 mmHg ve 9,04±1,58 mmHg, SKK için 546,81±34,7 ve 521,9±37,1 idi. Akromegali hasta grubunda, sağlıklı bireylere göre ortalama KH, KRF ve SKK değerleri daha yüksek bulundu. Ortalama GİBg ve GİGkk değerleri açısından hasta ve kontrol grubu arasında istatistiksel olarak anlamlı farklılık yoktu. S So on nu uç ç: : Akromegali hastalığı multisistemik tutulum ile seyrederken, korneada da biyomekanik değişikliklere neden olmaktadır. Korneal elastikiyet ve dirençte meydana gelen değişiklikler ile KH, KRF ve SKK değerlerinde anlamlı değişim gözlemlenmiştir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Akromegali; korneal biyomekanik; oküler cevap analizörü A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : We aimed to determine the biomechanical properties of the cornea with ocular response analyzer (ORA) and to compare it with the healthy control group in cases with acromegaly diagnosis. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Thirty-two patients with acromegaly and 30 age-and sex-matched control subjects were included in the study. Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg) and cornea-compensated intraocular pressure (IOPcc) values were measured by ORA. Central corneal thickness (CCT) was determined by ultrasonic pachymeter and the differences between the groups were compared. R Re e-s su ul lt ts s: : ORA values measured in acromegalic eyes and healthy eyes were 10.35±1.65 mmHg and 9.17±1.51 mmHg for CH, 10.35±2.01 mmHg and 9.04±1.58 mmHg for CRF, 546.81±34.7 and 521.9±37.1 ...

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Analyzing biomechanical parameters of the cornea with glaucoma severity in open-angle glaucoma

Cited by 36 publications

References 40 publications

A new biomechanical glaucoma factor to discriminate normal eyes from normal pressure glaucoma eyes

A new biomechanical glaucoma factor to discriminate normal eyes from normal pressure glaucoma eyes

Associations between Blood Cell Profiles and Primary Open-Angle Glaucoma: A Retrospective Case-Control Study

Corneal Biomechanical Properties in Patients with Acromegaly

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