Analytical Evidence

and, Amit Bhattacharya; Ray, Paramita

doi:10.1002/9780470414811.ch4

Cited by 2 publications

(3 citation statements)

References 41 publications

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“…Preparation of Agar Agar-g-Polyacrylic Acid (AA-g-AcA) and Agar Agar-g-Polymethacrylic Acid (AA-g-McA) Polymers Ag-g-AcA and AA-g-McA were synthesized by graft polymerization using cerium ammonium nitrate (CAN) as a free radical initiator in an inert nitrogen atmosphere. By direct oxidation, CAN generates free radicals on the agar backbone [17]. Graft copolymers are generated in the presence of these active free radicals and the presence of acrylic or methacrylic acid.…”

Section: Resultsmentioning

confidence: 99%

“…Graft polymers are usually obtained through the use of initiators or gamma ray, UV, or microwave radiation in order to create a free radical site on the polymer chain. Monomeric units are attached similarly to a side chain to a polymer backbone to form a branched polymer with desirable properties non-intrinsic for the base polymer [17]. In regard to the pH-sensitive delivery, specific polymers which change their physicochemical properties based on the change in the pH can be utilized.…”

Section: Introductionmentioning

confidence: 99%

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Agar Graft Modification with Acrylic and Methacrylic Acid for the Preparation of pH-Sensitive Nanogels for 5-Fluorouracil Delivery

Ivanova,

Slavkova,

Popova

et al. 2024

Gels

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Agar, a naturally occurring polysaccharide, has been modified by grafting it with acrylic (AcA) and methacrylic (McA) acid monomers, resulting in acrylic or methacrylic acid grafted polymer (AA-g-AcA or AA-g-McA) with pH-sensitive swelling behavior. Different ratios between agar, monomers, and initiator were applied. The synthesized grades of both new polymer series were characterized using FTIR spectroscopy, NMR, TGA, DSC, and XRD to ascertain the intended grafting. The percentage of grafting (% G), grafting efficiency (% GE), and % conversion (% C) were calculated, and models with optimal characteristics were further characterized. The swelling behavior of the newly synthesized polymers was studied over time and in solutions with different pH. These polymers were subsequently crosslinked with varying amounts of glutaraldehyde to obtain 5-fluorouracil-loaded nanogels. The optimal ratios of polymer, drug, and crosslinker resulted in nearly 80% loading efficiency. The performed physicochemical characterization (TEM and DLS) showed spherical nanogels with nanometer sizes (105.7–250 nm), negative zeta potentials, and narrow size distributions. According to FTIR analysis, 5-fluorouracil was physically incorporated. The swelling and release behavior of the prepared nanogels was pH-sensitive, favoring the delivery of the chemotherapeutic to tumor cells. The biocompatibility of the proposed nanocarrier was proven using an in vitro hemolysis assay.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Agar Graft Modification with Acrylic and Methacrylic Acid for the Preparation of pH-Sensitive Nanogels for 5-Fluorouracil Delivery

Ivanova,

Slavkova,

Popova

et al. 2024

Gels

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show abstract

“…Rheology is concerned with the study of the deformation and flow of matter, when a mechanical stress is applied, and the studied parameters include the viscosity, elasticity, shear rate, shear strain and shear stress [154][155][156][157] .…”

Section: Rheology Principles and Rheo-salsmentioning

confidence: 99%

Interactions between ethyl(hydroxyethyl) cellulose and lysine-based surfactants in aqueous media

Calejo

Kjøniksen

Marques

et al. 2012

European Polymer Journal

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for all the guidance throughout this journey. I cannot thank you enough for all your unlimited support and encouragement, and for all the productive discussions. Thank you so much for believing in me and for making me feel so appreciated. I am deeply grateful to Professor Amália Jurado and Professor Maria da Conceição Lima, who accepted my stay in the laboratories of the Center for Neuroscience and Cell Biology, University of Coimbra. The time I spent in Coimbra was both extremely intense and fruitful, and I feel profoundly privileged for having enjoyed this experience. Thank you for your kindness and support. I would like to express my deep gratitude to Ana Maria Cardoso for her support in the laboratories in Coimbra, for her unlimited patience and encouragement. Thank you for always being there for me. You are a wonderful friend.

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Analytical Evidence

Cited by 2 publications

References 41 publications

Agar Graft Modification with Acrylic and Methacrylic Acid for the Preparation of pH-Sensitive Nanogels for 5-Fluorouracil Delivery

Agar Graft Modification with Acrylic and Methacrylic Acid for the Preparation of pH-Sensitive Nanogels for 5-Fluorouracil Delivery

Interactions between ethyl(hydroxyethyl) cellulose and lysine-based surfactants in aqueous media

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