Analytical and physical optimization of nanohole-array sensors prepared by modified nanosphere lithography

Murray-Méthot, Marie-Pier; Menegazzo, Nicola; Masson, Jean-François

doi:10.1039/b808820a

Cited by 44 publications

(71 citation statements)

References 32 publications

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“…A nanohole array modified SPR chip was fabricated according to the method described by Masson et al [39–40]. Drop casting of the polystyrene particles on a clean glass slide leads to a densely packed monolayer on the substrate (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Graphene-enhanced plasmonic nanohole arrays for environmental sensing in aqueous samples

Genslein¹,

Hausler²,

Kirchner³

et al. 2016

Beilstein J. Nanotechnol.

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The label-free nature of surface plasmon resonance techniques (SPR) enables a fast, specific, and sensitive analysis of molecular interactions. However, detection of highly diluted concentrations and small molecules is still challenging. It is shown here that in contrast to continuous gold films, gold nanohole arrays can significantly improve the performance of SPR devices in angle-dependent measurement mode, as a signal amplification arises from localized surface plasmons at the nanostructures. This leads consequently to an increased sensing capability of molecules bound to the nanohole array surface. Furthermore, a reduced graphene oxide (rGO) sensor surface was layered over the nanohole array. Reduced graphene oxide is a 2D nanomaterial consisting of sp2-hybridized carbon atoms and is an attractive receptor surface for SPR as it omits any bulk phase and therefore allows fast response times. In fact, it was found that nanohole arrays demonstrated a higher shift in the resonance angle of 250–380% compared to a continuous gold film. At the same time the nanohole array structure as characterized by its diameter-to-periodicity ratio had minimal influence on the binding capacity of the sensor surface. As a simple and environmentally highly relevant model, binding of the plasticizer diethyl phthalate (DEP) via π-stacking was monitored on the rGO gold nanohole array realizing a limit of detection of as low as 20 nM. The concentration-dependent signal change was studied with the best performing rGO-modified nanohole arrays. Compared to continuous gold films a diameter-to-periodicity ratio (D/P) of 0.43 lead to a 12-fold signal enhancement. Finally, the effect of environmental waters on the sensor was evaluated using samples from sea, lake and river waters spiked with analytically relevant amounts of DEP during which significant changes in the SPR signal are observed. It is expected that this concept can be successfully transferred to enhance the sensitivity in SPR sensors.

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Section: Resultsmentioning

confidence: 99%

“…The fabrication of nanohole arrays consists of several steps [39–40]. First a sphere mask of a hexagonal, closed packed, two dimensional crystal of polymer particles needs to be formed via self-assembly by a slow evaporation process.…”

Section: Methodsmentioning

confidence: 99%

Graphene-enhanced plasmonic nanohole arrays for environmental sensing in aqueous samples

Genslein¹,

Hausler²,

Kirchner³

et al. 2016

Beilstein J. Nanotechnol.

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show abstract

“…13,18,40 In short, the cover slips were sonicated in acetone for 5 min followed by sonication for 15 min in a Nochromix solution prepared with concentrated sulphuric acid. Once completed, the cover slips and beakers were rinsed thoroughly with Milli-Q ultrapure water (18.2 M⍀-cm).…”

Section: Platform Fabricationmentioning

confidence: 99%

“…[6][7][8][9][10][11][12][13][14] To effectively use SERS in analytical measurements, the conception and the fabrication of SERS structures that provide reproducible and stable measurements is critical. 15 A variety of structures such as nanorings, 16 spherical nanoshells, 17 spherical nanoholes, 18 nanocubes, 19 nanorods, 20 nanopyramids, 21,22 and nanotriangles 23 have successfully been tested. One factor that can influence the potential use of a SERS platform is the cost associated with the fabrication process.…”

Section: Introductionmentioning

confidence: 99%

Towards attomolar detection using a surface-enhanced Raman spectroscopy platform fabricated by nanosphere lithography

WallaceGregory

TabatabaeiMohammadali

Lagugné-LabarthetFrançois

2014

Can. J. Chem.

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The limit of detection of 4-nitrothiophenol adsorbed onto the surface of a platform fabricated by nanosphere lithography is investigated by surface-enhanced Raman spectroscopy. Critical factors such as the functionalization time and the change of sharpness of the gold nanostructures upon annealing are studied. Platforms for surface-enhanced Raman spectroscopy provide detection ranging from monolayers down to isolated molecules. For a functionalization time of 24 h, a limit of detection of 10 −16 mol/L (100 amol/L) is achieved. Furthermore, by shortening the functionalization time to 30 min, a significantly higher limit of detection is determined ranging from 10 −6 to 10 −9 mol/L. By altering the shape of the nanotriangles via annealing, a loss in signal intensity occurs. Optimizing the factors that enable a lower limit of detection is critical for many applications where surface-enhanced Raman spectroscopy can be considered as a promising analytical alternative.Résumé : La limite de détection du 4-nitrothiophenol adsorbé à la surface de substrats optimisés pour la diffusion Raman exaltée de surface fabriqués par lithographie à base de nanosphères est déterminée. Les facteurs critiques tels que la durée de fonctionnalisation ainsi que la forme des nanostructures en or après recuit thermique sont étudiés. De telles plateformes permettent la détection allant, en moyenne, de couches mono-moléculaires jusqu'à quelques molécules isolées. Pour une durée de fonctionnalisation de 24 h, une limite de détection allant jusqu'à 10 −16 mol/L (100 amol/L) est atteinte. En revanche, la diminution de la durée de fonctionnalisation à 30 min accroît en revanche la limite de détection à des concentrations de 10 −6 to 10 −9 mol/L. En modifiant la forme des nano-triangles par recuit, une décroissance du signal Raman est observée. L'optimisation des facteurs déterminant une basse limite de détection est critique pour de nombreuses applications en chimie analytique impliquant des mesures de diffusion Raman exaltée de surface.Mots-clés : diffusion Raman exaltée de surface, 4-nitrothiophenol, lithographie à base de nanosphères, limite de détection, détection attomolaire.

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“…44 Preparation of Aminated Coverslips Clean coverslips were prepared through several washing steps. 45,46 First, each coverslip was thoroughly washed in acetone and ethanol in an ultrasonic bath for 30 min, respectively. Then, the coverslips were cleaned in piranha solution (3 : 1 H 2 SO 4 /30% H 2 O 2 ) at 90 C for 1 h. Afterward, the coverslips were placed in a solution of 5 : 1 : 1 H 2 O/NH 4 OH/30% H 2 O 2 , and sonicated for 1.5 h. The coverslips were washed thoroughly and sonicated in plenty of deionized water for several times.…”

Section: Fluorescence Image Of Sa-modified Microparticles By Confocalmentioning

confidence: 99%

Synthesis and application of streptavidin functionalized organosilica microparticles

Hou

Zhang

Wang

et al. 2014

J of Applied Polymer Sci

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This article reports on the chemical synthesis, functionalization and application of streptavidin (SA)-coated organosilica microparticles. Thiol-functionalized organosilica microparticles are synthesized via a two-step approach involving acid-catalyzed hydrolysis and condensation of 3-mercaptopropyl trimethoxysilane (MPS), followed by base-catalyzed condensation. The surfaces of these particles are modified with 3-aminopropyltriethoxysilane (APS), and characterized by FTIR, XPS, and TGA. Then, APSfunctionalized microparticles are covalently coated with SAs by using glutaraldehyde as a coupling agent, and characterized by FTIR, SEM, and AFM. Immobilization of biotinylated k DNA onto microparticles via SA-biotin immuoreaction is confirmed by confocal microscopy. The results show that these SA-functionalized organosilica microparticles are useful carriers for DNA manipulation at the single molecule level.

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Analytical and physical optimization of nanohole-array sensors prepared by modified nanosphere lithography

Cited by 44 publications

References 32 publications

Graphene-enhanced plasmonic nanohole arrays for environmental sensing in aqueous samples

Graphene-enhanced plasmonic nanohole arrays for environmental sensing in aqueous samples

Towards attomolar detection using a surface-enhanced Raman spectroscopy platform fabricated by nanosphere lithography

Synthesis and application of streptavidin functionalized organosilica microparticles

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