Analyte-triggered citrate-stabilized Au nanoparticle aggregation with accelerated peroxidase-mimicking activity for catalysis-based colorimetric sensing of arsenite

Xue, Qiangsheng; Niu, Xiangheng; Liu, Peng; Wang, Mengzhu; Peng, Yinxian; Peng, Hongbing; Li, Xin

doi:10.1016/j.snb.2021.129650

Cited by 36 publications

(13 citation statements)

References 60 publications

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“…A Hill coefficient of 0.63 implies a cooperative interaction for the binding event between the arsenite ion and its specific aptamer, suggesting a relatively high reactivity between the aptamer and arsenite ions . An LOD of 0.02 ppb was achieved based on the “3σ” rule, more than 2 orders of magnitude lower than previous reports based on the labeling approaches , and a World Health Organization tolerance level of 10 ppb.…”

Section: Resultsmentioning

confidence: 76%

Aptasensors Based on Graphene Field-Effect Transistors for Arsenite Detection

Tyagi

Huang

et al. 2022

ACS Appl. Nano Mater.

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All-electronic chemical sensors based on field-effect transistors (FETs) hold tremendous promise for rapid and sensitive detection of arsenic in groundwater. Their sensitivity, however, is fundamentally limited by a chemical gating mechanism where target ion charges are directly measured. We have developed a highly sensitive aptasensor, based on scalable graphene FETs, which relies on the conformational change of the negatively charged aptamer upon arsenite binding, offering a wide analytical range, from 0.05 to 1000 ppb, and with a 0.02 ppb detection limit. Circular dichroism spectroscopy studies confirmed the conformational change of the aptamer, and molecular dynamic studies further validated that arsenite had bound with the hairpin loop of the aptamer. This work provides a highly accurate chemical sensing platform for rapid detection of arsenic in drinking water.

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Section: Resultsmentioning

confidence: 76%

Aptasensors Based on Graphene Field-Effect Transistors for Arsenite Detection

Tyagi

Huang

et al. 2022

ACS Appl. Nano Mater.

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“…First, citrate-stabilized AuNPs were synthesized according to a previous report with some modifications. 32 Briefly, 5 mL of HAuCl 4 (10 mM) was brought to a boil with vigorous stirring. Two minutes later, 5 mL of sodium citrate (38.8 mM) was added to the solution.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Electrocatalysis of Copper Sulfide Nanoparticle-Engineered Covalent Organic Frameworks for Ratiometric Electrochemical Detection of Amyloid-β Oligomer

et al. 2022

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Amyloid-β oligomer (AβO) is widely regarded as a reliable biomarker for the early diagnosis of Alzheimer’s disease (AD). In this study, a signal on–off ratiometric electrochemical immunosensor has been developed for ultrasensitive detection of AβO. To achieve the dual-signal ratiometric strategy, ultrasmall copper sulfide nanoparticle-engineered covalent organic framework hybrid nanocomposites (CuS@COFs) were utilized as excellent electrocatalysts toward hydroquinone (HQ) oxidation to produce detectable signals. Meanwhile, electroactive thionine (Thi) and Aβ antibody-modified gold nanoparticles (Thi-AuNPs-Ab bioconjugates) were designed as another electrochemical indicator. Based on these two signals, an ultrasensitive sandwich-like electrochemical immunosensor was established for AβO detection. The introduction of AβO resulted in a remarkable decline in the electrochemical signal of HQ but an increase in the signal of Thi. Under optimum conditions, the ratios between the double signals (I Thi/I HQ) showed a proportional linear relationship with the AβO concentration (1 pM–1 μM) with a low detection limit of 0.4 pM (S/N = 3), and the biosensor was able to determine the content of AβO in real cerebrospinal fluid samples with satisfactory results. The ratiometric strategy proposed in our study offers a sensitive and efficient approach for early diagnosis of AD, and this work will promote the further applications of engineered COFs in electrochemical sensors.

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“…In comparison with other analytical techniques, the colorimetric sensing strategy based on gold nanoparticle (AuNP)nanozymes has numerous benefits including simple oper-ation, green process, 5,6 convenient control and reliable application. Dozens of compounds, such as amino acids, [7][8][9] DNA, 10 organic acids 11 and proteins, [12][13][14] can be utilized as ligands for the preparation of AuNPs, which have demonstrated their enzyme-like catalytic activities in the 3,3′,5,5′-tetramethylbenzidine (TMB)-hydrogen peroxide (H 2 O 2 ) system for the testing of drugs. 15 However, few studies are concerned with the polymer-protected AuNPs ( polymer@AuNPs) as nanozymes for sensing applications.…”

Section: Introductionmentioning

confidence: 99%