Analysis of31P MR spectroscopy data using artificial neural networks for longitudinal evaluation of musclediseases: dermatomyositis

Muscle metabolism in patients with polymyositis simultaneously evaluated by using 31P-magnetic resonance spectroscopy and near-infrared spectroscopy

“…Decreased PCr index and pHi in PM patients before steroid therapy are relieved after therapy (15). In Cea et al (16) in vivo findings in dermatomyositis and PM patients indicate impaired muscle aerobic function, which, considering the reduced proton Before steroid therapy, PM patients had markedly lower intracellular pH (pHi) during exercise and made a slower recovery than normal individuals, with statistically significant differences between the time courses in patients and controls.…”

A case report of ineffective immunosuppressive therapy for MDA5 related clinically amyopathic dermatomyositis during pregnancy and literature review

“…Since CADM often complicates with life-threatening RP-ILD, initial therapies tend to focus on treating lung involvement, and pulmonary function should be closely monitored. Treatments for RP-ILD are usually empirical and often involve high-dose corticosteroid therapy ( 33 ). There is no consensus on optimal treatment of CADM.…”

Pathogenesis of Muscle Weakness in Inflammatory Myositis

“…[116] Study on muscle biopsy postresistance exercise for 7 weeks showed decrease in the serum C1q levels; decreased transforming growth factor (TGF-β) signaling along with TGF-β 1R, connective tissue growth factor, and fibroblast growth factor; and increased expression of latent-TGF beta-binding protein. [96] This evidence suggests a role for exercise in preventing muscle damage and fibrosis, through the TGF-β pathway. Exercise also suppresses synthesis of collagen and other Extracellular matrix (ECM) components.…”

“…[94,95] In IIM, 31P-MRS demonstrated variations in muscle energy metabolites such as inorganic phosphate, phosphocreatine (PCr), ATP, phosphodiesters, and pH before and after exercise. [21,96,97] In adults with PM/DM, levels of PCr and ATP were reduced at resting state, and these findings were further exacerbated following exercise. [98] This reflects overall low-energy state possibly due to compromised vasculature or due to abnormal mitochondrial function in myositis.…”