Analysis of β-agonists and β-blockers in urine using hollow fibre-protected liquid-phase microextraction with in situ derivatization followed by gas chromatography/mass spectrometry

Liu, Wei; Zhang, Lan; Wei, Zhenyi; Chen, Shengping

doi:10.1016/j.chroma.2009.05.040

Cited by 68 publications

(39 citation statements)

References 46 publications

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“…The processing method lead to satisfactory results for the separation of metoprolol from human urine samples obtained following a single dose administration. The extraction recovery was found between 93.79-109.04% [21].…”

Section: Liquid-liquid Microextractionmentioning

confidence: 88%

“…The small amount of analytes at nanogram and picogram levels led to the development of new techniques for biological sample processing, such as dispersive liquid-liquid microextraction (DLLME) [29], carrier-mediated liquid phase microextraction (CM-LPME) [24], hollow fibre-protected liquid phase microextraction (HF-LPME) [21] and on-line molecularly imprinted solid phase extraction [32].…”

Section: Biological Sample Preparationmentioning

confidence: 99%

“…These methods include liquid chromatography coupled with mass spectrometry (LC-MS/MS) [7][8][9][10][11][12][13][14][15][16][17], liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS/MS) [18,19], gas chromatography coupled with mass spectrometry (GC-MS) [3,[20][21][22], high performance liquid chromatography (HPLC) [23,24], high performance liquid chromatography coupled with mass spectrometry (HPLC-MS) [25,26], high performance liquid chromatography with fluorescence detection (HPLC-FLD) [2,27,28], high performance liquid chromatography coupled with ultraviolet detection (HPLC-UV) [29], reversed-phase ultra-high-performance liquid chromatography coupled with mass spectrometry (UHPLC-MS) [30].…”

Section: Introductionmentioning

confidence: 99%

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Preparation of Biological Samples Containing Metoprolol and Bisoprolol for Applying Methods for Quantitative Analysis

Corina¹,

Hăncianu²,

Agoroaei³

et al. 2015

Acta Medica Marisiensis

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Arterial hypertension is a complex disease with many serious complications, representing a leading cause of mortality. Selective beta-blockers such as metoprolol and bisoprolol are frequently used in the management of hypertension. Numerous analytical methods have been developed for the determination of these substances in biological fluids, such as liquid chromatography coupled with mass spectrometry, gas chromatography coupled with mass spectrometry, high performance liquid chromatography. Due to the complex composition of biological fluids a biological sample pre-treatment before the use of the method for quantitative determination is required in order to remove proteins and potential interferences. The most commonly used methods for processing biological samples containing metoprolol and bisoprolol were identified through a thorough literature search using PubMed, ScienceDirect, and Willey Journals databases. Articles published between years 2005-2015 were reviewed. Protein precipitation, liquid-liquid extraction and solid phase extraction are the main techniques for the extraction of these drugs from plasma, serum, whole blood and urine samples. In addition, numerous other techniques have been developed for the preparation of biological samples, such as dispersive liquid-liquid microextraction, carrier-mediated liquid phase microextraction, hollow fiber-protected liquid phase microextraction, on-line molecularly imprinted solid phase extraction. The analysis of metoprolol and bisoprolol in human plasma, urine and other biological fluids provides important information in clinical and toxicological trials, thus requiring the application of appropriate extraction techniques for the detection of these antihypertensive substances at nanogram and picogram levels.

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Section: Liquid-liquid Microextractionmentioning

confidence: 88%

Section: Biological Sample Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation of Biological Samples Containing Metoprolol and Bisoprolol for Applying Methods for Quantitative Analysis

Corina¹,

Hăncianu²,

Agoroaei³

et al. 2015

Acta Medica Marisiensis

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“…To further dissect potential mechanisms, we next focused on the APC-Siglec-G interaction because CD24 directly binds a broad range of DAMPs, and also binds to Siglec-G and then represses the responses to DAMPs (7,8,21). We hypothesized that if the APC CD24 interaction with donor T cell Siglec-G is critical, then the absence of CD24 on host APCs would enhance GVHD.…”

Section: Interaction Of Siglec-g On T Cells With Cd24 Is Critical Formentioning

confidence: 99%

Siglec-G represses DAMP-mediated effects on T cells

Toubai¹,

Rossi²,

Oravecz-Wilson³

et al. 2017

JCI Insight

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“…This coupling improved chromatographic separation, sensitivity and selectivity of analytes 127 . Generally, the coupling can be carried out in several ways 127,136 .…”

Section: Hollow Fiber Liquid Phase Microextractionmentioning

confidence: 99%

Chemical Derivatization Processes Applied to Amine Determination in Samples of Different Matrix Composition

et al. 2015

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Analysis of β-agonists and β-blockers in urine using hollow fibre-protected liquid-phase microextraction with in situ derivatization followed by gas chromatography/mass spectrometry

Cited by 68 publications

References 46 publications

Preparation of Biological Samples Containing Metoprolol and Bisoprolol for Applying Methods for Quantitative Analysis

Preparation of Biological Samples Containing Metoprolol and Bisoprolol for Applying Methods for Quantitative Analysis

Siglec-G represses DAMP-mediated effects on T cells

Chemical Derivatization Processes Applied to Amine Determination in Samples of Different Matrix Composition

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