Analysis of Treatment Results of the Thoracic Part of Oesophageal Cancer

Abstract

AIM:This study aims to evaluate the methods of treatment of the thoracic part of oesophagal cancer and to predict the results of treatment depending on the factors of the prognosis.MATERIALS AND METHODS:The results of treatment of 366 patients with cancer of the thoracic part of the oesophagus for 10 years (2007-2016) by the department of thoracic oncology of the Karaganda oncological dispensary were studied.RESULTS:The overall five-year survival rate, regardless of the method of treatment, was only 8.72% (28 of 321), and in the 6-10 year period 8.41% (27 of 321) lived, p < 0.05. Analysis of the overall survival of patients with cancer of the thoracic part of oesophagus showed that the method of treatment does not have a significant effect on life expectancy. A multivariate analysis of 19 grades that affect the prognosis of the disease was carried out.CONCLUSION:Radical type of treatment of the middle and lower thoracic oesophagus is surgical, in which the median of cumulative survival is 19 months. Traditional radiotherapy should be used in a limited way, as it is palliative, with a median survival of no more than 9 months. The leading factor in the prognosis for thoracic part of oesophagal cancer is the presence of regional metastases, on which the choice of method of treatment depends.

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“…The early symptoms of esophageal cancer are not obvious, and most patients are already in the middle and late stages when they are found. Because there are abundant large blood vessels and lymph nodes around the esophagus, its invasiveness is strong, and it has a high recurrence and metastasis rate, so the prognosis of esophageal cancer patients is poor and the survival rate is low, and its 5-year survival rate is 15-25%, which is one of the four major causes of in-hospital death in China [6][7][8]. Currently, the treatment of esophageal cancer is based on surgical resection as the main treatment method, combined with integrated treatment methods such as radiotherapy, chemotherapy, and immunotherapy.…”

Clinical characteristics and survival of 5283 esophageal cancer patients: A multicenter study from eighteen hospitals across six regions in China

“…The main treatments for EC are surgical resection, radiotherapy, and chemotherapy. Although great progress has been made in the treatment of EC, its prognosis is still poor, with a 5-year survival rate below 25% [6].…”

“…Many studies related to EC survival in recent years mainly focused on treatment methods including surgery [6], radiotherapy [7], and chemotherapy [8]. For instance, Spence et al [9] found that low-dose aspirin usage did not increase the survival of EC patients.…”