Analysis of the coxsackievirus B-adenovirus receptor gene in patients with myocarditis or dilated cardiomyopathy

Comparison of the Clinical Presentation, Treatment, and Outcome of Fulminant and Acute Myocarditis in Children

“…13 Although increased expression of the common human CB-adenovirus receptor has also been reported in MC and DCM, the CB-adenovirus receptor was not found to be a major host determinant in the development of MC and DCM. 14 MC caused by infection with human parvovirus B19 (PV-B19) has been reported in infants with MC, 15 and the PV B19 genome was predominant in patients with unexplained isolated diastolic ventricular dysfunction. 16 PV-B19 is associated Table 2.…”

The Coxsackievirus and Adenovirus Receptor: A new adhesion protein in cochlear development

“…Although the CAR P356S mutation had no effect on localization or adenovirus infection efficiency, we hypothesized that it may have a significant effect on PDZ-based Bowles et al (2002) A-G Q111Q <0.006 Bowles et al (2002) G-A V133V <0.006 Bowles et al (2002) A-G T288T 0.5/0.5…”

“…There were no polymorphisms within the extracellular domain of CAR that interacts with adenovirus (Thoelen et al, 2002). Bowles and colleagues did find three silent coding mutations in their study of 94 patients with myocarditis or dilated cardiomyopathy (Bowles et al, 2002), suggesting that mutations in the coding region of CXADR are rare.…”

Viral Myocarditis

“…As far as we know, a significant relationship between CAR polymorphisms and the development of myocarditis and DCM has not been identified. 48 …”