Analysis of the Bispectral Index During Natural Sleep in Children

Abstract

The Bispectral Index (BIS) is a system used to measure sedation levels. Some investigators recently analyzed changes in the BIS during natural sleep in adults and found that the BIS diminished considerably as sleep became deeper. No such studies have been undertaken to investigate changes in the BIS in sleeping children. The aim of this work was to assess the trend of the BIS in the various stages of sleep in a group of children, performing a descriptive analysis on a limited number of cases. We evaluated 15 children with negative clinical findings and a normal electroencephalogram (EEG) as part of their follow-up for prior episodes of epilepsy, recording the BIS and EEG in a waking state, in the various stages of sleep and on reawaking. For each stage, the mean value, the standard deviation, and the range of BIS values were calculated. The results showed that the BIS decreased progressively as sleep became deeper. The correlation between the stage of sleep and the BIS was significant. On reawaking, a slow increase was apparent in the BIS.

¿Existe un valor de índice biespectral adecuado para endoscopias digestivas altas en respiración espontánea en el paciente pediátrico?

“…Al respecto, resulta interesante el trabajo de Benini et al 16 , que en pacientes pediátricos sanos estudiaron el valor del BIS en distintas fases del sueño fisiológico (no inducido farmacológicamente), con hallazgo de valores de BIS en el rango 20-30 en las fases más profundas de sueño, sin evidencia de desaturación.…”

Monitoring sedation in the critically ill child

“…The BIS values are significantly higher when the patient is awake than during sleep [34]; they gradually decrease as the depth of sleep increases, and can reach values of 40 or 45 [35]. The BIS is able to detect changes in a child's conscious level independently of the cause, but cannot discriminate between natural and drug-induced sleep.…”

Inhalation and intravenous anesthesia in pediatric patients

“…B. BIS ® oder Narcotrend ® ) kann bei Patienten im Alter ab einem Jahr klinisch interpretierbar eingesetzt werden. Es werden Aussagen über die Hypnose und nicht die eigentliche Anäs-thesietiefe gemacht, denn auch im Nachtschlaf sind durchaus sehr tiefe Werte anzutreffen [9]. Tiefe BIS ® -Werte garantie- …”