Analysis of the antimicrobial and antibiotic activity of nanoparticles for endodontic use

Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review

“…The presence of large degrees of uninstrumented areas within the root canal and reactive/caustic nature of NaOCl has necessitated the need for advanced antimicrobial strategies that can be effective against bacteria within these uninstrumented portions of the root canals while displaying minimal cytotoxic effects [ 35 ]. Nanoparticle-based therapeutic approaches are one such strategy that has the potential to improve the antibacterial and anti-biofilm efficacy in root canal therapy [ 36 , 37 , 38 ].…”

“…Silver is the most widely used metal nanomaterial for inhibiting several types of microorganisms and drug-resistant microorganisms [ 37 ]. Due to its significant antibacterial effects against both Gram-negative and Gram-positive pathogens, AgNP confer certain benefits in dentistry, especially for endodontic treatment [ 39 ].…”

“…AgNPs have received attention as effective disinfectants for addition to irrigants, intracanal medicaments, and root canal sealers due to their antibacterial activity against Staphylococcus aureus (S. aureus), E. faecalis , Bacillus pumilus , and Porphyromonas gingivalis ( P. gingivalis ) biofilms, resolution of periodontal, endodontic, or combined lesions, optimal analgesic and anti-inflammatory properties, and favorable biocompatibility. Incorporation of AgNPs in the composition of root-filling materials and mineral trioxide aggregate (MTA) has also been reported [ 37 , 40 , 41 , 42 , 43 ]. An in vitro study suggested that AgNPs enhanced or at least produced an equal effect in the resolution of root canal infection when compared with traditional disinfection methods [ 44 ].…”