Analysis of telomere attrition in bipolar disorder

Lima, Isabela; Barros, A.G.A.; Rosa, Daniela V.; Albuquerque, Maicon Rodrigues; Malloy-Diniz, Leandro Fernandes; Neves, Fernando Silva; Romano-Silva, Marco Aurélio; Miranda, Débora Marques de

doi:10.1016/j.jad.2014.09.043

Cited by 51 publications

(41 citation statements)

References 38 publications

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“…Full texts of 10 references were assessed, and 7 studies (Elvsashagen et al, 2011;Lima et al, 2014;Mansour et al, 2011;Rizzo et al, 2013;Simon et al, 2006;Zhang et al, 2010) were included in this meta-analysis (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…Evidence points to shortened telomeres in peripheral blood cells of individuals with BD compared to healthy controls (Lima et al, 2014;Rizzo et al, 2013), whereas other studies did not find shortened telomeres in BD compared to healthy volunteers (Mansour et al, 2011). Similarly, telomere lengths did not differ in the cerebellar gray matter of individuals with BD compared to controls (Zhang et al, 2010).…”

Section: Introductionmentioning

confidence: 88%

“…Studies enrolled BD participants in different mood states. For example, Rizzo et al (2013) included a sample of euthymic females with BD, whereas Lima et al (2014) studied a moderately depressed sample.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Is bipolar disorder associated with accelerating aging? A meta-analysis of telomere length studies

Colpo¹,

Leffa

Köhler

et al. 2015

Journal of Affective Disorders

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 88%

See 1 more Smart Citation

Is bipolar disorder associated with accelerating aging? A meta-analysis of telomere length studies

Colpo¹,

Leffa

Köhler

et al. 2015

Journal of Affective Disorders

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“…Likewise, patients with bipolar depression presented shorter telomeres. 15 These findings have not been replicated in other studies that showed no changes in telomere length (measured as the T/S ratio) in subjects with BD or schizophrenia. 16 Hoen et al 17 found that anxiety disorders were strongly associated with telomere shortening after 2 years of follow-up, while no prospective correlation was observed in patients with major depression.…”

Section: Introductionmentioning

confidence: 82%

“…20 Shorter telomere length in a sample of moderately depressed BD patients seemed not to be influenced by medication, although a decreased mean telomere length was observed in drug-free patients when Shortened telomeres in bipolar disorder compared to controls. 15 In contrast, Mansour et al 16 reported no difference in telomere length between BD patients and a healthy control group. Multiple mechanisms might be implicated in telomere shortening in BD, including oxidative stress 28 leading to secondary DNA damage, 29 inflammation, 30 and glucocorticoid load.…”

Section: Discussionmentioning

confidence: 98%

Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease

Barbé-Tuana

Parisi

Panizzutti

et al. 2016

Rev. Bras. Psiquiatr.

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Objective: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among participants with BD at early and late stages and age-and gender-matched healthy controls. Methods: Twenty-six euthymic subjects with BD and 34 healthy controls were recruited. Genomic DNA was extracted from peripheral blood and mean telomere length was measured using real-time quantitative polymerase chain reaction. Results: Telomere length was significantly shorter in both the early and late subgroups of BD subjects when compared to the respective controls (p = 0.002 and p = 0.005, respectively). The sample size prevented additional subgroup analyses, including potential effects of medication, smoking status, and lifestyle. Conclusion: This study is concordant with previous evidence of telomere shortening in BD, in both early and late stages of the disorder, and supports the notion of accelerated aging in BD.

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Telomere length as a predictor of emotional processing in the brain

Powell

Jong

Breen

et al. 2018

Human Brain Mapping

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Shorter telomere length (TL) has been associated with the development of mood disorders as well as abnormalities in brain morphology. However, so far, no studies have considered the role TL may have on brain function during tasks relevant to mood disorders. In this study, we examine the relationship between TL and functional brain activation and connectivity, while participants (n = 112) perform a functional magnetic resonance imaging (fMRI) facial affect recognition task. Additionally, because variation in TL has a substantial genetic component we calculated polygenic risk scores for TL to test if they predict face‐related functional brain activation. First, our results showed that TL was positively associated with increased activation in the amygdala and cuneus, as well as increased connectivity from posterior regions of the face network to the ventral prefrontal cortex. Second, polygenic risk scores for TL show a positive association with medial prefrontal cortex activation. The data support the view that TL and genetic loading for shorter telomeres, influence the function of brain regions known to be involved in emotional processing.

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Analysis of telomere attrition in bipolar disorder

Cited by 51 publications

References 38 publications

Is bipolar disorder associated with accelerating aging? A meta-analysis of telomere length studies

Is bipolar disorder associated with accelerating aging? A meta-analysis of telomere length studies

Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease

Telomere length as a predictor of emotional processing in the brain

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