2020
DOI: 10.1101/2020.06.04.134502
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Abstract: Children who grow up in socioeconomically disadvantaged families face increased burden of disease and disability as they mature into adulthood. One hypothesized mechanism for this increased burden is that early-life disadvantage and its associated psychological stress accelerate biological processes of aging, increasing vulnerability to subsequent disease. In order to evaluate this hypothesis and the potential impact of preventive interventions, measures to quantify the early acceleration of biological aging i… Show more

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Cited by 7 publications
(8 citation statements)
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“…Although this assumption is widespread in the literature, including for epigenetic clock analyses 50,51 , our results are broadly consistent with empirical results in humans. Specifically, while studies of early life adversity, which also predicts lifespan in human populations, find relatively consistent support for a relationship between early adversity and accelerated epigenetic aging in children and adolescents 12,13,[52][53][54][55][56] , there is little evidence for the long-term effects of early adversity on epigenetic age in adulthood 14,[57][58][59][60][61] . Thus, while DNA methylation may make an important contribution to the biological embedding of early adversity into adulthood 62,63 , it does not seem to do so through affecting the epigenetic clock itself.…”
Section: Discussionmentioning
confidence: 99%
“…Although this assumption is widespread in the literature, including for epigenetic clock analyses 50,51 , our results are broadly consistent with empirical results in humans. Specifically, while studies of early life adversity, which also predicts lifespan in human populations, find relatively consistent support for a relationship between early adversity and accelerated epigenetic aging in children and adolescents 12,13,[52][53][54][55][56] , there is little evidence for the long-term effects of early adversity on epigenetic age in adulthood 14,[57][58][59][60][61] . Thus, while DNA methylation may make an important contribution to the biological embedding of early adversity into adulthood 62,63 , it does not seem to do so through affecting the epigenetic clock itself.…”
Section: Discussionmentioning
confidence: 99%
“…Childhood socioeconomic disadvantage and epigenetic aging. Several studies have found that exposure to trauma or socioeconomic disadvantage in early life is associated with accelerated epigenetic aging, 10,41,47,49,50,55,57,59,70 particularly during critical periods of development. 55,70 The vast majority of these studies have assessed associations with first generation clocks.…”
Section: Associations Between Ses Dimensions and Epigenetic Clocksmentioning
confidence: 99%
“…41,49,55,56 However, several studies have found a null relationship between childhood SES and EAA as measured by first generation clocks. 53,[57][58][59] More recently, studies have begun to explore SES associations with second generation clocks trained on phenotypic biomarkers of aging. These studies have found more consistent associations between socioeconomic position and the Levine, GrimAge, and DunedinPoAm clocks, 9,10,48,[59][60][61][62] suggesting that these clocks may be capturing pathways of aging that are more proximal to social conditions.…”
Section: Introductionmentioning
confidence: 99%
“…41,49,55,56 However, several studies have found a null relationship between childhood SES and EAA as measured by first generation clocks. 53,[57][58][59] More recently, studies have begun to explore SES associations with second generation clocks trained on phenotypic biomarkers of aging. These studies have found more consistent associations between socioeconomic position and the Levine, GrimAge, and DunedinPoAm clocks, 9,10,48,[59][60][61][62] suggesting that these clocks may be capturing pathways of aging that are more proximal to social conditions.…”
Section: Introductionmentioning
confidence: 99%