Analysis of serum adenosine deaminase (ADA) and ADA1 and ADA2 isoenzyme activities in HIV positive and HIV–HBV co-infected patients

Khodadadi, Iraj; Abdi, Mohammad; Ahmadi, Abbas; Wahedi, Mohammad Saleh; Menbari, Shahoo; Lahoorpour, Fariba; Rahbari, Rezgar

doi:10.1016/j.clinbiochem.2011.05.020

Cited by 24 publications

(22 citation statements)

References 23 publications

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“…The increasing of serum tADA activity in co-infected patients was significantly greater than those of HIV mono-infected individuals. This observation is supported by our previous report confirming a greater rise in tADA activity in HIV-HBV co-infection compared with HIV monoinfection (10). Here, we confirmed that HIV-HCV coinfection can also enhances tADA activity greater than HIV monoinfection.…”

Section: Table 1 Personal Characteristics Activities Of Liver Enzymsupporting

confidence: 92%

Serum Adenosine Deaminase (ADA) Activity: A Novel Screening Test to Differentiate HIV Monoinfection From HIV‐HBV and HIV‐HCV Coinfections

Abdi

Rahbari

Khatooni

et al. 2015

Clinical Laboratory Analysis

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Section: Table 1 Personal Characteristics Activities Of Liver Enzymsupporting

confidence: 92%

Serum Adenosine Deaminase (ADA) Activity: A Novel Screening Test to Differentiate HIV Monoinfection From HIV‐HBV and HIV‐HCV Coinfections

Abdi

Rahbari

Khatooni

et al. 2015

Clinical Laboratory Analysis

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“…Changes in normal levels of ADA have been reported in a wide variety of pathologies . For example, alterations in the amount of one or both isoenzymes have been observed in a number of diseases such as hereditary hemolytic and Diamond Blackfan anemias, tuberculosis, systemic lupus erythematosus, inflammatory responses, rheumatoid arthritis, heart diseases, acquired immunodeficiency syndrome, autoimmunological thyroid diseases, some types of carcinoma, and neurological disorders, such as multiple sclerosis, meningitis, fibromyalgia, depression, and panic disorder …”

Section: Introductionmentioning

confidence: 99%

Moonlighting Adenosine Deaminase: A Target Protein for Drug Development

Cortés

Gracia

Moreno

et al. 2014

Medicinal Research Reviews

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Interest in adenosine deaminase (ADA) in the context of medicine has mainly focused on its enzymatic activity. This is justified by the importance of the reaction catalyzed by ADA not only for the intracellular purine metabolism, but also for the extracellular purine metabolism as well, because of its capacity as a regulator of the concentration of extracellular adenosine that is able to activate adenosine receptors (ARs). In recent years, other important roles have been described for ADA. One of these, with special relevance in immunology, is the capacity of ADA to act as a costimulator, promoting T-cell proliferation and differentiation mainly by interacting with the differentiation cluster CD26. Another role is the ability of ADA to act as an allosteric modulator of ARs. These receptors have very general physiological implications, particularly in the neurological system where they play an important role. Thus, ADA, being a single chain protein, performs more than one function, consistent with the definition of a moonlighting protein. Although ADA has never been associated with moonlighting proteins, here we consider ADA as an example of this family of multifunctional proteins. In this review, we discuss the different roles of ADA and their pathological implications. We propose a mechanism by which some of their moonlighting functions can be coordinated. We also suggest that drugs modulating ADA properties may act as modulators of the moonlighting functions of ADA, giving them additional potential medical interest.

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“…Adenosin deaminase wassignificantlylower in association with HIV infection; previous studies have well described the increased level of ADA in patients suffering from inflammatory processes,[32] infections,[33] immunodeficiency syndromes,[34] and AIDS. [35] Such an inverse correlation has been also detected in association with CD4+ cell count.…”

Section: Discussionmentioning

confidence: 99%

Comparison of adenosine deaminase, zinc, magnesium, lipid profile, and some micronutrient elements and their relation with CD4 counts in human immunodeficiency virus positive and negative patients

Abdollahi¹,

Shoar

2012

J Global Infect Dis

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Background:There is strong evidence regarding the patterns of alteration in the blood parameters in human immunodeficiency virus (HIV)-positive patients. However, no consensus has been reached in this regard and the results vary from different regions and studies. Our study aims to report these patterns in a population of HIV-infected patients in Iran.Materials and Methods:We studied two groups of HIV-infected and HIV-negative patients. One hundred and fourteen subjects were enrolled in each group; blood parameters were compared in these two.Results:Variables of HIV-negative patients changed as follows compared to HIV-positive patients: with regard to the hematological variables, CD4+↓; CD8+↓; WBC↓; RBC↓; HCT↓; MCV↑; MCH↑; MCHC↑; PLT↓; EOS↑; and BASO↑; and among the metabloic parameters, TG↓; CH↑; HDL↓; LDL↓, MG↑; ZN↑; P↑; and ADA↓, which showed significnat differences between groups (P < 0.05).Conclusion:We conclude that HIV infection affects hematopoiesis by diminishing the hematological productivity parameters and increasing red blood cell related morphology, along with a different pattern of lipid profile (decreased TG, LDL, HDL, and increased CH) and serum micronutrients (elevated concentration of serum trace elements) in our population of study.

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Analysis of serum adenosine deaminase (ADA) and ADA1 and ADA2 isoenzyme activities in HIV positive and HIV–HBV co-infected patients

Cited by 24 publications

References 23 publications

Serum Adenosine Deaminase (ADA) Activity: A Novel Screening Test to Differentiate HIV Monoinfection From HIV‐HBV and HIV‐HCV Coinfections

Serum Adenosine Deaminase (ADA) Activity: A Novel Screening Test to Differentiate HIV Monoinfection From HIV‐HBV and HIV‐HCV Coinfections

Moonlighting Adenosine Deaminase: A Target Protein for Drug Development

Comparison of adenosine deaminase, zinc, magnesium, lipid profile, and some micronutrient elements and their relation with CD4 counts in human immunodeficiency virus positive and negative patients

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