Analysis of Risk Factors in Psoriatic Patients With Methotrexate-Induced Increases in Transaminase Levels

Conventional Therapies for Psoriasis

“…It is important to ensure that a psoriasis "flare" is not due to an undiagnosed concomitant disease affecting immune response (3). In fact, no prospective, randomized, placebo controlled trials have ever been published, but an active controlled study which compares methotrexate with cyclosporine (4). In this study, methotrexate proved to be poorly tolerated in that about 1 / 4 of patients had to discontinue it because of elevation of transaminases.…”

Real-life experience of using conventional diseasemodifying anti-rheumatic drugs (DMARDs) in psoriatic arthritis (PsA). Retrospective analysis of the efficacy of methotrexate, sulfasalazine, and leflunomide in PsA...

“…In some cases a liver biopsy may be recommended (41). Male gender and increased age have also been found to be associated with an increased risk of increases in transaminases (42), whereas supplementation with folic acid reduces abnormalities in liver function with no effect on efficacy in RA (43). The same regime of folic acid is recommended for PsA.…”

Psoriatic arthritis: Current concepts on pathogenesis‐oriented therapeutic options

“…RA therapies such as methotrexate (MTX) may have not only differing efficacy in PsA, but also different toxicity patterns (53–56). The challenge with treatment of PsA comes with the diversity of the disease phenotypes as well as the degrees of severity of individual disease manifestations in both the skin and joints.…”