Analysis of prognostic factors associated with injection-site sarcomas in cats: 57 cases (2001–2007)

Romanelli, Giorgio; Marconato, Laura; Olivero, Daniela; Massari, Federico; Zini, Eric

doi:10.2460/javma.232.8.1193

Cited by 66 publications

(141 citation statements)

References 27 publications

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“…Fortunately, the situation in Poland is better than, for example, in the UK where the most affected site is still the interscapular region and the percentage of FISS arisen in this area of the body reaches 84% (Kass et al 2003). Although the size of the tumor did not influence the outcome of surgical treatment in one study it seems that smaller sarcomas much more often allow for complete resection (Romanelli et al 2008). The present study has revealed that medical diagnosis of FISS is commonly obtained in advanced stage, because in more than 35% of cases a diameter of the tumor was longer than 5 cm, and only 25% of tumors were considered to be small (diameter shorter than 2 cm).…”

Section: Discussionmentioning

confidence: 97%

“…However, we decided to compare histopathological picture of randomly selected cases of FISS with tumors growing in location that allow to excluded their connection with injections. In eariler studies microscopic features of vaccine-associated sarcomas rather than injection site sarcomas were usually described (Couto et al 2002, Gobar and Cass 2002, Romanelli et al 2008. Previous investigations have shown that the most common histological type of FISS is fibrosarcoma; it accounts for about 80-90% of these tumors (Couto et al 2002, Romanelli et al 2008, Giudice et al 2010, Wilcock et al 2012.…”

Section: Discussionmentioning

confidence: 99%

“…In eariler studies microscopic features of vaccine-associated sarcomas rather than injection site sarcomas were usually described (Couto et al 2002, Gobar and Cass 2002, Romanelli et al 2008. Previous investigations have shown that the most common histological type of FISS is fibrosarcoma; it accounts for about 80-90% of these tumors (Couto et al 2002, Romanelli et al 2008, Giudice et al 2010, Wilcock et al 2012. Our findings were similar -fibrosarcoma was the most common histopathological type (72% of FISS), followed by undifferentiated spindle-cell sarcomas, liposarcomas and other types which were recognized incidentally.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological and morphological analysis of feline injection site sarcomas

Kliczkowska¹,

Jankowska²,

Jagielski³

et al. 2015

Polish Journal of Veterinary Sciences

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Feline injection site sarcomas (FISS) are malignant neoplasms of mesenchymal origin which arise in sites of injections in cats. The prevalence is estimated between 1 in 1000 and 1 in 10 000 vaccinations in the United Kingdom. The aim of this study was to estimate the incidence of FISS in Poland and to analyse clinical aspects and histological and cytological features of injection site sarcomas. In our study the prevalence of FISS was 0.16% (16 FISS on 10.000 of cats) in feline patients in one of a veterinary surgery which conducts the general practice and 85 on 10.000 cats in a practice focused on veterinary oncology. The most typical microscopic features of FISS found in the present analysis were: the presence of perilesional scarring and inflammation, aggregates of lymphocytes at the tumour periphery, moderate but usually marked cellular pleomorphism and intralesional necrosis. The most typical cytologic features of FISS found in present study were: the presence of neutrophils, marked cellular pleomorphism, the presence of lymphocytes and macrophages, the presence of extremely large nuclei in the neoplastic cells, and high sample cellularity.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Epidemiological and morphological analysis of feline injection site sarcomas

Kliczkowska¹,

Jankowska²,

Jagielski³

et al. 2015

Polish Journal of Veterinary Sciences

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“…7,31 The decision of whether to use an adjunctive therapy is often based on histologic grading of the neoplasm. 7 The most widely used grading scale is that described by Kuntz et al for soft tissue sarcomas in dogs.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Expression of c-KIT Protein in Feline Soft Tissue Fibrosarcomas

2009

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Abstract. C-KIT is the cellular homolog of the feline sarcoma viral oncogene v-KIT, which encodes the tyrosine kinase receptor protein KIT. Mutations and varied expression of this gene have been demonstrated within multiple neoplasms in people and domestic animals. The purpose of this study was to determine if KIT protein is expressed in feline soft tissue fibrosarcomas (ST FSA) using immunohistochemistry (IHC). The computer database at the Oklahoma Animal Disease Diagnostic Laboratory was searched from January 1, 2006, to December 31, 2007, for any domestic cat with an ST FSA. Routinely stained slides from 46 feline ST FSAs were reviewed and graded based on the scale outlined by Kuntz et al. Immunohistochemistry for KIT protein was performed on one representative section from each cat. There were a total of 12/46 (26%) cats that were immunoreactive for KIT. Immunoreactivity was detected in greater than 80% of the neoplastic cells in 4/46 (9%) cats. Immunoreactivity was detected in less than 10% of the neoplastic cells in 8/46 (17%) cats. Immunoreactivity was characterized by evenly distributed cytoplasmic stippling within the neoplastic spindle-shaped cells and/or multinucleated giant cells. Based on these results, KIT immunoreactivity can be detected within feline ST FSAs using IHC. The results of this study also indicate that KIT immunoreactivity in feline ST FSA does not correlate with the histologic grade (P 5 .141, X 2 5 2.166), survivability (P 5 .241, X 2 5 1.373), or whether the neoplasm was a spontaneous or an injection site FSA (P 5 .074, X 2 5 3.184).

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“…The obtainment of clean surgical margins is considered important for predicting local recurrence of FISS (Kobayachi et al, 2002;Giudice et al, 2010). But there are reports of up to 50% recurrence rates in neoplasms excised with clear surgical margins (Romanelli et al, 2008;Phelps et al, 2011). This high recurrence rate can be explained by an asymmetrical dissemination of neoplastic cells, hindering accurate margin assessment (Giudice et al, 2010;Ehrhart & Powers, 2013).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of adjuvant chemotherapy in feline injection site-associated sarcoma

Pereira

Campos

Horta

et al. 2017

Arq. Bras. Med. Vet. Zootec.

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Feline Injection Site-Associated Sarcoma (FISS) is a neoplasm that implies in reduction of quality of life and overall survival in feline patients. A retrospective study of 13 cases of FISS was conducted to evaluate the efficacy of surgical treatment associated to chemotherapy with doxorubicin or carboplatin. Local recurrence occurred in all patients. Patients treated with surgery and chemotherapy presented a longer overall survival and disease-free interval when compared to those that solely received surgical treatment, although no statistical significance was observed (p= 0.3360 and 0.7506, respectively). Surgery remains as the main option for FISS treatment. Further prospective studies with larger samples are warranted to investigate the benefit of chemotherapy for this neoplasm.Keywords: FISS, Doxorubicin, Carboplatin, surgery RESUMO O Sarcoma de Aplicação Felino (SAF) é uma neoplasia associada a redução na qualidade de vida e sobrevida global. O objetivo deste estudo foi avaliar a eficácia da quimioterapia associada à cirurgia no manejo do SAF. Estudo retrospectivo de 13 pacientes com SAF submetidos à cirurgia isolada ou

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Analysis of prognostic factors associated with injection-site sarcomas in cats: 57 cases (2001–2007)

Cited by 66 publications

References 27 publications

Epidemiological and morphological analysis of feline injection site sarcomas

Epidemiological and morphological analysis of feline injection site sarcomas

Immunohistochemical Expression of c-KIT Protein in Feline Soft Tissue Fibrosarcomas

Evaluation of adjuvant chemotherapy in feline injection site-associated sarcoma

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