2020
DOI: 10.5137/1019-5149.jtn.29805-20.2
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Abstract: AIM:To investigate the effect of mitochondrial DNA (mtDNA) variants mainly in D-loop on glioma biology. MATERIAL and METHODS:Sanger sequencing of D-loop (15971-16451 bp) for 52 glioma patients was performed and the variations were statistically analyzed for gender, WHO classification, morphological grade, IDH/TERT status. RESULTS:Total of 122 variations (51 unique) were identified in 52 patients. C16223T, T16189C, T16311C and T16126C variants were frequently detected. The total variation number was statistical… Show more

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