Analysis of Metal Contents in Portland Type V and MTA-Based Cements

Dorileo, Maura Cristiane Gonçales Orçati; Bandéca, Matheus Coêlho; Pedro, Fábio Luís Miranda; Volpato, Luiz Evaristo Ricci; Guedes, Orlando Aguirre; Villa, Ricardo Dalla; Tonetto, Mateus Rodrigues; Borges, Álvaro Henrique

doi:10.1155/2014/983728

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…Several reports have been published regarding the heavy metal content of MTA cements ; however, limited studies have focused on the levels of Al in these dental biomaterials. Aluminium has diverse adverse health effects, including neurotoxicity , genotoxicity , Alzheimer's disease, dementia, hyperactivity, and learning disorders in children .…”

Section: Discussionmentioning

confidence: 99%

In vivo evaluation of the effects of hydraulic calcium silicate dental cements on plasma and liver aluminium levels in rats

Demirkaya

Demirdöğen

Torun

et al. 2015

European J Oral Sciences

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Our aim was to test whether the presence of three hydraulic calcium silicate dental cements--MTA Angelus, MTA Fillapex, and Theracal LC--in the dental extraction socket of an in vivo model, would affect the levels of aluminium (Al) in the plasma and liver. Following anesthesia, the right upper incisor of each male Wistar albino rat was extracted and polyethylene tubes filled with MTA Angelus, MTA Fillapex, or Theracal LC were inserted into the depth of the extraction socket and gingival tissue was sutured. The rats were killed 7, 30, or 60 d after the operation. Blood and liver samples were obtained from the rats before they were killed, and the levels of Al were measured by atomic absorption spectrometry. Plasma Al levels were higher in the rats in which the mineral trioxide aggregate (MTA) cements were implanted, especially MTA Angelus and MTA Fillapex, compared with control rats. In liver samples, however, the differences in Al level were not statistically significant. Our results show that Al might have been released into the circulation from the three dental cements tested, especially MTA Angelus and MTA Fillapex. Further research should be carried out on the possible biological effects of Al liberated from dental cements.

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Section: Discussionmentioning

confidence: 99%

In vivo evaluation of the effects of hydraulic calcium silicate dental cements on plasma and liver aluminium levels in rats

Demirkaya

Demirdöğen

Torun

et al. 2015

European J Oral Sciences

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“…Previous studies have attributed the discoloration effect of MTA to the presence of bismuth in its mixture ( 23 , 28 ). Since the amount of bismuth in the PC is much less than MTA ( 29 ), previous researches concluded that the rate of color change due to use of PC should be lower than MTA ( 14 , 30 ). However, in this study, the rate of color change due to the application of PC in all of the time periods was higher than other materials.…”

Section: Discussionmentioning

confidence: 99%

The Discoloration effect of White Mineral Trioxide Aggregate (WMTA), Calcium Enriched Mixture (CEM), and Portland Cement (PC) on Human Teeth

et al. 2017

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BackgroundThe aim of this study was to evaluate the discoloration induced by CEM cement, Portland cement (PC) and MTA mixed with propylene glycol (MTA-PG) in comparison to White MTA.Material and MethodsNinety extracted premolar and canine teeth were resected 2 mm below the CEJ. The coronal part of crown was prepared with peeso reamer and Gates-Glidden drills, and the specimens were randomly divided into 4 experimental (n=20) and one control (n=10) groups. The tooth crowns in experimental groups 1 to 4 were filled with White MTA, PC, CEM cement and MTA-PG, respectively; and in group 5, the teeth were kept empty. After incubation, digital photographs of teeth were acquired at 4 time points (before, immediately after placing the materials, 3 and 6 months afterwards). Images were transferred to Adobe Photoshop CS4 and CIE L*a*b color space was used for tooth shade assessment. One-Way ANOVA and One-Sample t-test were used to compare discoloration of teeth between groups.ResultsSignificant statistical discoloration was only observed in the cervical one third of all groups at each time points (except between 3 and 6 months). Tooth discoloration was greatest in PC and lower in MTA and MTA-PG at the end of 6 months. The tooth discoloration between immediately and 3 months after placing the materials had significant difference only between MTA and PC; and also the tooth discoloration between immediately and 6 months after placing the materials was observed only between PC and MTA, and PC and MTA-PG.ConclusionsAll of the experimental biomaterials caused tooth discoloration after 6 months, of those, PC had the most and MTA and MTA-PG had the least discoloration effect. Key words:Mineral trioxide aggregate (MTA). Calcium enriched mixture (CEM). Propylene glycol. Portland cement.

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“…The most common form of As is the inorganic type which comes either as trivalent (III) or pentavalent (V) ( 10 ). Various studies have confirmed the presence of As in MTA and MTA-like cements ( 2 - 4 , 7 , 11 - 16 ). The chemical analysis of dental cements concerning As amount showed equivocal results.…”

Section: Introductionmentioning

confidence: 94%

“…It is also advocated for use as a pulp-capping material due to its biocompatibility and sealing ability ( 1 ). MTA is mainly composed of tricalcium silicate, tricalcium aluminate and tetracalcium aluminoferrite which come from its Portland cement component, in addition to bismuth oxide to give the cement its radiopacity ( 2 , 3 ). Portland cement, the main component of MTA ( 4 ), is a hydraulic material.…”

Section: Introductionmentioning

confidence: 99%

In vitro Mitigation of Arsenic-induced Toxicity by Reduced Glutathione in Rat Pulpal Cells

et al. 2020

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Objective: Despite the controversial results regarding the amount of arsenic (As) in mineral trioxide aggregate (MTA) and MTA-like cements, it is prudent to assess the effect of this heavy metal on pulpal cells and search for methods to attenuate its toxicity. This study investigated the toxic effect of As on pulpal-like cells and evaluated the influence of reduced glutathione (GSH) on As-induced toxicity. Methods: The cytotoxicity of 50 µm As, 50 µm As+50 µM GSH, 50µm As+500 µM GSH or 50 µm As+5000 µM GSH on rat pulpal cells (RPC-C2A) was evaluated at 24 hours and 72 hours. Cell culture in fresh medium without experimental solution served as the control. Cell viability was measured by means of 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay and the optical density was measured with microplate reader. The morphology of the cultured cells was observed under phase contrast microscope. Cytotoxicity data were analyzed by two-way ANOVA and Tukey post hoc tests (P<0.05). Results: There were statistically significant differences in cell viability amongst the tested groups (P<0.05). As elicited remarkable toxic effect on pulpal cells, while 5000 µM GSH protected the cells from As-induced damage at 24-hour exposure time. The cultured control cells were polygonal-shaped; however, As-treated cells exhibited contracted and spherical morphology with increased intercellular spaces indicative of cellular death and decreased proliferation. Conclusion: As negatively affected the viability of pulpal cells; however, controlled concentration of GSH had a short-term protective effect against As-induced toxicity. Future research is warranted on the clinical use of GSH with MTA and MTA-like cements to minimize initial inflammation resulting from As release during the setting of the aforementioned cements thus enhancing the success of procedures where these cements are placed in direct contact with vital pulp tissues.

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Analysis of Metal Contents in Portland Type V and MTA-Based Cements

Cited by 10 publications

References 22 publications

In vivo evaluation of the effects of hydraulic calcium silicate dental cements on plasma and liver aluminium levels in rats

In vivo evaluation of the effects of hydraulic calcium silicate dental cements on plasma and liver aluminium levels in rats

The Discoloration effect of White Mineral Trioxide Aggregate (WMTA), Calcium Enriched Mixture (CEM), and Portland Cement (PC) on Human Teeth

In vitro Mitigation of Arsenic-induced Toxicity by Reduced Glutathione in Rat Pulpal Cells

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