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Cited by 9 publications
(3 citation statements)
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References 62 publications
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“…For mast cells, it was not hard to explain the decrease of mast cells resting as the mast cells were activated in face of sepsis. The relationship of mast cells with hypertension, the remolding of collagen fibers (Juliano et al, 2020), and cardiac fibrosis (Kong et al, 2014) had been confirmed, but the function of mastocytes in the pathological process of SIC still required complemented research studies for further elaboration.…”
Section: Discussionmentioning
confidence: 99%
“…For mast cells, it was not hard to explain the decrease of mast cells resting as the mast cells were activated in face of sepsis. The relationship of mast cells with hypertension, the remolding of collagen fibers (Juliano et al, 2020), and cardiac fibrosis (Kong et al, 2014) had been confirmed, but the function of mastocytes in the pathological process of SIC still required complemented research studies for further elaboration.…”
Section: Discussionmentioning
confidence: 99%
“…of uninfected heart tissue reported no significant relationship between mast cells and collagen content in human atria [18,50]. Recent work, using a group of 30 patients, showed a positive correlation between mast cell density as assessed by protease immunohistochemistry and collagen content in post mortem samples of the left ventricle of patients with hypertensive heart disease [52]. However, time from death to tissue excision is not noted, despite its importance to interpretation [51].…”
Section: Discussionmentioning
confidence: 99%
“…Chymase may be involved in the pathogenesis of cardiac fibrosis via the formation of angiotensin II and TGF-β. In autopsied patients with hypertensive heart diseases, chymase-positive mast cell numbers in the heart were significantly higher than in those without heart diseases, and a significant positive correlation between chymase-positive mast cell numbers and collagen fibers was found [ 29 ]. In canine heart failure induced by rapid right ventricular pacing, the number of chymase-positive mast cells increased in the left ventricle compared with the normal group; however, a chymase inhibitor significantly decreased chymase-positive mast cell density, cardiac angiotensin II concentration, mRNA levels of TGF-β, collagen I, and collagen III, and cardiac fibrosis [ 30 ].…”
Section: Cardiovascular Diseasesmentioning
confidence: 99%