Analysis of influenza B virus lineages and the HA1 domain of its hemagglutinin gene in Guangzhou, southern China, during 2016

Feng, Ye; Chen, Xiaojuan; Guan, Weijun; Pan, Sihua; Yang, Zifeng; Chen, Rongchang

doi:10.1186/s12985-018-1085-5

Cited by 4 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This curious difference could involve the effect known as “Original Antigenic Sin” or “OAS.” 35–37 This show that the first influenza infections determine how those that occur in the rest of life, responding better to viruses similar to the first encounter. In our particular case, we believe that the ancestral B type strain B/Lee/40, which circulated until 1983 and then split into the two lineages we currently know, 38 may be partly related to this effect. Although both lineages emerged at the same time, the B/Victoria lineage circulated more intense during the next two decades, 39 , 40 whereas the B/Yamagata lineage prevailed during the 1990s.…”

Section: Discussionmentioning

confidence: 80%

Long-term influenza antibodies profiles in previously vaccinated and non-vaccinated adults

Sanz-Muñoz,

Lajara,

Sánchez-Martínez

et al. 2023

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

The aim of this work is to describe the dynamics of influenza antibodies after vaccination in adults. We conducted a case-cohort serological study in the automobile manufacturing plants of the Renault España S.A. group in Valladolid and Palencia (Spain), including 550 workers (66.9%) previously vaccinated against influenza (group V), and 272 (33.1%) never vaccinated (group NV). A pre-vaccination serum sample was collected, another after 30–40 days and another after 6 months. The dynamics of antibodies were analyzed. A lower seroprotection of NV before vaccination was observed, but an antibody response between 2 and 4 times higher than in V was assessed. After 6 months, antibodies declined in both groups until equalize. Antibodies titers decrease with age, and no differences were found among underlying pathologies. Adults never vaccinated against influenza had lower seroprotection than those previously vaccinated, but influenza vaccination produces a more intense serological response in them, acquiring significantly higher antibody titers than those previously vaccinated. The antibodies, although in lower titers, persist and equalize among both groups at least 6 months after vaccination, which allows the individual to be protected during the entire circulation of the influenza virus in the same season.

show abstract

Section: Discussionmentioning

confidence: 80%

Long-term influenza antibodies profiles in previously vaccinated and non-vaccinated adults

Sanz-Muñoz,

Lajara,

Sánchez-Martínez

et al. 2023

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

show abstract

“…During early 1980s, it evolved into two lineages, designated as B/Yamagata (B/Y) and B/Victoria (B/V), showing distinct antigenicity and transmission pattern (Chen and Holmes, 2008 ; Kanegae et al 1990 ; Vijaykrishna et al 2015 ). Since then, Flu B viruses have co-circulated with Flu A virus during epidemic season and the dominant lineage has changed over years in different geographical locations (Ye et al 2018 ; Yang et al 2018 ). Several studies have pointed out the differences of the epidemiology between B/Y and B/V lineages, such as younger average ages of persons could be more easily attacked by higher transmissibility of B/V viruses, compared with B/Y viruses (Vijaykrishna et al 2015 ; Caini et al 2019 ; Yoshihara et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Increasing serum antibodies against type B influenza virus in 2017–2018 winter in Beijing, China

Yao

Zhu

et al. 2022

AMB Expr

View full text Add to dashboard Cite

Influenza B virus circulates yearly with lower activity than that of influenza A virus in China. During winter 2017 to 2018, a sharp surge of influenza activity dominated by type B/Yamagata lineage virus caused unprecedented medical burden in Beijing. This research aimed to understand the underlying mechanism for this circulation and prepare for epidemics in the future. Sera samples collected from the patients in 2016–2017 and 2017–2018 flu seasons were tested for profiling hemagglutinin inhibition (HI) antibodies against both prevailing Victoria and Yamagata lineages of type B influenza viruses. It showed that the seroprevalence against both lineages of the virus in 2017–2018 winter was higher than that in 2016–2017, while no difference of the seroprevalence was observed between the two viruses. Meanwhile, significant elevated geometric mean titer (GMT) against both lineages of influenza B viruses was found in the specimens collected during 2017–2018 flu season than that from 2016 to 2017, suggesting the viruses might undergo antigenic changes. These results also suggested that lower GMT against both type B variants in 2016–2017 might serve as an immunological niche for the dominating of B/Yamagata virus in China during 2017–2018 winter season. Our findings have implication that there was a significantly elevation of HI antibodies to influenza viruses B in 2017–2018 than in 2016–2017. On the other hand, the low level of HI antibodies to both B/Y and B/V in 2016–2017 could contribute to the severe B/Y epidemic in 2017–2018 to some extent.

show abstract

“…During early 1980s, it evolved into two lineages, designated as B/Yamagata (B/Y) and B/Victoria (B/V), showing distinct antigenicity and transmission pattern (Chen R et al 2008;Kanegae et al 1990;Vijaykrishna et al 2015). Since then, Flu B viruses have co-circulated with Flu A virus during epidemic season and the dominant lineage has changed over years in different geographical locations (Ye et al 2018;Yang et al 2018). Several studies have pointed out the differences of the epidemiology between B/Y and B/V lineages, such as younger average ages of persons preferred being attacked by and higher transmissibility of B/V viruses, compared with B/Y viruses (Vijaykrishna et al 2015;Caini et al 2019;Yoshihara et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Increasing Hemagglutination Inhibition Antibodies against Two Lineages of Type B Influenza Virus in 2017-2018 Winter Season in Beijing, China

Yao¹,

Zhu²,

Li³

et al. 2020

Preprint

View full text Add to dashboard Cite

Influenza virus circulates every year with lower activity than that of influenza A virus in China. During 2017 to 2018 winter season, a sharp surge of influenza activity dominated by type B/Yamagata lineage virus caused unprecedented medical burden in Beijing. The research aimed to understand the underlying mechanism for this circulation and be prepared for epidemics in the future. Sera samples collected from the patients in 2016-2017 and 2017-2018 flu seasons were tested for profiling hemagglutinin inhibition (HI) antibodies against both prevailing Victoria and Yamagata lineages of type B influenza viruses. It showed that the seroprevalence against both lineages of the virus in 2017-2018 winter was higher than that in 2016-2017, while no difference of the seroprevalence was observed between the two viruses. Meanwhile, significant elevated geometric mean titer (GMT) against both lineages of influenza B viruses was found in the specimens collected during 2017-2018 flu season than that from 2016-2017, suggesting the viruses might undergo antigenic changes. These results also suggested that lower GMT against both type B variants in 2016-2017 might serve as an immunological niche for the dominating of B/Yamagata virus in China during 2017-2018 winter season. Our findings have implication that there was a significantly elevation of HI antibodies to influenza viruses B in 2017-2018, compared in 2016-2017. On the other hand, the low level of HI antibodies to both B/Y and B/V in 2016-2017 could contribute to the severe B/Y epidemic in 2017-2018 to some extent.

show abstract

Analysis of influenza B virus lineages and the HA1 domain of its hemagglutinin gene in Guangzhou, southern China, during 2016

Cited by 4 publications

References 25 publications

Long-term influenza antibodies profiles in previously vaccinated and non-vaccinated adults

Long-term influenza antibodies profiles in previously vaccinated and non-vaccinated adults

Increasing serum antibodies against type B influenza virus in 2017–2018 winter in Beijing, China

Increasing Hemagglutination Inhibition Antibodies against Two Lineages of Type B Influenza Virus in 2017-2018 Winter Season in Beijing, China

Contact Info

Product

Resources

About