Kinyui Alice Lo, Adam Labadorf, Norman J. Kennedy, Myoung Sook Han, Yoon Sing Yap, Bryan Matthews, Xiaofeng Xin, Lei Sun, Roger J. Davis, Harvey F. Lodish, Ernest Fraenkel
Diet-induced obesity predisposes individuals to insulin resistance, and adipose tissue has a major role in the disease. Insulin resistance can be induced in cultured adipocytes by a variety of treatments, but it is unknown what aspects of the in vivo responses are captured by these models. We use global RNA-sequencing (RNA-Seq) to investigate changes induced by TNFα, hypoxia, dexamethasone, high insulin, and a combination of TNFα and hypoxia, comparing the results to the changes in white adipose tissue from d…
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