Analysis of human papillomavirus infection and leukaemic infiltrate in cutaneous squamous cell carcinoma from patients with chronic lymphocytic leukaemia

Purcell, Rachel; Hock, Barry D.; Gardner, Jacqui; Goddard, Liping; MacPherson, Sean A.; McKenzie, Judith L.

doi:10.1111/bjh.15907

Cited by 3 publications

(19 citation statements)

References 11 publications

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“…1). 16–25,27–29,33–36,39,41–43,45–48,50–53,58–61,63–66,68,69 Moreover, to calculate the prevalence of cSCC after CLL diagnosis, we excluded case reports and case series in order to avoid overestimation and 16 articles including 612/19,015 patients developing cSCC after CLL diagnosis were finally considered 18,27,42,43,45,51–53,58,60,61,63–66,68 . The prevalence of cSCC after CLL diagnosis was 3.2%, and the average number of cSCC per patient was 2.3.…”

Section: Resultsmentioning

confidence: 99%

“…Forty-two articles [16][17][18][19][20][21][22][23][24][25][27][28][29][33][34][35][36]39,[41][42][43][44][45][46][47][48][50][51][52][53]55,[58][59][60][61][62][63][64][65][66]68,69 reported cases of cSCC developed after the diagnosis of CLL, nine studies 17,31,32,38,40,49,56,67,70 described the simultaneous diagnosis of both diseases, and 10 papers 1...…”

Section: Literature Searchmentioning

confidence: 99%

“…Forty-two articles, including 38807 patients affected by CLL, reported subsequent onset of cSCC. [16][17][18][19][20][21][22][23][24][25][27][28][29][33][34][35][36]39,[41][42][43][44][45][46][47][48][50][51][52][53]55,[58][59][60][61][62][63][64][65][66]68,69 To calculate the prevalence of cSCC in this population, we 3) (Fig. 1).…”

Section: Cll As the First Diagnosismentioning

confidence: 99%

“…[16][17][18][19][20][21][22][23][24][25][27][28][29][33][34][35][36]39,[41][42][43][45][46][47][48][50][51][52][53][58][59][60][61][63][64][65][66]68,69 Moreover, to calculate the prevalence of cSCC after CLL diagnosis, we excluded case reports and case series in order to avoid overestimation and 16 articles including 612/19,015 patients developing cSCC after CLL diagnosis were finally considered. 18,27,42,43,45,[51][52][53]58,60,61,…”

Section: Cll As the First Diagnosismentioning

confidence: 99%

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Cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia: a systematic review of the literature

et al. 2021

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The continuous improvement of life expectancy of patients with chronic lymphocytic leukemia (CLL) has resulted in increased risk of second primary malignancy that potentially may affect survival and quality of life of CLL patients. We performed a systematic review to assess the risk and the clinical‐pathological features and prognosis of cutaneous squamous cell carcinoma (cSCC) in patients with CLL. We searched PubMed, Embase, and Cochrane Central Register of Control Trials databases for articles published from database inception to December 31, 2019. English‐language studies reporting original data on patients with a specific diagnosis of CLL and cSCC were included. Data were extracted using a standardized extraction form, and any discordance was resolved by consensus. Descriptive data were generated by pooling patients from eligible studies. Of the 4588 non‐duplicate records identified, 55 articles met our inclusion criteria. These studies reported that CLL patients have a 3.2% prevalence of cSCC, with an 11.5% cSCC‐related lethality and an overall risk of metastasis of 5.7% (7.3% for regional lymph node involvement and 3.8% for distant metastasis). The quality of evidence was limited by the high heterogeneity in the design, populations, and objectives of the included studies. This systematic review suggests that cSCC in CLL patients tends to behave less aggressively compared with the solid organ transplant recipients but has a higher morbidity and mortality than in the general population. Future prospective studies are needed to increase the quality of evidence and to determine the best treatment modalities and screening intervals for these patients.

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Section: Resultsmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

Section: Cll As the First Diagnosismentioning

confidence: 99%

Section: Cll As the First Diagnosismentioning

confidence: 99%

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Cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia: a systematic review of the literature

et al. 2021

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“…Lymphocytic infiltrates have been previously described in the cSCC of CLL patients [ 21 ]. In our cohort, 60% of the lesions had moderate to high lymphocytic infiltration, a higher frequency than what is reported in the literature [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

The contribution of human papilloma virus infection to cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia

Bhavsar‐Bhakta

Hamza

Mehravaran

et al. 2021

eJHaem

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Patients with chronic lymphocytic leukemia (CLL), a B-cell malignancy characterized by impaired humoral and cellular immunity, are at increased risk of developing cutaneous squamous cell carcinoma (cSCC). Human papilloma virus (HPV) is the most common sexually transmitted infection worldwide and it has been associated with various malignancies, including cSCC. Impaired cell-mediated immunity is considered a primary risk factor in HPV-induced cSCC. We examined cSCC lesions from CLL patients with consensus review and HPV genetic analysis to further characterize the relationship between HPV and prevalence of cutaneous malignancy in this population. Eleven patients with CLL contributed 35 cSCCs. Treatment with chemotherapy shortened the latency time to first cSCC. HPV was detected in 54% of the lesions. Among the HPVpositive cSCC lesions, 84% of the lesions contained alpha-genus HPV, 42% contained beta-genus HPV, and 26% of the lesions contained both genera. There was a significant association between HPV-containing lesions and peritumoral lymphocytic inflammation, suggesting this as a future area for further characterization. The majority of the lesions, including those with alpha-genus HPV, occurred in sun-exposed areas, such as the scalp and face. These findings may lead to practice-changing recommendations for skin cancer, including the use of vaccinations to reduce HPV-associated skin cancer. K E Y W O R D S chronic lymphocytic leukemia (CLL), cutaneous squamous cell carcinoma, human papilloma virus (HPV) How to cite this article: Bhavsar-Bhakta P, Hamza M, Mehravaran S, et al. The contribution of human papilloma virus infection to cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia. eJHaem. 2021;2:228-235.

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Cutaneous malignancies in chronic lymphocytic leukemia

Zilberg,

Ferguson,

Lyons

et al. 2024

The Journal of Dermatology

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Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy that is associated with an increased risk of developing cutaneous malignancies. Clinical outcomes for these malignancies, including melanoma and keratinocyte cancers (KC), are worse for patients with CLL. Individuals with CLL develop an immunodeficiency of both the adaptive and innate immune system, which plays a role in the increased prevalence of skin cancers. This review focuses on the complex interplay between genetics, immunity, and pathogens that influence the cellular composition and biology of skin tumors and their microenvironment in CLL patients, and in comparison with other chronic hematological malignancies. It is paramount for dermatologists to be aware of the association between CLL (and chronic hematological malignancies more broadly) and cutaneous malignancies. This is a high‐risk population who require regular and vigorous dermatologic follow‐up.

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Analysis of human papillomavirus infection and leukaemic infiltrate in cutaneous squamous cell carcinoma from patients with chronic lymphocytic leukaemia

Cited by 3 publications

References 11 publications

Cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia: a systematic review of the literature

Cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia: a systematic review of the literature

The contribution of human papilloma virus infection to cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia

Cutaneous malignancies in chronic lymphocytic leukemia

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