Analysis of haloacetic acid mixtures by HPLC using an electrochemical detector coated with a surfactant-nafion film

Carrero, Hermes; Rusling, James F.

doi:10.1016/s0039-9140(98)00295-1

Cited by 33 publications

(22 citation statements)

References 17 publications

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“…Individuals living in urban areas were found to have higher levels of TCA than those living in rural areas. Carrero and Rusling (1999) also used reversed-phase chromatography for the analysis of HAAs in drinking water by HPLC. The authors used an Alltech Econosphere C 18 column and an electrochemical detector.…”

Section: High-performance Liquid Chromatographymentioning

confidence: 99%

“…As a result, no methods for the extraction of TCE by SPE were found. Several methods do exist, however, for the analysis of HAAs in water (Benanou et al, 1998;Martínez et al, 1998aMartínez et al, ,b, 1999Loos and Barcelo, 2001;Carrero and Rusling, 1999;Sarzanini et al, 1999) and urine (Kuklenyik et al, 2002;Calafat et al, 2003) using SPE.…”

Section: Solid-phase Extractionmentioning

confidence: 99%

See 1 more Smart Citation

A review of analytical methods for the determination of trichloroethylene and its major metabolites chloral hydrate, trichloroacetic acid and dichloroacetic acid

Delinsky

Bruckner

Bartlett

2005

Biomedical Chromatography

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Trichloroethylene (TCE) and some of its metabolites are potentially carcinogenic compounds that the general population is commonly exposed to in drinking water. Concentrations of TCE, dichloroacetic acid (DCA) and trichloroacetic acid (TCA) given to laboratory animals in cancer bioassays are high, whereas drinking water levels of the compounds are very low. It is not clear whether the trace amounts of TCE, DCA and TCA in drinking water pose a cancer risk to humans. The accuracy of pharmacokinetic studies relies on the analytical method from which blood and tissue concentration data are obtained. Models that extrapolate cancer risks of TCE and its metabolites from laboratory animals to humans, in turn, rely on the results of pharmacokinetic studies. Therefore, it is essential to have reliable analytical methods for the analysis of TCE and its metabolites. This paper reviews the methods currently in the literature for the analysis of TCE, DCA, TCA and, to a lesser extent, chloral hydrate (CH). Additional aspects of analytical methods such as method validation, species preservation and future directions in the analysis of TCE and its metabolites are also discussed.

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Section: High-performance Liquid Chromatographymentioning

confidence: 99%

Section: Solid-phase Extractionmentioning

confidence: 99%

A review of analytical methods for the determination of trichloroethylene and its major metabolites chloral hydrate, trichloroacetic acid and dichloroacetic acid

Delinsky

Bruckner

Bartlett

2005

Biomedical Chromatography

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“…Other analytical methods are gas chromatography with electron-capture detection (GC-ECD), 6-8 gas chromatographymass spectrometry (GC-MS), [9][10][11] high-performance liquid chromatography (HPLC), 12,13 liquid chromatography-mass spectrometry (LC-MS), [14][15][16] capillary electrophoresis (CE), 17 etc. For GC, CAAs must be extracted from drinking water, which requires a derivatization step.…”

Section: Introductionmentioning

confidence: 99%

Determination of Chloroacetic Acids in Drinking Water Using Suppressed Ion Chromatography with Solid-Phase Extraction

2009

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Suppressed ion chromatography with a conductivity detector was developed for the determination of trace amounts of underivatized chloroacetic acids (CAAs). When sodium carbonate and methanol were used as a mobile phase, the simultaneous determination of each CAA took approximately 25 min. The linearity, reproducibility and detection limits were determined for the proposed method. For the solid-phase extraction step, the effects of the pH of the sample solution, sample volume and the eluting agent were tested. Under the optimized extracting conditions, the average recoveries for CAAs spiked in tap water were 83 -107%, with an optimal preconcentration factor of 20. The reproducibility of recovery rate for CAAs was 1.2 -3.8%, based upon 6 repetitions of the recovery experiments.

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“…However, these methods have the disadvantages of needing the use concentrated acid and the performance of multiple solvent extractions to achieve a reasonable extraction recovery. Other methods have been reported including ion chromatography [9], headspace gas chromatography [10], high-pressure and liquid chromatography [11]. These methods also have some drawbacks, such as lack of selectivity, time-consuming and lack of stability.…”

Section: Introductionmentioning

confidence: 99%

Amperometric Sensor for Trichloroacetic Acid Based on Myoglobin/Colloidal Gold Nanoparticles Immobilized in Titania Sol–Gel Matrix

Yang

Bai

et al. 2006

Electroanalysis

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A new amperometric sensor for the determination of trichloroacetic acid (TCA) was developed based on the immobilization of myoglobin/colloidal gold nanoparticles in titania sol -gel matrix. The sensor showed a pair of welldefined and nearly reversible cyclic voltammetric peaks for the Mb Fe(III)/Fe(II) with a formal potential (E8') of À 335 mV and a peak-to-peak separation was 61 mV vs. Ag/AgCl (3.0 M KCl) at 100 mV s À1 in 0.1 M pH 7.0 phosphate buffer solutions (PBS). The formal potential of the Mb Fe(III)/Fe(II) couple shifted linearly with the pH with a slope of À 51.3 mV/pH, indicating that an electron transfer accompanies single-proton transportation. The sensor displayed a good electrocatalytic response toward the reduction of TCA and the catalytic mechanism was also discussed. The overpotential for the reduction of TCA was lowered by at least 0.8 V compared with that obtained at bare glassy carbon electrode. The linear range spans the concentration of TCA from 2.0 Â 10 À6 to1.2 Â 10 À5 M and the detection limit was 1.2 Â 10 À7 M. In addition, the stability, repeatability and selectivity of the sensor were also evaluated.

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Analysis of haloacetic acid mixtures by HPLC using an electrochemical detector coated with a surfactant-nafion film

Cited by 33 publications

References 17 publications

A review of analytical methods for the determination of trichloroethylene and its major metabolites chloral hydrate, trichloroacetic acid and dichloroacetic acid

A review of analytical methods for the determination of trichloroethylene and its major metabolites chloral hydrate, trichloroacetic acid and dichloroacetic acid

Determination of Chloroacetic Acids in Drinking Water Using Suppressed Ion Chromatography with Solid-Phase Extraction

Amperometric Sensor for Trichloroacetic Acid Based on Myoglobin/Colloidal Gold Nanoparticles Immobilized in Titania Sol–Gel Matrix

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