Analysis of factors affecting the decrease of endothelial cell density of imported donor corneas

Abstract

Purpose To evaluate the difference between corneal endothelial cell density at the moment of preservation and keratoplasty in imported donor corneas, and analyze the correlated factors of the difference. Methods Eighty‐seven corneas imported between March 2009 and February 2011 were evaluated. Corneal endothelial cell density at the moment of preservation was obtained from the medical record and was measured just before the keratoplasty. Results All of the corneas showed decrease of endothelial cell density. Mean endothelial cell density of imported donor corneas at the moment of preservation and keratoplasty was 2789±235 cells/mm2 and 2592±254 cells/mm2(p=<0.001). Mean endothelial cell loss was 197±148 cells/mm2, which was significantly correlated with preservation to surgery time, death to surgery time and preservation period more than 7 days(p=0.042, p=0.045, p=0.036 respectively). Conclusion Decrease of death to surgery time and keratoplasty before 7days of preservation period are needed for better surgical outcome.