Analysis of drug residues in tissue by combined supercritical-fluid extraction-supercritical-fluid chromatography-mass spectrometry-mass spectrometry

Super-Critical Fluid: An Overview on Analytical Applications

“…Various veterinary drugs such as dimenthoprim, hexestrol, diethylstilbestrol, and dienestrol were extracted and identified from the freeze-dried pig's kidney using the online SFE-SFC MS-MS system [150]. The Supercritical Freon-22 having higher extraction efficiency found significantly great extraction with steroid standards [estrone, testosterone, estriol, 17, amethylteste, 17, amethylteste] [151].…”

“…Utilizing a component online system of SFE-SFC-MS/MS system for various veterinary drugs including dimenthoprim, hexestrol, diethylstilbestrol, and dienestrol were extracted and were obtained or detected in the freezedried kidney pig's kidney [150]. Hence the efficiency obtained utilizing the instrument freon-22 is significant than that of SFC [151].…”

Super-Critical Fluid: An Overview on Analytical Applications

“…Various veterinary drugs such as dimenthoprim, hexestrol, diethylstilbestrol, and dienestrol were extracted and identified from the freeze-dried pig's kidney using the online SFE-SFC MS-MS system [150]. The Supercritical Freon-22 having higher extraction efficiency found significantly great extraction with steroid standards [estrone, testosterone, estriol, 17, amethylteste, 17, amethylteste] [151].…”

“…Utilizing a component online system of SFE-SFC-MS/MS system for various veterinary drugs including dimenthoprim, hexestrol, diethylstilbestrol, and dienestrol were extracted and were obtained or detected in the freezedried kidney pig's kidney [150]. Hence the efficiency obtained utilizing the instrument freon-22 is significant than that of SFC [151].…”

Supercritical Fluid Extraction of Sulphamethazine and its Metabolites from Meat Tissues

“…Quantitative (ppm) investigations involving supercritical fluids include the extraction of sulphonamides from animal tissues (1)(2)(3), whole milk (4), and an aqueous drug formulation (5). A number of studies have shown that the more polar sulphonamides were more difficult to extract and required more rigorous conditions, such as higher methanol modifier concentrations (3) in the bulk carbon dioxide extracting fluid or higher working pressures.…”

Capillary electrophoresis separation of sulphonamides and dihydrofolate reductase inhibitors

“…Alcoholmodified supercritical C 0 2 has been used to elute SFA from silica [4], ODS and cyan0 [5], amino [6] bonded and unspecified [7] packed columns with varying degrees of success. The best of these [7] has demonstrated the isocratic, isobaric and isothermal baseline resolution of six SFA.…”

Super-Critical Fluid: An Overview on Analytical Applications

“…Various veterinary drugs such as dimenthoprim, hexestrol, diethylstilbestrol, and dienestrol were extracted and identified from the freeze-dried pig's kidney using the online SFE-SFC MS-MS system [150]. The Supercritical Freon-22 having higher extraction efficiency found significantly great extraction with steroid standards [estrone, testosterone, estriol, 17, amethylteste, 17, amethylteste] [151].…”

“…Utilizing a component online system of SFE-SFC-MS/MS system for various veterinary drugs including dimenthoprim, hexestrol, diethylstilbestrol, and dienestrol were extracted and were obtained or detected in the freezedried kidney pig's kidney [150]. Hence the efficiency obtained utilizing the instrument freon-22 is significant than that of SFC [151].…”

Supercritical Fluid Extraction of Sulphamethazine and its Metabolites from Meat Tissues

“…Quantitative (ppm) investigations involving supercritical fluids include the extraction of sulphonamides from animal tissues (1)(2)(3), whole milk (4), and an aqueous drug formulation (5). A number of studies have shown that the more polar sulphonamides were more difficult to extract and required more rigorous conditions, such as higher methanol modifier concentrations (3) in the bulk carbon dioxide extracting fluid or higher working pressures.…”

Capillary electrophoresis separation of sulphonamides and dihydrofolate reductase inhibitors

“…Alcoholmodified supercritical C 0 2 has been used to elute SFA from silica [4], ODS and cyan0 [5], amino [6] bonded and unspecified [7] packed columns with varying degrees of success. The best of these [7] has demonstrated the isocratic, isobaric and isothermal baseline resolution of six SFA.…”

Super-Critical Fluid: An Overview on Analytical Applications

“…Various veterinary drugs such as dimenthoprim, hexestrol, diethylstilbestrol, and dienestrol were extracted and identified from the freeze-dried pig's kidney using the online SFE-SFC MS-MS system [150]. The Supercritical Freon-22 having higher extraction efficiency found significantly great extraction with steroid standards [estrone, testosterone, estriol, 17, amethylteste, 17, amethylteste] [151].…”

“…Utilizing a component online system of SFE-SFC-MS/MS system for various veterinary drugs including dimenthoprim, hexestrol, diethylstilbestrol, and dienestrol were extracted and were obtained or detected in the freezedried kidney pig's kidney [150]. Hence the efficiency obtained utilizing the instrument freon-22 is significant than that of SFC [151].…”

Supercritical Fluid Extraction of Sulphamethazine and its Metabolites from Meat Tissues

“…Quantitative (ppm) investigations involving supercritical fluids include the extraction of sulphonamides from animal tissues (1)(2)(3), whole milk (4), and an aqueous drug formulation (5). A number of studies have shown that the more polar sulphonamides were more difficult to extract and required more rigorous conditions, such as higher methanol modifier concentrations (3) in the bulk carbon dioxide extracting fluid or higher working pressures.…”

Capillary electrophoresis separation of sulphonamides and dihydrofolate reductase inhibitors

“…Alcoholmodified supercritical C 0 2 has been used to elute SFA from silica [4], ODS and cyan0 [5], amino [6] bonded and unspecified [7] packed columns with varying degrees of success. The best of these [7] has demonstrated the isocratic, isobaric and isothermal baseline resolution of six SFA.…”