Analysis of cytokins status in blood serum of cows with subclinical form of ketosis

Kibkalo, D. V.

doi:10.15407/animbiol19.03.050

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…Similar phenomena with the application of epidural bupivacaine, which reduces the inflammatory reaction intensity were described by Docenko (2011), who studied the IL-1 level in the postoperative period. After surgery, the IL-6 level increased in the control group of animals, which indicated tissue damage during this period, as IL-6 enhances protein synthesis in the "acute phase" of inflammation (Kibkalo, 2017). In the experimental group of dogs seven days after surgery only an increase in the IL-4 level was found.…”

Section: Discussionmentioning

confidence: 85%

Regional anesthesiological support for the implementation of surgical interventions in the abdomen of dogs

Sliusarenko

Ilnitskiy

Bilyi

et al. 2021

Regul. Mech. Biosyst.

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Widespread use of surgical interventions in the abdomen of dogs determines the relevance of the study. The research tested the influence of therapeutic epidural blockade with 0.2% bupivacaine after surgical interventions on the background of potentiated local anaesthesia on the body of clinically healthy dogs undergoing ovariohysterectomy. In the control group postoperative analgesia was performed with the nonsteroidal anti-inflammatory drug rimadyl on the background of potentiated thiopental anaesthesia. Wound healing rates were determined in 10 animals of both control and experimental groups; blood counts and the level of inflammatory response were indicated in 5 animals of each group. The dynamics of reparative processes and complete wound healing in dogs of the experimental group occurred earlier than in animals of the control group, which confirmed the fact that the use of bupivacaine had a beneficial effect on tissue regeneration. The results of morphological and biochemical parameters of blood in animals of the experimental group manifested only an increase of leukocytes by 1.58 times, fibrinogen by 2.02 times, while in dogs of the control group the level of erythrocytes, haemoglobin and hematocrit decreased, leukocytes increased by 1.74 times, platelets decreased by 2.87 times and fibrinogen increased by 1.72 times. Among the stress response markers in the control group there was a 1.94 times increase in glucose level after surgery. In the experimental group there was a decrease in the intensity of the inflammatory reaction in dogs, accompanied by an increase of anti-inflammatory interleukin 4 (IL-4) only on the seventh day – 1.86 times, while in the control group the level of anti-inflammatory interleukin 1 receptor antagonist (IL-1RA) after three days increased by 2.30 times, after seven days – by 2.48 times, and the level of proinflammatory interleukin 6 (IL-6) after surgery increased by 2.57 times. It will be promising to conduct further research on the influence of therapeutic blockades with bupivacaine in animals in cases of various surgical interventions and pathological conditions, which will lead to faster recovery of animals and alleviate pathological processes.

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Section: Discussionmentioning

confidence: 85%

Regional anesthesiological support for the implementation of surgical interventions in the abdomen of dogs

Sliusarenko

Ilnitskiy

Bilyi

et al. 2021

Regul. Mech. Biosyst.

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The Effect of Subclinical Ketosis on the Hematological Indicators of the Blood of Highly Productive Cows

Nikitin¹,

Shiryaev²,

Nikitkina³

2022

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Purpose: to study the effects of subclinical ketosis on the hematological indicators of the blood of highly productive milk cows in the postal period. The studied animals are selected according to the principle of conditional analogues and divided into 3 groups of 5 goals each. Depending on the concentration in the blood of 3-hydroxybutirate, animals were divided into 3 groups: 1st group-less than 0.8 mmol/l; Group 2-1.2-1.4 mmol/l; 3rd group-more than 1.4 mmol/l. The conditions of their detention and feeding were the same for all groups. The determination of the level of 3-hydroxybutirates took place 2 times: on the 5th and 15th day after the hotel. Taking blood was carried out from the tail vein in front of the morning feeding. The blood serum was obtained by centrifugation (3000 rpm) with subsequent freezing at -20 ° C. The following indicators were determined in the samples: red blood cells, hemoglobin, hematocrit, the total volume of red blood cells, the average hemoglobin content in red blood cells, the distribution of red blood cells in the blood, leukocytes, granulocytes, monocytes, lymphocytes, thrombocytes, the average volume of platelets. Reliable differences have been established in the case of indicators of the level of red blood cells, hemoglobin and hematocrit in comparison of the 1st and 2nd groups with the 3rd group. A reliable correlation between the level of 3-hydroxybutirates and some hematological indicators (on various days after the hotel) has been established.

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Analysis of cytokins status in blood serum of cows with subclinical form of ketosis

Cited by 2 publications

References 2 publications

Regional anesthesiological support for the implementation of surgical interventions in the abdomen of dogs

Regional anesthesiological support for the implementation of surgical interventions in the abdomen of dogs

The Effect of Subclinical Ketosis on the Hematological Indicators of the Blood of Highly Productive Cows

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