Analysis of common and characteristic actions of Panax ginseng and Panax notoginseng in wound healing based on network pharmacology and meta-analysis

Wang, Zhen; Xie, Xueheng; Wang, Mengchen; Ding, Meng; Gu, Shengliang; Xing, Xiaoyan; Sun, Xiaobo

doi:10.1016/j.jgr.2023.02.005

Cited by 3 publications

(2 citation statements)

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“…Network pharmacology-grounded in systems biology and the network analysis of biological systems-focuses on selecting specific signaling nodes for drug design to target multiple targets . Researchers have utilized network pharmacology to discover active compounds in drugs and traditional Chinese medicine (TCM), analyze drug combination laws and formula pairings, and elucidate the overall mechanisms of action. , This approach combines the roles of target and effector molecules and can accurately predict the therapeutic efficacy and mechanism of action of drugs . Therefore, this study aimed to examine the core targets, biological processes, and potential mechanisms of action of Digitalis in treating ATC using network pharmacology.…”

Section: Introductionmentioning

confidence: 99%

“… 14 Researchers have utilized network pharmacology to discover active compounds in drugs and traditional Chinese medicine (TCM), analyze drug combination laws and formula pairings, and elucidate the overall mechanisms of action. 15 , 16 This approach combines the roles of target and effector molecules and can accurately predict the therapeutic efficacy and mechanism of action of drugs. 17 Therefore, this study aimed to examine the core targets, biological processes, and potential mechanisms of action of Digitalis in treating ATC using network pharmacology.…”

Section: Introductionmentioning

confidence: 99%

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Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer

Zhu,

Liang,

Guo

et al. 2024

ACS Omega

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Anaplastic thyroid cancer (ATC) is one of the most lethal malignant tumors for which there is no effective treatment. There are an increasing number of studies on herbal medicine for treating malignant tumors, and the classic botanical medicine Digitalis and its active ingredients for treating heart failure and arrhythmias have been revealed to have significant antitumor efficacy against a wide range of malignant tumors. However, the main components of Digitalis and the molecular mechanisms of its anti-ATC effects have not been extensively studied. Here, we screened the main components and core targets of Digitalis and verified the relationship between the active components and targets through network pharmacology, molecular docking, and experimental validation. These experiments showed that the active ingredients of Digitalis inhibit ATC cell activity and lead to ATC cell death through the apoptotic pathway.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer

Zhu,

Liang,

Guo

et al. 2024

ACS Omega

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Mechanism of Wenyang Shengji Ointment in treating diabetic wounds based on network pharmacology and animal experiments

Ding,

Xie,

Feng

et al. 2024

Digital Chinese Medicine

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Minor protopanaxadiol type sapogenins from the alkali hydrolysate of stems-leaves of Panax notoginseng

Jing,

Wang,

Wang

et al. 2024

Natural Product Research

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Two new protopanaxadiol type sapogenins, (3β,12,12,, were isolated from the alkali hydrolysate of stems-leaves of Panax notoginseng, along with seven known analogues (3-9). Their structures were elucidated by spectroscopic analyses and single-crystal X-ray diffraction. Compound 2 and the known sapogenins 5-8 displayed weak to moderate inhibition of NO production in LPS-induced RAW264.7 macrophages with IC50 values from 44.5 to 143.6 μM, respectively.

show abstract

Analysis of common and characteristic actions of Panax ginseng and Panax notoginseng in wound healing based on network pharmacology and meta-analysis

Cited by 3 publications

References 98 publications

Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer

Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer

Mechanism of Wenyang Shengji Ointment in treating diabetic wounds based on network pharmacology and animal experiments

Minor protopanaxadiol type sapogenins from the alkali hydrolysate of stems-leaves of Panax notoginseng

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