Analysis of chronic low back pain with magnetic resonance imaging T2 mapping of lumbar intervertebral disc

Ogon, Izaya; Takebayashi, Toru; Takashima, Hiroyuki; Tanimoto, Katsumasa; Ida, Kazunori; Yoshimoto, Mitsunori; Fujiwara, Hiroyoshi; Kubo, Toshikazu; Yamashita, Toshihiko

doi:10.1007/s00776-014-0686-0

Cited by 43 publications

(64 citation statements)

References 32 publications

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“…We performed an analysis to determine whether there was a relationship between the MRI T2 value and scores on the lumbar visual analog scale (lumbar VAS) and the Japanese Orthopedic Association back pain evaluation questionnaire (JOABPEQ), using patients with chronic LBP as subjects. Our results showed a negative correlation between MRI T2 values for the posterior AF and the lumbar VAS and a positive correlation between these MRI T2 values and the JOABPEQ (pain‐related disorder) score . We also showed a correlation between posterior AF degeneration and neuropathic pain .…”

Section: Ivd and Advances In Diagnostic Imagingsupporting

confidence: 53%

Imaging diagnosis for intervertebral disc

Ogon

Takebayashi²,

Takashima

et al. 2019

JOR Spine

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Various functional magnetic resonance imaging (MRI) techniques have been investigated in recent years and are being used in clinical practice for the patients with low back pain (LBP). MRI is an important modality for diagnosing intervertebral disc (IVD) degeneration. In recent years, there have been several reported attempts to use MRI T2 mapping and MRI T1ρ mapping to quantify lumbar disc degeneration. MRI T2 mapping involves digitizing water content, proteoglycan content, and collagen sequence breakdown as relaxation times (T2 values) at each site. These digitized values are used to create a map, that is, then used to quantitatively evaluate the metabolite concentrations within IVD tissues. MRI T2 mapping utilizes the T2 relaxation time to quantify moisture content and the collagen sequence breakdown. MRI T1ρ mapping digitizes water molecule dispersion within the cartilaginous matrix to evaluate the degree of cartilaginous degeneration. Magnetic resonance spectroscopy is a less‐invasive diagnostic test that provides biochemical information. Adequate analysis of the IVD has not yet been performed, although there are indications of a relationship between the adipose content of the multifidus muscle in the low back and LBP. The ultra short TE technique has been recently used to investigate lumbar cartilaginous endplates. Unlike diagnosis based on contrast‐enhanced images of the IVD, which depends on the recurrence of pain that is determined subjectively, MRI‐based diagnosis is less‐invasive and based on objective imaging findings. It is therefore expected to play a key role in the diagnostic imaging of IVD conditions in the future.

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Section: Ivd and Advances In Diagnostic Imagingsupporting

confidence: 53%

Imaging diagnosis for intervertebral disc

Ogon

Takebayashi²,

Takashima

et al. 2019

JOR Spine

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“…For example if there was degeneration of the disk between the fourth and the fifth lumbar vertebra, both vertebrae received mobilization as there is evidence to suggest that chronic LBP may be stemming from degenerated disks. 41 One session of MT per week, even though uncommon in clinical practice, was chosen due to technical reasons and because there is evidence to suggest its efficacy in improving pain 32 and disability 37 in subjects with chronic LBP. Also, even a single treatment of spinal mobilization has been found to display positive outcome on LBP levels.…”

Section: Methodsmentioning

confidence: 99%

Spinal mobilization vs conventional physiotherapy in the management of chronic low back pain due to spinal disk degeneration: a randomized controlled trial

Krekoukias

Gelalis

Xenakis

et al. 2016

Journal of Manual & Manipulative Therapy

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“…Another study found lower T2 values in the posterior AF in herniated discs in comparison to normal discs [13]. Similarly, Ogon et al, using a similar ROI analysis by dividing the disc into five parts, observed lower T2 relaxation times of the posterior AF in patients with chronic lower back pain [19]. This could be explained by the observation that the anterior part of the posterior AF is heavily influenced by the state of the NP.…”

Section: Discussionmentioning

confidence: 83%

“…High T2 values in the posterior AF may indicate a structural weakness of the collagen structure and/or higher water content. The literature suggests that the T2 relaxation time of the posterior AF could be useful for the evaluation of present or imminent DH [13,19].…”

Section: Introductionmentioning

confidence: 99%

Does T2 mapping of the posterior annulus fibrosus indicate the presence of lumbar intervertebral disc herniation? A 3.0 Tesla magnetic resonance study

et al. 2016

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Purpose Indicating lumbar disc herniation via magnetic resonance imaging (MRI) T2 mapping in the posterior annulus fibrosus (AF). Methods Sagittal T2 maps of 313 lumbar discs of 64 patients with low back pain were acquired at 3.0 Tesla (3T). The discs were rated according to disc herniation and bulging. Region of interest (ROI) analysis was performed on median, sagittal T2 maps. T2 values of the AF, in the most posterior 10% (PAF-10) and 20% of the disc (PAF-20), were compared. Results A significant increase in the T2 values of discs with herniations affecting the imaged area, compared to bulging discs and discs with lateral herniation, was shown in the PAF-10, where no association to the NP was apparent. The PAF-20 exhibited a moderate correlation to the nucleus pulposus (NP). Conclusions High T2 values in the PAF-10 suggest the presence of disc herniation (DH). The results indicate that T2 values in the PAF-20 correspond more to changes in the NP.

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Analysis of chronic low back pain with magnetic resonance imaging T2 mapping of lumbar intervertebral disc

Cited by 43 publications

References 32 publications

Imaging diagnosis for intervertebral disc

Imaging diagnosis for intervertebral disc

Spinal mobilization vs conventional physiotherapy in the management of chronic low back pain due to spinal disk degeneration: a randomized controlled trial

Does T2 mapping of the posterior annulus fibrosus indicate the presence of lumbar intervertebral disc herniation? A 3.0 Tesla magnetic resonance study

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