Analysis of Bone Samples from Patients with Spondyloarthritides—Identifying Causes of New Bone Formation in Axial Spondyloarthritis

Appel, Heiner; Sieper, Joachim

doi:10.3899/jrheum.150046

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Bone Formation In Spa1

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2021

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Cited by 2 publications

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“…As Appel and Sieper stated 1 , we reported the lack of inflammatory lesions in our set of tissue samples 2 . Yet in contrast to their interpretation, our findings did not result from the study of patients in the advanced stage of what we have called "ankylosing tarsitis", but for reasons that were already mentioned in the paper.…”

Section: To the Editormentioning

confidence: 55%

Bone Proliferation in Ankylosing Tarsitis Might Involve Mechanical Stress, and Hormonal and Growth Factors

et al. 2015

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Section: To the Editormentioning

confidence: 55%

Bone Proliferation in Ankylosing Tarsitis Might Involve Mechanical Stress, and Hormonal and Growth Factors

et al. 2015

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“…Remarkably, there are two pathways of bone formation, endochondral and pseudomembranous ossification, and both can participate in the pathogenic bone formation of SpA patients (67,(143)(144)(145). Intense research has elucidated some pathways related to bone formation in SpA, such as the Wnt and bone morphogenetic protein (BMP) pathways (84,146,147).…”

Section: Bone Formation In Spamentioning

confidence: 99%

Inflammatory Foot Involvement in Spondyloarthritis: From Tarsitis to Ankylosing Tarsitis

et al. 2021

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Spondyloarthritis (SpA) is a group that includes a wide spectrum of clinically similar diseases manifested by oligoarticular arthritis and axial or peripheral ankylosis. Although axial SpA is predominant in Caucasians and adult-onset patients, juvenile-onset and Latin American patients are characterized by severe peripheral arthritis and particularly foot involvement. The peripheral involvement of SpA can vary from tarsal arthritis to the most severe form named ankylosing tarsitis (AT). Although the cause and etiopathogenesis of axSpA are often studied, the specific characteristics of pSpA are unknown. Several animal models of SpA develop initial tarsitis and foot ankylosis as the main signs, emphasizing the role of foot inflammation in the overall SpA spectrum. In this review, we attempt to highlight the clinical characteristics of foot involvement in SpA and update the knowledge regarding its pathogenesis, focusing on animal models and the role of mechanical forces in inflammation.

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Analysis of Bone Samples from Patients with Spondyloarthritides—Identifying Causes of New Bone Formation in Axial Spondyloarthritis

Cited by 2 publications

References 21 publications

Bone Proliferation in Ankylosing Tarsitis Might Involve Mechanical Stress, and Hormonal and Growth Factors

Bone Proliferation in Ankylosing Tarsitis Might Involve Mechanical Stress, and Hormonal and Growth Factors

Inflammatory Foot Involvement in Spondyloarthritis: From Tarsitis to Ankylosing Tarsitis

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