Analysis of basic drugs in biological samples using dynamic single-interface hollow fiber liquid-phase microextraction combined with fast electromembrane extraction

Rahimi, Atyeh; Nojavan, Saeed; Maghsoudi, Majid

doi:10.1016/j.microc.2020.105001

Cited by 26 publications

(6 citation statements)

References 40 publications

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“…Also, the extraction performance was disrupted at a higher time than 20 min due to the electrolysis reaction. 27 It was hypothesized that the extended extraction time during the EME process resulted in heat generation, which caused back pressure in the microchip channels. The 20–60 mmol L −1 range for H + was tested as the donor phase concentration.…”

Section: Resultsmentioning

confidence: 99%

“…PAs are basic and ionizable compounds that can be selectively extracted and analyzed using this technique. 26,27…”

Section: Resultsmentioning

confidence: 99%

“…PAs are basic and ionizable compounds that can be selectively extracted and analyzed using this technique. 26,27 Overall, all researchers try to apply an analytical method with robust features. These features include having a wide selection of analytes with any structure, a wide selection of matrices like food, air, water, etc., and compatibility with analytical instruments.…”

Section: Comparison Of the Developed Methods With Previous Analytical...mentioning

confidence: 99%

“…The principles of EME are based on the electrostatic attraction, diffusion, and solubility of target analytes in the acceptor phase. 27 This emerging method uses an electrical potential to drive the ionic compounds from the donor to a clean acceptor phase through a porous membrane impregnated with a supported organic solvent. 28 This method has great potential for sample clean-up and preconcentration.…”

Section: Introductionmentioning

confidence: 99%

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The selective extraction of dietary polyamines from chicken breast using the application of a lab-on-a-chip electromembrane and dispersive liquid–liquid microextraction followed by gas chromatography-mass spectrometry

Barzegar,

Nabizadeh,

Kamankesh

et al. 2024

Anal. Methods

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show abstract

Section: Resultsmentioning

confidence: 99%

“…PAs are basic and ionizable compounds that can be selectively extracted and analyzed using this technique. 26,27…”

Section: Resultsmentioning

confidence: 99%

Section: Comparison Of the Developed Methods With Previous Analytical...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The selective extraction of dietary polyamines from chicken breast using the application of a lab-on-a-chip electromembrane and dispersive liquid–liquid microextraction followed by gas chromatography-mass spectrometry

Barzegar,

Nabizadeh,

Kamankesh

et al. 2024

Anal. Methods

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show abstract

“…The versatility of HF-LPME and CE could broaden the potential use of the suggested configuration for various analytes and sample types. Furthermore, coupling with mass spectrometric or laser-induced fluorescence detectors could enhance the selectivity and sensitivity of the analytical method [102].…”

Section: Combination Of Microextraction Techniquesmentioning

confidence: 99%

Advancements in solvent microextraction: Recent developments and diverse applications in the modern era

Rani,

Nanda,

Narang

et al. 2024

Separation Science Plus

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Solvent microextraction (SME) is designed to selectively isolate desired analytes while minimizing the presence of interfering substances in the extracted sample. There are different approaches from which single‐drop microextraction (SDME) can be amalgamated with various analytical methods to enhance its functionalities and improve the analysis of extracted compounds like gas chromatography, and liquid chromatography amplify sensitivity, selectivity, and the capacity to detect trace amounts of analytes in complex matrices. The review focuses on the intricacies of solid‐phase microextraction and elucidates its operational principles. Additionally, it explores various types of SDMEs, detailing their respective benefits, drawbacks, and potential applications in the future. A typical explanation of the construction and working of hollow fiber‐liquid phase microextraction as well as its types has been discussed. The applications of SMEs in the medical and biomedical fields from food analysis to environmental analysis like analysis and purification of water, organic pollutants, drug analysis, and screening of new drugs have been discussed and also illustrated in tabular form. The pros and cons of both analytical techniques are given in a tabular manner as well a broad comparison between different types of advanced SME techniques provides a new direction for environmental monitoring, food safety, and refining of impurities from water samples. The review provides a comprehensive overview of the current progress, recent obstacles, and future possibilities of SMEs in an appropriate manner. Despite numerous promising advancements, the utilization of SMEs remains a challenging field.

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An efficient microchip electromembrane extraction online with high‐performance liquid chromatography for the measurement of nicotine in high consumption vegetables

Barzegar,

Kamankesh,

Mohammadi

2024

Phytochemical Analysis

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IntroductionNicotine, a highly addictive substance, is naturally produced in the Solanaceae family of plants, particularly tobacco. The presence of nicotine in plant foods has adverse effects on the lungs, kidneys, heart, and reproductive system.ObjectiveA novel three‐phase microchip flat electromembrane coupled with online high‐performance liquid chromatography (HPLC) was developed to analyze nicotine in tomato, mushroom, eggplant, bell pepper, and red pepper.MethodsThe microchip was connected to the HPLC in online mode. All effective variables were optimized to achieve the best extraction response. The use of electric potential and 2‐nitrophenyl octyl ether −5% di(2‐ethylhexyl) phosphate as a modified supported liquid membrane (SLM) increased the sensitivity and selectivity.ResultsThe optimal extraction voltage, extraction time, and ion balance were 40 V, 10 min and 0, respectively. The dynamic linear range was 0.5–1000 ng g−1. The obtained recovery, relative standard deviation, and enrichment factor were 98%, 7%, and 35, respectively. The limits of detection 0.4 ng g−1 and the limits of quantification were obtained 1.3 ng g−1. The highest (105.0 ng g−1) and lowest (3.4 ng g−1) concentrations of nicotine were obtained for eggplant and tomato, respectively.ConclusionSelective electromembrane extraction of nicotine from the donor phase to the acceptor phase was performed by optimizing the main variables influencing the method mechanism. The new channel design in this analytical system and online injection increased efficiency, stability, and repeatability. The results revealed that this method is capable for the efficient determination of trace amount of nicotine in edible vegetables.

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Analysis of basic drugs in biological samples using dynamic single-interface hollow fiber liquid-phase microextraction combined with fast electromembrane extraction

Cited by 26 publications

References 40 publications

The selective extraction of dietary polyamines from chicken breast using the application of a lab-on-a-chip electromembrane and dispersive liquid–liquid microextraction followed by gas chromatography-mass spectrometry

The selective extraction of dietary polyamines from chicken breast using the application of a lab-on-a-chip electromembrane and dispersive liquid–liquid microextraction followed by gas chromatography-mass spectrometry

Advancements in solvent microextraction: Recent developments and diverse applications in the modern era

An efficient microchip electromembrane extraction online with high‐performance liquid chromatography for the measurement of nicotine in high consumption vegetables

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