Analysis of association of potentially functional genetic variants within genes encoding miR-34b/c, miR-378 and miR-143/145 with prostate cancer in Serbian population

Kotarac, Nevena; Dobrijević, Zorana; Matijasević, S; Savić‐Pavićević, Dušanka; Brajušković, Goran

doi:10.17179/excli2019-1257

Cited by 9 publications

(8 citation statements)

References 37 publications

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“…These data further indicate that rs4705342 might be a functional genetic polymorphism. The C allele of rs4705342 has been reported as a risk factor for developing intracranial aneurysm and prostate cancer (14,22). However, a protective role was observed for the rs4705342 C variant against cancer risk in a meta-analysis (23).…”

Section: Discussionmentioning

confidence: 95%

A functional polymorphism of microRNA-143 is associated with the risk of type 2 diabetes mellitus in the northern Chinese Han population

Kong

Duan²,

Wang³

et al. 2022

Front. Endocrinol.

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ObjectiveTo explore the association between two polymorphisms of microRNA-143 (miR-143) and the risk of type 2 diabetes mellitus (T2DM) in the northern Chinese Han population.Study DesignThis case–control study involved 326 patients with T2DM and 342 healthy controls. Two genetic variants (rs4705342 and rs353292) of miR-143 were genotyped by the polymerase chain reaction/ligase detection reaction (PCR-LDR) method. The levels of miR-143 in the serum from 52 T2DM patients and 55 healthy subjects were investigated by quantitative real-time PCR (qRT–PCR).ResultsThe CC genotype frequency of rs4705342 was significantly higher in the T2DM patients than in the healthy controls (P = 0.012). After adjusting for sex, age, and body mass index, the rs4705342 CC genotype was also related to a significantly increased risk of T2DM compared with the TT genotype (adjusted OR: 1.87; 95% CI = 1.09-3.19; P = 0.022). Stratified analyses demonstrated that T2DM patients with the rs4705342 CC genotype had significantly higher levels of low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), and glycated haemoglobin (HbA1C) than those carrying the rs4705342 TT genotype. The qRT–PCR results showed that the expression levels of miR-143 were significantly higher in the serum of cases than in the serum of controls (P < 0.001). Furthermore, the levels of miR-143 were significantly higher in the serum of T2DM patients carrying the rs4705342 CC genotype than in those carrying the TC and TT genotypes of rs4705342 (P = 0.005 and 0.003, respectively).ConclusionThe CC genotype of rs4705342 might be a risk factor for developing T2DM by increasing the expression of miRNA-143 in the northern Chinese Han population.

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Section: Discussionmentioning

confidence: 95%

A functional polymorphism of microRNA-143 is associated with the risk of type 2 diabetes mellitus in the northern Chinese Han population

Kong

Duan²,

Wang³

et al. 2022

Front. Endocrinol.

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“…Nevertheless, the findings of molecular genetic studies focusing on microRNA-related genes, as well as of studies analyzing the biomarker properties of circulatory microRNA in PCa, remain inconclusive. Since our previous case–control studies on microRNA-related genetic variants and PCa provided promising results [ 12 , 13 , 14 , 15 , 16 ], we further expanded our research topic by analyzing the expression of selected candidate microRNAs in plasma and EVs extracted from whole plasma samples obtained from Serbian patients diagnosed with PCa.…”

Section: Discussionmentioning

confidence: 99%

MiR-375 and miR-21 as Potential Biomarkers of Prostate Cancer: Comparison of Matching Samples of Plasma and Exosomes

Joković

Dobrijević

Kotarac

et al. 2022

Genes

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MiR-21 and miR-375 have been reported as dysregulated in prostate cancer (PCa) in multiple previous studies. Still, variable or even opposing data for the expression of these microRNAs in PCa were found, and their potential biomarker properties remain elusive. In an attempt to clarify their significance as PCa biomarkers, as well as to compare different types of specimens as a source of relevant microRNAs, we used plasma and matching plasma-derived exosomes from patients with PCa and patients with benign prostatic hyperplasia (BPH). Plasma and exosomes were obtained from 34 patients with PCa and 34 patients with BPH, and their levels of expression of miR-21 and miR-375 were determined by RT-qPCR. We found no significant difference in the level of expression of these microRNAs in plasma and exosomes between patients with PCa and BPH. The level of exosomal miR-21 was elevated in PCa patients with high serum PSA values, as well as in patients with aggressive PCa, while for plasma samples, the results remained insignificant. For miR-375, we did not find an association with the values of standard prognostic parameters of PCa, nor with cancer aggressiveness. Therefore, our results support the potential prognostic role of exosomal miR-21 expression levels in PCa.

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“…Additional IGF-related targets of miR-143 include components of the RAS/RAF/MAPK pathway, highlighting the importance of tumor-suppressive activities of this microRNA in the molecular basis of CRC [ 153 , 165 , 166 ]. Various genetic variants within the miR-143/145 locus were found to be associated with CRC susceptibility, risk of developing other malignancies and cancer aggressiveness [ 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 ].…”

Section: Insulin-like Growth Factors and Colorectal Cancermentioning

confidence: 99%

The Insulin-like Growth Factor System and Colorectal Cancer

Gligorijević

Dobrijević

Šunderić

et al. 2022

Life

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Insulin-like growth factors (IGFs) are peptides which exert mitogenic, endocrine and cytokine activities. Together with their receptors, binding proteins and associated molecules, they participate in numerous pathophysiological processes, including cancer development. Colorectal cancer (CRC) is a disease with high incidence and mortality rates worldwide, whose etiology usually represents a combination of the environmental and genetic factors. IGFs are most often increased in CRC, enabling excessive autocrine/paracrine stimulation of the cell growth. Overexpression or increased activation/accessibility of IGF receptors is a coinciding step which transmits IGF-related signals. A number of molecules and biochemical mechanisms exert modulatory effects shaping the final outcome of the IGF-stimulated processes, frequently leading to neoplastic transformation in the case of irreparable disbalance. The IGF system and related molecules and pathways which participate in the development of CRC are the focus of this review.

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Analysis of association of potentially functional genetic variants within genes encoding miR-34b/c, miR-378 and miR-143/145 with prostate cancer in Serbian population

Cited by 9 publications

References 37 publications

A functional polymorphism of microRNA-143 is associated with the risk of type 2 diabetes mellitus in the northern Chinese Han population

A functional polymorphism of microRNA-143 is associated with the risk of type 2 diabetes mellitus in the northern Chinese Han population

MiR-375 and miR-21 as Potential Biomarkers of Prostate Cancer: Comparison of Matching Samples of Plasma and Exosomes

The Insulin-like Growth Factor System and Colorectal Cancer

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