1998
DOI: 10.1001/archderm.134.8.1006
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Analysis of Antibiotic Susceptibilities of Skin Wound Flora in Hospitalized Dermatology Patients

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Cited by 79 publications
(54 citation statements)
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References 14 publications
(9 reference statements)
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“…Historically, oxacillin has been a drug of choice for many gram-positive skin and soft tissue infections (27). However, the emergence of multidrugresistant gram-positive species, particularly MRSA, is an increasing concern; in recent surveys in the United States and Europe, methicillin resistance has been observed in 22 to 25% of S. aureus isolates from patients with skin and soft tissue infections (5,13). Although patients with MRSA were excluded from this study, the increasing prevalence of resistant gram-positive pathogens suggests that many patients will require treatment with an antimicrobial that has activity against these resistant strains.…”
Section: Discussionmentioning
confidence: 99%
“…Historically, oxacillin has been a drug of choice for many gram-positive skin and soft tissue infections (27). However, the emergence of multidrugresistant gram-positive species, particularly MRSA, is an increasing concern; in recent surveys in the United States and Europe, methicillin resistance has been observed in 22 to 25% of S. aureus isolates from patients with skin and soft tissue infections (5,13). Although patients with MRSA were excluded from this study, the increasing prevalence of resistant gram-positive pathogens suggests that many patients will require treatment with an antimicrobial that has activity against these resistant strains.…”
Section: Discussionmentioning
confidence: 99%
“…Despite these encouraging results, the development of high and rapidly increasing rates of ciprofloxacin resistance among isolates of methicillin-resistant S. aureus as well as P. aeruginosa has discouraged the role of fluoroquinolones in the empiric therapy of severe SSTIs (8,21,30). This has led to the development of newer fluoroquinolones such as levofloxacin, moxifloxacin, and trovafloxacin, with higher potencies against quinolone-resistant S. aureus, P. aeruginosa, and anaerobes (4,25).…”
Section: Discussionmentioning
confidence: 99%
“…; and anaerobes such as Bacteroides fragilis are frequently isolated (8,12,13,18,32 Frequently used antimicrobial agents have included expandedspectrum cephalosporins (e.g., cefoxitin, cefotetan, cefmetazole), imipenem-cilastatin, ␤-lactam-␤-lactamase inhibitor combinations (e.g., piperacillin-tazobactam, ticarcillin-clavulanate), and fluoroquinolones (13,14,15,18,20,35). However, emerging resistance, particularly among S. aureus, P. aeruginosa, and enterococci, is making the choice of treatment increasingly more difficult (23).…”
mentioning
confidence: 99%
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“…Colsky and colleagues (16,17) compared the antibiotic resistance profiles of isolates from patients with skin wounds and revealed a marked increase in the rate of oxacillin resistance among S. aureus isolates.…”
mentioning
confidence: 99%