ANALISIS HASIL PEMERIKSAAN KADAR LOW-DENSITY LIPOPROTEIN  (LDL-Chol) METODE DIREK DAN INDIREK

Djasang, Syahida

doi:10.32382/mak.v8i2.846

Cited by 4 publications

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“…Indirect method of measuring LDL cholesterol levels is carried out through several stages of examination, namely by examining Total Cholesterol, HDL Cholesterol, and Triglycerides first, then continuing with calculating using the Friedewald formula (LDL = Total Cholesterol -HDL Cholesterol -1/5 Triglycerides) to obtain the results of the LDL Cholesterol examination, whereas in the direct method of LDL Cholesterol examination the measurement is carried out directly using a photometer without involving other examinations which can influence LDL Cholesterol levels such as the indirect method (Djasang, 2017). The calculations used in the Friedewald formula cannot be applied to patients who are not fasting, because the presence of post-meal chylomicrons contains a lot of triglycerides, therefore patients must fast 10-12 hours before sampling to avoid high triglycerides (Ramalina Yani, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…The purpose of HDL is to move and dispose of cholesterol from blood vessels to the liver or other tissues so that it can be eliminated as bile acids (Maulina, 2017). The results of a lipid profile examination can confirm whether the patient has the potential or is at risk of developing diseases, such as cardiovascular disease, pancreatitis, and diabetes which occur due to increased cholesterol levels in the body (Djasang, 2017). LDL cholesterol often known as bad cholesterol is a lipoprotein particle that participates in the transport of fat fractions, mainly transporting cholesterol from the liver to peripheral cells, and is an atherogenic lipoprotein due to being one of the causes of the formation of atherosclerotic plaques.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of LDL Cholesterol Levels Using Friedewald Formula and Direct Method Homogeneous Assay

Yakobus,

Septiani,

Safari

2024

IJATSS

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LDL (Low-Density Lipoprotein ) is a lipoprotein that plays a role in transporting fat fractions, especially cholesterol from the liver to peripheral cells. LDL cholesterol examination can be done by 2 methods, namely indirect and direct methods. Measurement of LDL cholesterol levels by indirect method (Fredewald Formula Fredewald ) is done by involving other examinations, namely Total cholesterol, HDL cholesterol, and triglycerides, while the direct method ( homogeneous Assay ) has full automatic capability in determining LDL cholesterol directly. The purpose of the study was to determine whether there were differences in LDL cholesterol levels using Indirect and Direct methods. The research method used the type of analytical observational research. The study was conducted in the main Clinical Laboratory of Mekarsari using 30 samples with the Total Sampling technique. The test used is the Paired-Samples T Test. The average result of LDL cholesterol levels using the indirect method was 107.37 mg/dl and the direct method was 117.10 mg/dl. The test results of different Paired-samples T Test obtained sig.0.000 due to GIS.<0.05 it can be concluded that there is a significant difference between LDL cholesterol between the indirect method ( Friedewald formula ) and direct method (homogeneous Assay)

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation of LDL Cholesterol Levels Using Friedewald Formula and Direct Method Homogeneous Assay

Yakobus,

Septiani,

Safari

2024

IJATSS

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“…The resulting serum was immediately separated into an Eppendorf tube. The blood serums from the 6 groups, namely normal control, negative control, positive control, PST, PSS, and PSR which had been separated were put into the auto analyzer to measure total cholesterol, HDL, and triglyceride levels [26].…”

Section: Initial Total Cholesterol Hdl and Triglyceride Measurementsmentioning

confidence: 99%

The Cardioprotective Effect of Polysaccharide Sulphate Isolated from Brown Algae (Sargassum polycystum)

Marzaman,

Amir,

Ramadhan

et al. 2024

BIO Web Conf.

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The incidence of atherosclerosis is characterized by an increase in the value of low-density lipoprotein (LDL) and a decrease in the value of high-density lipoprotein (HDL) as well as an increase in the total white blood cell count which can indicate the occurrence of atherosclerosis. This study used 18 rats which were divided into 6 groups of 3 each, namely a normal control group, a negative control group (CMC 0.5%), a positive control group (Simvastatin 20 mg/kg BW), and 3 groups given a sulfate polysaccharide isolate compound test material (dosage of 250, 50, and 10 mg/kg of body weight). The results showed that sulfated polysaccharide isolates had an effect in reducing white blood cells significantly between doses of 250 mg/kg BW and 50 mg/kg BW as well as reducing SGOT levels. Unfortunately it did not reduce the SGPT level. The results of the Mann-Whitney post hoc test showed that administration of sulfated polysaccharides at an optimal dose of 250 mg/kg BW reduced the number of foam cells in the atherosclerotic white rats' (Rattus norvegicus) aortas that were given a high-fat diet and had activity in reducing CKMB levels compared to other doses.

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“…Low-density lipoprotein (LDL) apabila terlalu banyak dalam darah dapat menyebabkan akumulasi endapan lemak (plak) dalam arteri (proses aterosklerosis), sehingga aliran darah menyempit. Plak ini kadang-kadang bisa pecah dan menimbulkan masalah besar untuk jantung dan pembuluh darah (Djasang, 2019).…”

Section: Pendahuluanunclassified

Relationship between Waist Circumference (Abdomen) and Triglyceride and Low Density Lipoprotein-Cholesterol (LDL-C) Levels in Premenopausal Women

Abbas

Mus

2022

Medula

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Background: Premenopausal is a period that women will experience before heading to the menopause phase in the age range of 4 5-55 years. In the premenopausal period it is characterized by the instability of the hormone estrogen which will affect lipid metabolism which is closely related to the increase in abdominal fat known as abdominal or central obesity . The instability of the hormone estrogen results in hormonal changes that affect the levels of lipids in the body such as TG and LDL-Chol levels in the blood. Purpose(s): This study aims to determine whether there is a relationship between Waist Circumference (Abdomen) and Triglyceride and Low Density Lipoprotein-Cholesterol (LDL-C) Levels in Premenopausal Women. Methods: This study used an analytical correlative method with a cross-sectional study approach. This study involved 40 research subjects who met the criteria. Results: In the results of the pearson correlation test analysis to determine the relationship between the abdominal waist circle and TG levels in premenopausal women, the results of the p value = 0.351 and the pearson correlation test value = 0.15 were obtained. In the correlation test between waist circumference (abdomen) and LDL- Chol levels in premenopausal women, a value of p = 0.164 with a pearson correlation value of 0.224 was obtained. Conclusion: There is no relationship between Waist Circumference (Abdomen) and Triglyceride and Low Density Lipoprotein-Cholesterol (LDL-C) Levels in Premenopausal Women.Keywords: Premenopause, Waist Circumference, Lipid, Triglycerides, Low Density Lipoprotein

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ANALISIS HASIL PEMERIKSAAN KADAR LOW-DENSITY LIPOPROTEIN (LDL-Chol) METODE DIREK DAN INDIREK

Cited by 4 publications

References 0 publications

Correlation of LDL Cholesterol Levels Using Friedewald Formula and Direct Method Homogeneous Assay

Correlation of LDL Cholesterol Levels Using Friedewald Formula and Direct Method Homogeneous Assay

The Cardioprotective Effect of Polysaccharide Sulphate Isolated from Brown Algae (Sargassum polycystum)

Relationship between Waist Circumference (Abdomen) and Triglyceride and Low Density Lipoprotein-Cholesterol (LDL-C) Levels in Premenopausal Women

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