“…Bioactive compounds reported from several types of sea cucumbers include saponins, sterols, polyphenols, flavonoids, terpenoids, steroids, alkaloids, and lectins (Bordbar et al, 2011;Soltani et al, 2014). In addition, the results of research on the activity of bioactive compounds in sea cucumbers show their potential as antitumor (Holothuria mobile) (Shimada, 1969), antibacterial (Holothuria edulis, Holothuria leucospilota) (Sergey, et al, 2009;Arash et al, 2014;Manoppo et al, 2017) antifungal (H.atra) (Nimah et al, 2019) and antioxidant (H.atra, S. Horrens, Holothuria scarba and Stichopus hermanii) (Rasyid, 2012;Nobsathian et al, 2016;Akerina et al, 2019). The presence of phenolic compounds is closely related to antioxidant activity because phenolic compounds have many phenol groups that play an essential role in protecting oxidative stress and preventing free radical initiation reactions (Fitriansyah et al, 2017;Diniyah et al, 2020).…”