Análisis descriptivo y estadístico del tratamiento de estados epilépticos en un hospital de referencia

Hortigüela-Saeta, M Montesclaros; Conejo-Moreno, David; Gutiérrez-Moreno, Miriam; Gómez-Saiz, Luna

doi:10.33588/rn.6010.2014517

Cited by 3 publications

(3 citation statements)

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“…Concerning demographic features, previous studies reported a higher prevalence of SE in boys and preschool children, with median ages ranging from 1.9 to 4.5 years, similar to our results (median age, 2.5 years; IQR, 1.3 to 5.0) [1,5,[11][12][13].…”

Section: Discussionsupporting

confidence: 91%

“…The association between etiology and age was detailed by Shinnar et al [15], who documented significant differences in the distribution of causes between the first and second year of life, with a rapid decrease in the frequency of acute symptomatic cases and a higher proportion of cryptogenic and remote symptomatic cases in the older children. CSE, particularly the generalized subtype, was the most frequent semiological classification, which also agrees with many published works [1,5,12,16]. Nonetheless, recent studies have focused on NCSE, especially in the PICU.…”

Section: Discussionsupporting

confidence: 88%

“…In a Cochrane review, intravenous lorazepam and intravenous diazepam led to more rapid seizure cessation, but in the absence of intravenous access, buccal midazolam or rectal diazepam were considered acceptable first-line ASMs [17]. Although phenytoin was the most frequently selected second-line ASM, as in previously published studies [12], it was followed by propofol as the second most used. Although propofol is not usually selected as a second-line ASM because of its safety profile, it is very effective in seizure cessation, particularly in refractory cases, and it can be used in the emergency room, especially with support from the PICU team [8].…”

Section: Discussionmentioning

confidence: 92%

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Status Epilepticus in Children: Experience in a Portuguese Tertiary Hospital

Morais¹,

Silva²,

Mota³

et al. 2023

Ann Child Neurol

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Purpose: Status epilepticus (SE) is a life-threatening neurological emergency, frequently diagnosed in pediatric patients. We aimed to characterize our pediatric cases of SE in an 11-year period according to the 2015 International League Against Epilepsy report. Methods: Clinical electronic records were retrospectively reviewed. All pediatric SE cases admitted from January 2010 to December 2020 were included, excluding neonates. SE was considered refractory if it persisted despite the administration of two appropriate antiseizure medications at acceptable doses. Results: We included 102 episodes, 55 (53.9%) in boys. The median age was 2.5 years (interquartile range, 1.3 to 5.0). Most episodes were classified as SE with prominent motor features (92.2%), and the most frequent etiological classification was acute symptomatic cause (84.3%). A benzodiazepine was used as the first-line antiseizure medication in 99 (97%) cases, of which diazepam was preferred (93%). The preferred second-line medication was phenytoin (65.7%). Midazolam was the most frequently responsible for termination of SE when given in a continuous infusion (47%). Episodes of SE were classified as refractory in 81 (79.4%) cases. Episodes of >60 minutes were more frequent in patients diagnosed with epilepsy (P=0.036), focal motor SE (P<0.001), and non-convulsive SE (P=0.037). The in-hospital mortality rate was 2.9%. Conclusion: Most of our findings are in accord with the current literature. Epilepsy, non-convulsive SE, and focal motor SE were associated with prolonged duration (>60 minutes), which reinforces the significance of the underlying neurological disease and semiological standardization in pediatric SE.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Status Epilepticus in Children: Experience in a Portuguese Tertiary Hospital

Morais¹,

Silva²,

Mota³

et al. 2023

Ann Child Neurol

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Características clínicas, etiología, tratamiento y evolución de la epilepsia refractaria en la infancia

Moreno¹

Self Cite

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Application and Exploration of Big Data Mining in Clinical Medicine

Zhang

Guo

Han

et al. 2016

Chinese Medical Journal

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Objective:To review theories and technologies of big data mining and their application in clinical medicine.Data Sources:Literatures published in English or Chinese regarding theories and technologies of big data mining and the concrete applications of data mining technology in clinical medicine were obtained from PubMed and Chinese Hospital Knowledge Database from 1975 to 2015.Study Selection:Original articles regarding big data mining theory/technology and big data mining's application in the medical field were selected.Results:This review characterized the basic theories and technologies of big data mining including fuzzy theory, rough set theory, cloud theory, Dempster–Shafer theory, artificial neural network, genetic algorithm, inductive learning theory, Bayesian network, decision tree, pattern recognition, high-performance computing, and statistical analysis. The application of big data mining in clinical medicine was analyzed in the fields of disease risk assessment, clinical decision support, prediction of disease development, guidance of rational use of drugs, medical management, and evidence-based medicine.Conclusion:Big data mining has the potential to play an important role in clinical medicine.

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Análisis descriptivo y estadístico del tratamiento de estados epilépticos en un hospital de referencia

Cited by 3 publications

References 0 publications

Status Epilepticus in Children: Experience in a Portuguese Tertiary Hospital

Status Epilepticus in Children: Experience in a Portuguese Tertiary Hospital

Características clínicas, etiología, tratamiento y evolución de la epilepsia refractaria en la infancia

Application and Exploration of Big Data Mining in Clinical Medicine

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