Análisis de la dinámica de vaciamiento gástrico en relación con la composición cualitativa de la ingesta. Comparación entre sujetos con normopeso y obesos

Molina, Emma; González, Alexandra Jima; Palma, F. Partida; Macías, Julián; Curiel, A. García; Ortega-Álvaro, A.; Molinero, M. Gómez; Jiménez, L. Escobar

doi:10.1157/13088413

Cited by 2 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, food components such as fatty acids (FA), proteins, and carbohydrates influence gastrointestinal conditions and hormone release differently. In obese people, a protein-rich diet resulted in delayed gastric emptying, whereas a high carbohydrate meal accelerated gastric emptying [4]. In general, FA chain length and the ratio between saturated and unsaturated FA have a regulatory effect on gastric emptying, on appetite, and on hormone release [5], for example, the anorexigenic-acting cholecystokinin (CCK) [5] and the orexigenic hormone ghrelin [6].…”

Section: Introductionmentioning

confidence: 99%

The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment

Sauer

Mack

Kohler

et al. 2014

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Background. Fat affects gastric emptying (GE). 5-Hydroxythryptophan (5-HTP) is involved in central and peripheral satiety mechanisms. Influence of 5-HTP in addition to saturated or monounsaturated fatty acids (FA) on GE and hormone release was investigated. Subjects/Methods. 24 healthy individuals (12f : 12m, 22–29 years, BMI 19–25.7 kg/m²) were tested on 4 days with either 5-HTP + short-chain saturated FA (butter), placebo + butter, 5-HTP + monounsaturated FA (olive oil), or placebo + olive oil in double-blinded randomized order. Two hours after FA/5-HTP or placebo intake, a 13C octanoid acid test was conducted. Cortisol, serotonin, cholecystokinin (CCK), and ghrelin were measured, as were mood and GE. Results. GE was delayed with butter and was normal with olive (P < 0.05) but not affected by 5-HTP. 5-HTP supplementation did not affect serotonin levels. Food intake increased plasma CCK (F = 6.136; P < 0.05) irrespective of the FA. Ghrelin levels significantly decreased with oil/5-HTP (F = 9.166; P < 0.001). The diurnal cortisol profile was unaffected by FA or 5-HTP, as were ratings of mood, hunger, and stool urgency. Conclusion. Diverse FAs have different effects on GE and secretion of orexigenic and anorexigenic hormones. Supplementation of 5-HTP had no effect on plasma serotonin and central functions. Further studies are needed to explain the complex interplay.

show abstract