Análise neuropsicológica de distúrbios cognitivos em pacientes com fibromialgia, artrite reumatoide e lúpus eritematoso sistêmico

Abstract

Introduction: This study assesses the possible existence of cognitive disorder associated with chronic diseases [fi bromyalgia (FM), rheumatoid arthritis (RA) and lupus (SLE)], and the infl uence of the variables age, educational level and psychiatric symptoms on those disorders. Materials and methods: The patients were referred by the Rheumatology Outpatient Clinic of the Hospital Universitário de Brasília (HUB), with ages ranging from 30 to 80 years, and were divided into the following three groups: FM, 13 patients; RA, 13 patients; and SLE, 11 patients. Their performance in the neuropsychological tests of memory, language, executive functions and neuropsychiatric inventory was assessed considering their type of chronic disease, educational level and age. In addition, the cutoff points of cognitive normality of population samples were compared with the patients' performances. Results: The cognitive disorders were shown to be associated with the three diseases studied, but with signifi cant differences between them. Conclusion: The variables studied (low educational level and advanced age) were associated with various degrees of impairment in the different cognitive functions in the three pathological groups. However, FM and SLE groups showed signifi cantly higher means of the neuropsychiatric symptoms of anxiety, irritability and hallucinations than the RA group in the neuropsychiatric inventory.

Premature Immunosenescence Is Associated with Memory Dysfunction in Rheumatoid Arthritis

“…In agreement with previous studies, we reported a worse cognitive function in RA patients than that in healthy controls [1,2,3,4]. It has recently been shown that patients with RA had reduced performance in tests assessing the cognitive spheres of visual-constructional apraxia [1].…”

“…It has recently been shown that patients with RA had reduced performance in tests assessing the cognitive spheres of visual-constructional apraxia [1]. In addition, individuals with RA had cognitive impairments in domains associated with executive function, visual-spatial learning/memory and verbal learning/memory [2].…”

“…RA has been associated with the premature aging of the immune system and an increased prevalence of age-related comorbidities, including cognitive impairment [1,2,3,4]. The prevalence rates of cognitive dysfunction in RA range from 30 to 70% [5,6].…”

Measurement of psycho-emotional constructs and self-management in health of patients with Rheumatics diseases

“…It was verified the predominance of women in this sample and similar results to other studies. [2,3,[26][27][28] According to Mota et al, [9] RA preferentially affects women in a ratio of 3:1. In the same way, authors affirm that SLE also affects women, but young ones and in a ratio of 10:1.…”

“…Rheumatic diseases are chronic diseases that generate negative implications in the physical, psychological and social spheres in their patients. [1] Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are examples of rheumatic diseases (RD), [2,3] characterized by persistent inflammatory reactions, especially articular ones, accompanied by pain and fatigue and alteration of the body image. [3] Rheumatoid arthritis is a systemic and progressive inflammatory disease that affects individuals of productive age leading to the loss of labor capacity, an important limitation in functional capacity and quality of life, [4][5][6] due to its clinical manifestations, which may be both articular and extra-articular.…”