Análise morfométrica da fenda palpebral de pacientes com retração palpebral na fase aguda da orbitopatia distireoidiana submetidos à injeção palpebral de toxina botulínica tipo A

Costa, Pedro Jorge Cavalcante; Saraiva, Fábio Petersen; Pereira, Ivana Cardoso; Matayoshi, Suzana

doi:10.1590/s0004-27492008000400003

Cited by 3 publications

(9 citation statements)

References 15 publications

(29 reference statements)

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“…13,14,18,20,21 When injected via a transcutaneous approach, a similar eyelid lowering effect with good safety and efficacy has been reported. 8,11 The mean dose of BTA injected in our study was 13.97 AE 2.50 U (range, 10-20 U). The dose of BTA was decided by the authors depending on the previously published reports and the amount of eyelid retraction and lateral flare.…”

Section: Discussionmentioning

confidence: 83%

“…Nonsurgical treatment for correction of UER is temporary and includes injection of BTA or steroid in levator aponeurosis, or hyaluronic acid gel fillers. [6][7][8][9][10][11][12][13][14][15]17,18 It lowers the eyelid position and thereby improves symptoms of dryness and facial appearance. The procedure is usually considered in patients waiting for the attainment of eyelid stability or those not willing for surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Studies on the effect of injection BTA in thyroid-related UER have shown that the response in correction of eyelid retraction varies between 1.7 and 4.24 mm (Supplementary Table 1). [6][7][8][9][10][11][12][13][14][15]17,18 To understand the reason for the variable response, we studied the correlation between the LMC thickness on UBM and clinical response to injection BTA in patients with thyroid-related UER. We also compared the LMC thickness in thyroid-related UER with normal controls and clinical response to BTA.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5] Published literature shows an unpredictable response to botulinum toxin A (BTA) injection in patients with thyroid-related UER. [6][7][8][9][10][11][12][13][14][15] To understand the underlying reason, we studied the levator-Muller's muscle complex (LMC) thickness on UBM and correlated with the clinical response to BTA injection in patients with inactive-stage of thyroid-related UER. To the best of our knowledge, there are no similar studies in the literature.…”

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confidence: 99%

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Correlation of Levator‐Muller's Complex Thickness on Ultrasound Biomicroscopy to Botulinum Toxin A Injection in Thyroid‐Related Upper Eyelid Retraction

Kandasamy

Agrawal

Pushker

et al. 2022

J of Ultrasound Medicine

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Objectives-To study the thickness of levator palpebra superioris-Muller's muscle complex (LMC) on ultrasound biomicroscopy (UBM) and to correlate with the clinical response to botulinum toxin A (BTA) injection in patients with inactive-stage of thyroid-related upper eyelid retraction (UER). We also studied the correlation of clinical parameters, preinjection with postinjection values.Methods-This was a prospective, interventional study. Patients with thyroidrelated UER who underwent subconjunctival injection of BTA were recruited. Demographic data and clinical details were evaluated. UBM (50 MHz) was done to measure the thickness of LMC. Patient's satisfaction was graded at each followup. Follow-up was done at 1 week, 1 month, and 3 months' time intervals.Results-A total of 13 patients were recruited and 26 eyes were divided into two groups; group 1 included eyes with UER (n = 17), and group 2 included eyes without UER (n = 9). There was a statistically significant reduction in margin reflex distance 1 (MRD1) after BTA injection at 1-week, 1-month, and 3-months follow-up with maximum reduction at 1 month. The mean LMC thickness of 26 eyes was 0.96 mm which was found to be significantly more than normal controls. On comparison of mean LMC thickness with the amount of UER and reduction in MRD1, we did not find a significant difference.Conclusions-Patients with TED have significantly thicker LMC on UBM than controls. Further studies are needed with a larger sample size on the correlation of UBM features of levator aponeurosis with response to BTA injection.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Correlation of Levator‐Muller's Complex Thickness on Ultrasound Biomicroscopy to Botulinum Toxin A Injection in Thyroid‐Related Upper Eyelid Retraction

Kandasamy

Agrawal

Pushker

et al. 2022

J of Ultrasound Medicine

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“…Therefore, noninvasive standardized digital photographs allow reliable ocular documentation and clinical assessment in GO, with regard to orbital changes. The effective measurement of oculometric parameters could lead to an objective estimation of the effects of therapeutic interventions 11, 18…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Oculometric Variables in Graves’ Ophthalmopathy

Miot

Fernandes

Jorge

et al. 2009

Clinics

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OBJECTIVESTo estimate oculometric parameters of Graves’ ophthalmopathy in comparison to healthy eyes using digital photography and digital image analysis.INTRODUCTION Graves’ ophthalmopathy is the main cause of eye proptosis. Because these protrusions cause clinically perceived distortions in orbital architecture, digital photographs can be used to detect and quantify these changes.METHODSWe carried out a cross-sectional study comprising 12 healthy volunteers and 15 Graves’ ophthalmopathy patients with the purpose of evaluating the use of simple, non-invasive digital photography to estimate oculometric parameters of Graves’ ophthalmopathy and compare them with the parameters of unaffected eyes.Facial photographs of cases and controls were taken in a standardized manner. Oculometric parameters were compared between the groups and then correlated to proptometer measures.RESULTSAll estimated oculometric variables showed significant differences between the groups, in particular with regard to mediopupilar aperture, lateral height, distance from the iris edge to the lateral boundary of the palpebral fissure, and distance from the higher point of the iris to the lateral limit of the palpebral fissure. The product of medial aperture and horizontal palpebral fissure also revealed greater discrepancy between the groups. Proptometer measures showed significant linear correlation between the distance from the iris edge to the lateral boundary of the palpebral fissure and between the distance from the higher point of the iris to the lateral limit of palpebral fissure (p<0.05).CONCLUSIONSComparative analysis of oculometric parameters in Graves’ ophthalmopathy suggests that eye proptosis is related to an asymmetric increase in lateral oculometric measures. Standardized digital photographs can be used in clinical practice to objectively estimate oculometric parameters of Graves’ ophthalmopathy patients.

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Dystonien, Therapie mit Botulinum-Toxin und alternative therapeutische Ansätze in der Ophthalmologie

Nepp

Horwath‐Winter

Leydolt

2015

Spektrum Augenheilkd.

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Análise morfométrica da fenda palpebral de pacientes com retração palpebral na fase aguda da orbitopatia distireoidiana submetidos à injeção palpebral de toxina botulínica tipo A

Cited by 3 publications

References 15 publications

Correlation of Levator‐Muller's Complex Thickness on Ultrasound Biomicroscopy to Botulinum Toxin A Injection in Thyroid‐Related Upper Eyelid Retraction

Correlation of Levator‐Muller's Complex Thickness on Ultrasound Biomicroscopy to Botulinum Toxin A Injection in Thyroid‐Related Upper Eyelid Retraction

Comparative Evaluation of Oculometric Variables in Graves’ Ophthalmopathy

Dystonien, Therapie mit Botulinum-Toxin und alternative therapeutische Ansätze in der Ophthalmologie

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