Análise morfológica da placenta da paca (Agouti paca, Linnaeus, 1766: Estudo ao microscópio de luz e à microscopia eletrônica de transmissão

Bonatelli, Marina; Machado, Márcia Rita Fernandes; Cruz, Claudinei da; Miglino, María Angélica

doi:10.1590/s1413-95962001000500005

Cited by 7 publications

(6 citation statements)

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“…The subplacenta has been described in several species among the Hystricomorph rodents [ 1 , 14 , 15 , 24 , 25 , 36 – 40 ]. In these species, the development of subplacenta is marked by an increase in the thickness of the cytotrophoblast lamellae forming the floor of the central excavation.…”

Section: Discussionmentioning

confidence: 99%

“…Some species within the Hystricomorph and Lagomorph sub-orders of the Rodentia have a specialized structure within their placentas, called a subplacenta [ 14 – 18 ], that is unusual among mammals. The structure is represented by zone of chorionic ectoderm, which is located in the central excavation of the placenta and is limited to the area of decidualization [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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The comparative aspects of hystricomorph subplacenta: potential endocrine organ

Miglino¹,

Matias²,

Rigoglio³

et al. 2021

BMC Zool

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Background The placenta of hystricomorph rodents, lagomorphs and some primates includes an unusual structure, termed a subplacenta, which essentially consists of trophoblastic cells located deep to the central implantation site within the area of decidualization. It has been suggested that the subplacenta is functionally important, although considerable controversy remains on the issue. In this context, our objective was to compare the architecture and structure of the subplacentas of different hystricomorph species, to investigate the possibility that it is active in hormone synthesis. Methods In total, the placentas of 3 capybaras (Hydrochaeris hydrochaeris), 2 pacas (Agouti paca), 5 agoutis (Dasyprocta leporina), 5 rock cavies (Kerodon rupestris) and 3 guinea pigs (Cavia porcellus) at different stages of pregnancy (early, middle and near term) were used for gross and microscopic examination. This included the preparation of latex injection casts, immunohistochemistry for steroidogenic enzymes, scanning and transmission electron microscopy. Tissue steroid concentrations were also determined. Results The gross morphology and microvascular arrangement of the subplacentas were similar among the hystricomorphs studied including ultra-structural verification of cytotrophoblast and syncytiotrophoblast in all species. In guinea pigs, trophoblast cells exhibited characteristics consistent with intense metabolic and secretory activity in general. However, immuno-histochemical evidence also indicated that subplacental trophoblast expressed key steroidogenic enzymes, mainly in the chorionic villus region, consistent with tissue steroid concentrations. Conclusions The subplacentas within placentas of hystricomorph rodent species are structurally similar and, in guinea pigs, have potential for steroid hormone secretion from, at least the early stages of pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The comparative aspects of hystricomorph subplacenta: potential endocrine organ

Miglino¹,

Matias²,

Rigoglio³

et al. 2021

BMC Zool

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“…A subplacenta é uma estrutura da placenta dos roedores da sub-ordem histricomorfos e, na paca, foi originalmente descrita por Bonatelli et al (2001Bonatelli et al ( ,2005. A placenta da paca (Agouti paca) tem um formato cuneiforme e integra-se à parede uterina, formando uma protuberância discóide na face voltada para o feto, e o ápice inserido na parede uterina.…”

Section: Discussão 6 Discussãounclassified

A subplacenta da paca (Agouti paca, Linnaeus 1766)

Bonatelli¹

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“…Caviomorpha (guinea pig‐like rodents) is an example of haemomonochorial placentation (Mess, ; see Figure c). Investigated are not only the guinea pig Cavia porcellus and other small‐sized species such as degu ( Octodon degus ) or spiny rat ( Thrichomys laurentius ), but also larger ones such as the capybara ( Hydrochaeris hydrochaeris ), viscacha ( Lagostomus maximus ) and paca ( Agouti paca ) (Bonatelli, Machado, Cruz, & Miglino, ; Bonatelli et al, ; Duval, ; Flamini et al, ; Kanashiro, Santos, Miglino, Mess, & Carter, ; Kaufmann & Davidoff, ; Mess, ,b; Miglino et al, ; Oliveira et al, ; Oliveira, Carter, Bonatelli, & Miglino, ; Oliveira, Favaron, Ambrosio, Miglino, & Mess, ). They are characterized by a complex of derived, very stable conditions of placentation, for example invasive implantation and a fully inverted yolk sac placenta.…”

Section: Haemochorial Placentamentioning

confidence: 99%

Extracellular matrix in epitheliochorial, endotheliochorial and haemochorial placentation and its potential application for regenerative medicine

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Mess

Orechio

et al. 2016

Reprod Domestic Animals

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A placenta is defined as structural approximation of maternal and foetal tissues to perform physiological exchange. Associated processes of differentiation and the establishment of its cells take place within the extracellular matrix (ECM) that provides a rich environment of collagens, fibronectins, cytokines and other components. Placental ECM is promising for tissue regeneration purposes, because it has immune tolerance capacities that may cause only minimal rejections of transplants with immunological differences between donor and recipient. However, specific characteristics of ECM during evolution of the structurally very diverse mammalian placenta are not yet revealed. We here address the major aspects of placental types, that is non-invasive (epitheliochorial), medium (endotheliochorial)-to-high (haemochorial) invasive nature of the interhemal barrier between the foetal and maternal blood system as well as their main components of ECM with special reference to species that are commonly used as animal models for human placentation and in the potential applications for regenerative medicine.

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Análise morfológica da placenta da paca (Agouti paca, Linnaeus, 1766: Estudo ao microscópio de luz e à microscopia eletrônica de transmissão

Cited by 7 publications

References 0 publications

The comparative aspects of hystricomorph subplacenta: potential endocrine organ

The comparative aspects of hystricomorph subplacenta: potential endocrine organ

A subplacenta da paca (Agouti paca, Linnaeus 1766)

Extracellular matrix in epitheliochorial, endotheliochorial and haemochorial placentation and its potential application for regenerative medicine

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