Análise do perfil lipídico de pacientes submetidos à gastrectomia vertical e à derivação gástrica em Y de Roux.

Abstract

Objective: to compare the improvements in lipid profile in patients undergoing sleeve gastrectomy (SG) and Rouxen-Y gastric bypass (RYGB). Methods: in a mixed cohort study, we evaluated 334 patients undergoing SG and 178 patients undergoing RYGB at the University Hospital of the Federal University of Pernambuco and at the Real Hospital Português de Beneficência, Recife, PE, Brazil. We measured serum levels of total cholesterol, LDL, HDL and triglycerides preoperatively and at three, six, 12 and 24 months follow-up. Results: the SG group consisted of 58 men and 276 women. In the group submitted to RYGB, there were 64 men and 114 women. The mean age was 37.2±20.5 years in the SG group and 41.9±11.1 years in the RYGB group. The preoperative mean BMI was 39.4±2.6kg/m 2 and 42.7±5.8kg/m 2 for the SG and RYGB groups, respectively. In the preoperative period, 80% of the patients had at least one abnormality in the lipid profile. Two years after surgery, there was improvement in total cholesterol, LDL, HDL and triglycerides in the group submitted to RYGB. In the group submitted to SG, after two years there was improvement in total cholesterol, HDL and triglyceride levels. Conclusion: both techniques resulted in improvements in the lipid profile, but the RYGB was more effective. LiraAnalysis of the lipid profile of patients submitted to sleeve gastrectomy and Roux-en-Y gastric bypass. 2 Rev Col Bras Cir 45(6):e1967 Lira Analysis of the lipid profile of patients submitted to sleeve gastrectomy and Roux-en-Y gastric bypass. 4 Rev Col Bras Cir 45(6):e1967

Metabolomic Profiling of Lipids and Fatty Acids: 3 Years Postoperative Laparoscopic Sleeve Gastrectomy

“…Further, the lipid profile was apparently more beneficial among patients 3 years after undergoing LSG than among adults with obesity with matched age and BMI. Considering that patients in previous studies had lower triglyceride levels and higher HDL-C levels up to 2 years postoperatively [6,7], LSG could have an even longer positive impact on some of the lipid profile parameters, especially HDL-C, up to 3 years after the procedure. This effect might be explained by the improvement of HDL-C efflux capacity [27].…”

“…Moreover, the control group participants were not on any medication. However, in the patient groups the medication details are as: B12, eight (8); neurobion, two (2); vitamin D, twenty-one (21); multivitamins, five (5); a combination of calcium and vitamin D, five (5); proton pump inhibitors, seven (7); iron, nine (9); metformin, one (1) and zinc, one (1). None of the patients were taking aspirin or thiamine supplements.…”

“…Apart from weight reduction, LSG can induce dietary and metabolic changes that can improve obesity-related comorbidities, including diabetes and hypertension, and ultimately, reduce patient's cardiometabolic risk [5]. Consistently, the total cholesterol (TC) and triglyceride levels generally decrease, and the high-density lipoprotein (HDL) level increases up to 2 years after surgery [6,7]. LSG also likely alters other blood nutritional markers, such as fatty acid (FA) levels.…”

“…Patients with an effective and sustainable weight loss option experience weight regain of up to 15% of their original weight within 2-10 years postoperatively [4]. Noticeably, there is a lack of evidence regarding the beneficial impacts of LSG on lipid and FA profiles, activity of enzymes involved in endogenous FA synthesis, and the global cardiometabolic risk, as suggested by available studies focusing on LSG [7,8]. In addition, none of these studies was conducted over a period of 2 postoperative years.…”

Effect of sleeve gastrectomy on lipid parameters and cardiometabolic risk in young women

“…Studies have shown that sleeve gastrectomy has influence in the reduction of low density lipoproteins (LDL-c), total cholesterol (TC ), triglycerides (TG), and in the increase in high density lipoprotein (HDL-c) [11][12][13] . These…”