Análise comparativa da cicatrização da pele com o uso intraperitoneal de extrato aquoso de Orbignya phalerata (babaçu). Estudo controlado em ratos

Martins, Nelson Lúcio Parada; Malafaia, Osvaldo; Ribas-Filho, Jurandir Marcondes; Heibel, Marcel; Baldez, Raimundo Nonato; Vasconcelos, Paulo Roberto Leitão de; Moreira, Hamílton; Mazza, Marcelo; Nassif, Paulo Afonso Nunes; Wallbach, Tatiana Zacharow

doi:10.1590/s0102-86502006000900010

Cited by 36 publications

(35 citation statements)

References 8 publications

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“…We subdivided each of these groups into three cages, each with four animals, according to the time they would be submitted to euthanasia, seven, 14 and 21 days 16 .…”

Section: Methodsmentioning

confidence: 99%

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process

Martini

Scapini

Collaço

et al. 2016

Rev. Col. Bras. Cir.

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Objectives: to evaluate, histologically and macroscopically, the influence of Copaifera multijuga (Copaíba) oil-resin on the healing process of cutaneous wounds, comparing it with nitrofurazone. Methods: we divided 36 rats into three groups of 12 animals, according to the treatment to be administered. Group SL (control) received saline on the lesion; the Group OIL received topical treatment with Copaíba oil; and the Group NITRO was treated with Nitrofurazone. We inflicted a circular wound of 8mm in diameter on the back of each animal. We subdivided each of the three groups of 12 animals into three subgroups, according to treatment time and euthanasia (7, 14 and 21 days). All animals received the proposed treatment daily. We photographed the lesions for area measurement, as well as for evaluation of macroscopic aspects. We resected and stained the scars to quantify and qualify elastic fibers, collagen, degree of epithelization, neovascularization and inflammation. Results: although the saline solution provided a faster wound closure in its initial phase, after 14 days the wound size of the three groups tested was the same. Levels of inflammation and neovascularization were similar in all three groups. The amount of collagen and elastic fibers was higher in the Nitrofurazone and Copaíba oil groups. Conclusion: in male Wistar rats, Copaifera multijuga oil-resin positively influences the healing process, but it is less effective than nitrofurazone in healing by secondary intention.

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“…We subdivided each of these groups into three cages, each with four animals, according to the time they would be submitted to euthanasia, seven, 14 and 21 days 16 .…”

Section: Methodsmentioning

confidence: 99%

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process

Martini

Scapini

Collaço

et al. 2016

Rev. Col. Bras. Cir.

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“…Histology revealed a delay in the skin wound healing of the mice that received hydrocortisone. On the seventh postoperative day, the Control Group was already in the fibroplasia phase, with intense fibroblasts cells and deposition of collagen fibers, while the groups receiving corticosteroid were still in the inflammatory phase, with scarce fibroblast cells and thin disarrayed collagen fibers 13 . After the second postoperative week, the healing process of all animals was better organized, with no differences among the groups, displaying well-formed connective tissue rich in ordered collagen fibers.…”

Section: Upon Histological Assessment It Was Verified Thatmentioning

confidence: 99%

“…Only adult males were used to avoid the hormonal influence of the estrus cycle of females, which could interfere in the process of skin wound healing 13 .…”

Section: Upon Histological Assessment It Was Verified Thatmentioning

confidence: 99%

“…Following other authors 7,13 , the administration of the drug was initiated in the preoperative phase and continued until the day the animals were killed. According to literature 7,8 , when corticosteroids are administered before surgery and maintained postoperatively, their harmful effects are more evident.…”

Section: Upon Histological Assessment It Was Verified Thatmentioning

confidence: 99%

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Influence of local or systemic corticosteroids on skin wound healing resistance

Alberti¹,

Vasconcellos

Petroianu³

2012

Acta Cir. Bras.

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PURPOSE:To compare the resistance of skin wound healing of mice submitted to local or systemic hydrocortisone administration, in different postoperative periods. METHODS:An incision and suture was performed on the thoracic skin of 130 male mice: Group 1 (n = 10) resistance of the integer skin; Group 2 (n = 30) submitted only to skin incision and suture; Group 3 (n = 30) skin incision and suture followed by administration of saline fluid; Group 4 (n = 30) skin incision and suture followed by administration of local hydrocortisone; Group 5 (n = 30) skin incision and suture followed by administration of systemic hydrocortisone. The resistance of the wound healing and the weight of the animals were studied on the seventh, 14 th and 21 st postoperative days. Histological examination was also performed. RESULTS:The mice that received corticoid (groups 4 and 5) presented significant decreasing on their weight (p = 0.02). The Groups 3, 4 and 5 showed lower scar resistance than Group 2 on the seventh postoperative day (p < 0.05). On the 14 th and 21 st days, there was no difference on the skin would healing resistance (p > 0.05). CONCLUSION:Administration of hydrocortisone in mice is responsible for weight decreasing and reduction of the skin wound healing resistance during the first postoperative week. MÉTODOS:Foram estudados 130 camundongos machos submetidos à incisão e sutura de pele da região dorsal do tórax: Grupo 1 (n = 10) resistência da pele íntegra; Grupo 2 (n = 30) incisão da pele e sutura, sem administração de corticóide; Grupo 3 (n = 30) incisão da pele e sutura, seguidas de injeção local de solução salina; Grupo 4 (n = 30) incisão da pele e sutura, seguidas de injeção local de hidrocortisona e Grupo 5 (n = 30) incisão da pele e sutura, seguidas de injeção intraperitoneal de hidrocortisona. Foram avaliadas a resistência cicatricial da pele e a variação ponderal no sétimo, 14º e 21º dias pós-operatórios, bem como sua histologia. RESULTADOS:Os camundongos que receberam hidrocortisona tiveram decréscimo ponderal (p = 0,02). Quanto à resistência cicatricial da pele, os Grupos 3, 4 e 5 apresentaram valor inferior ao Grupo 2, no sétimo dia pós-operatório (p = 0,031). No 14º e 21º dias, não houve diferença entre as tensões cicatriciais.CONCLUSÃO: A administração de hidrocortisona provoca redução ponderal em camundongos e a resistência cicatricial cutânea é menor na primeira semana pós-operatória.

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“…When administered intraperitoneally at a dose of 50 mg/kg of bodyweight, full coaptation of the edges of gastric wounds 13,14 and enhanced healing in the abdominal alba line were observed 15 .…”

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confidence: 99%

The effects of aqueous extract of babassu (Orbignya phalerata) on the pleura and lung parenchyma in rats

Amorim

Saad²,

Filho³

et al. 2016

Acta Cir. Bras.

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Análise comparativa da cicatrização da pele com o uso intraperitoneal de extrato aquoso de Orbignya phalerata (babaçu). Estudo controlado em ratos

Cited by 36 publications

References 8 publications

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process

Influence of local or systemic corticosteroids on skin wound healing resistance

The effects of aqueous extract of babassu (Orbignya phalerata) on the pleura and lung parenchyma in rats

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